Jawaharlal Nehru Technological University Hyderabad 2009 B.Pharm Medicinal chemistry-ii - Question Paper
Code No: R7501 Set No. 1
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
III B.Pharmacy. II Sem., I Mid-Term Examinations, March - 2010
MEDICINAL CHEMISTRY-I Objective Exam Name:_Hall Ticket No.
|
A |
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I Choose the correct alternative:
EDTA is an example for
1)
2)
3)
a) chelating agent b) sequestering agent c) both d) none Enzymes involved in conjugation reactions are
a) hydrolases b) amidases c) transferases d) reductases
Sulfonamide is an example for a) competitive enzyme inhibitor
b) non competitive enzyme inhibitor d) irreversible enzyme inhibitor
c) antimetabolite
4) Chlorpromazine belongs to the class of
b) butyrophenones
d) di phenyl amine derivatives
a) phenothiazines
c) thioxanthenes
Seretonin is an a) excitatory neurotransmitter
5)
6)
7)
8)
9)
10)
b) inhibitory neurotransmitter d) none
c) enzyme
Cyt P450 enzyme is helpful for the catalysis of a) oxidation reactions b) reduction reactions
c) hydrolysis reactions d) conjugation reactions
An amide local anaesthetic is
a) cocaine b) lignocaine c) benzocaine d) cinchocaine
Phenytoin is the derivative of a) barbituric acid b) oxazole
c) hydantoin d) triazole
Water - n-octanol system is used to measure
a) solubility b) lipophilicity c) partition coefficient d) surface activity
The starting compound for the synthesis of Diazepam
a) 2-amino 5-chloro benzophenone b) 2-nitro 5-chloro benzophenone
c) 2-chloro 5-amino benzophenone d) 2-chloro 5-nitro benzophenone
11) The inactive drug that can be converted to active drug on metabolism is
12) Water soluble chelating agent is known as-------------------.
13) Disulfiram is an irreversible inhibitor of-----------------------enzyme.
14) The IUPAC name of Procaine is-------------------------.
15) The IUPAC name of Trimethadione is----------------------
16) The barbiturate that acts as general anesthetic is-------------------------.
17) The halogen atoms present in halothane structure are--------------------.
18) Local anesthetic drugs act by blocking--------------------------------.
19) Glutethamide is------------------------drug.
20) Example for the hydrazine derivative of tricyclic antidepressant is-------
Code No: R7501 Set No. 2
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
III B.Pharmacy. II Sem., I Mid-Term Examinations, March - 2010
MEDICINAL CHEMISTRY-I Objective Exam Name: Hall Ticket No
|
A |
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
Choose the correct alternative:
I
1) Chlorpromazine belongs to the class of
a) phenothiazines b) butyrophenones
c) thioxanthenes d) di phenyl amine derivatives
2) Seretonin is an
a) excitatory neurotransmitter b) inhibitory neurotransmitter
c) enzyme d) none
3) Cyt P450 enzyme is helpful for the catalysis of
a) oxidation reactions b) reduction reactions
c) hydrolysis reactions d) conjugation reactions
4) An amide local anaesthetic is
a) cocaine b) lignocaine c) benzocaine d) cinchocaine
5) Phenytoin is the derivative of
a) barbituric acid b) oxazole c) hydantoin d) triazole
6) Water - n-octanol system is used to measure
a) solubility b) lipophilicity c) partition coefficient d) surface activity
7) The starting compound for the synthesis of Diazepam
a) 2-amino 5-chloro benzophenone b) 2-nitro 5-chloro benzophenone
c) 2-chloro 5-amino benzophenone d) 2-chloro 5-nitro benzophenone
8) EDTA is an example for
a) chelating agent b) sequestering agent c) both d) none
9) Enzymes involved in conjugation reactions are
a) hydrolases b) amidases c) transferases d) reductases
10) Sulfonamide is an example for
a) competitive enzyme inhibitor b) non competitive enzyme inhibitor
c) antimetabolite d) irreversible enzyme inhibitor
11) The IUPAC name of Procaine is-------------------------.
12) The IUPAC name of Trimethadione is----------------------
13) The barbiturate that acts as general anesthetic is-------------------------.
14) The halogen atoms present in halothane structure are--------------------.
15) Local anesthetic drugs act by blocking--------------------------------.
16) Glutethamide is------------------------drug.
17) Example for the hydrazine derivative of tricyclic antidepressant is-------
18) The inactive drug that can be converted to active drug on metabolism is
19) Water soluble chelating agent is known as-------------------.
20) Disulfiram is an irreversible inhibitor of-----------------------enzyme.
Code No: R7501 Set No. 3
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
III B.Pharmacy. II Sem., I Mid-Term Examinations, March - 2010
MEDICINAL CHEMISTRY-I Objective Exam Name: Hall Ticket No
|
A |
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I Choose the correct alternative:
1) Cyt P450 enzyme is helpful for the catalysis of
a) oxidation reactions b) reduction reactions
c) hydrolysis reactions d) conjugation reactions
2) An amide local anaesthetic is
a) cocaine b) lignocaine c) benzocaine d) cinchocaine
3) Phenytoin is the derivative of
a) barbituric acid b) oxazole c) hydantoin d) triazole
4) Water - n-octanol system is used to measure
a) solubility b) lipophilicity c) partition coefficient d) surface activity
5) The starting compound for the synthesis of Diazepam
a) 2-amino 5-chloro benzophenone b) 2-nitro 5-chloro benzophenone
c) 2-chloro 5-amino benzophenone d) 2-chloro 5-nitro benzophenone
6) EDTA is an example for
a) chelating agent b) sequestering agent c) both d) none
7) Enzymes involved in conjugation reactions are
a) hydrolases b) amidases c) transferases d) reductases
8) Sulfonamide is an example for
a) competitive enzyme inhibitor b) non competitive enzyme inhibitor
c) antimetabolite d) irreversible enzyme inhibitor
9) Chlorpromazine belongs to the class of
a) phenothiazines b) butyrophenones
c) thioxanthenes d) di phenyl amine derivatives
10) Seretonin is an
a) excitatory neurotransmitter b) inhibitory neurotransmitter
c) enzyme d) none
11) The barbiturate that acts as general anesthetic is-------------------------.
12) The halogen atoms present in halothane structure are--------------------.
13) Local anesthetic drugs act by blocking--------------------------------.
14) Glutethamide is------------------------drug.
15) Example for the hydrazine derivative of tricyclic antidepressant is-------
16) The inactive drug that can be converted to active drug on metabolism is
17) Water soluble chelating agent is known as-------------------.
18) Disulfiram is an irreversible inhibitor of-----------------------enzyme.
19) The IUPAC name of Procaine is-------------------------.
20) The IUPAC name of Trimethadione is----------------------
Code No: R7501 Set No. 4
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
III B.Pharmacy. II Sem., I Mid-Term Examinations, March - 2010
MEDICINAL CHEMISTRY-I Objective Exam Name: Hall Ticket No
|
A |
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I Choose the correct alternative:
Phenytoin is the derivative of
1)
2)
3)
4)
5)
6)
a) barbituric acid b) oxazole c) hydantoin d) triazole Water - n-octanol system is used to measure
a) solubility b) lipophilicity c) partition coefficient d) surface activity
The starting compound for the synthesis of Diazepam
a) 2-amino 5-chloro benzophenone b) 2-nitro 5-chloro benzophenone
c) 2-chloro 5-amino benzophenone d) 2-chloro 5-nitro benzophenone
EDTA is an example for
a) chelating agent b) sequestering agent c) both d) none Enzymes involved in conjugation reactions are
a) hydrolases b) amidases c) transferases d) reductases
Sulfonamide is an example for
b) non competitive enzyme inhibitor d) irreversible enzyme inhibitor
a) competitive enzyme inhibitor
c) antimetabolite
7) Chlorpromazine belongs to the class of
b) butyrophenones
a) phenothiazines c) thioxanthenes
d) di phenyl amine derivatives
Seretonin is an
8)
9)
a) excitatory neurotransmitter b) inhibitory neurotransmitter
c) enzyme d) none
Cyt P450 enzyme is helpful for the catalysis of a) oxidation reactions b) reduction reactions
c) hydrolysis reactions d) conjugation reactions
An amide local anaesthetic is
a) cocaine b) lignocaine c) benzocaine d) cinchocaine
11) Local anesthetic drugs act by blocking--------------------------------.
12) Glutethamide is------------------------drug.
13) Example for the hydrazine derivative of tricyclic antidepressant is-------
14) The inactive drug that can be converted to active drug on metabolism is
15) Water soluble chelating agent is known as-------------------.
16) Disulfiram is an irreversible inhibitor of-----------------------enzyme.
17) The IUPAC name of Procaine is-------------------------.
18) The IUPAC name of Trimethadione is----------------------
19) The barbiturate that acts as general anesthetic is-------------------------.
20) The halogen atoms present in halothane structure are--------------------.
-oOo-
Code No: BP415 Set No. 1
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name: Hall Ticket No
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
2. Halothane contains the halogenatom as
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
3. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
4. Conjugation reactions are
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
5. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
6. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
7. Benzodiazepines are used as
a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
8. An amide local anesthetic drug is
a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
9. The enzyme involved in conjugation reactions are
a) Transferases b) Amidases c) Hydroxylases d) Reductases
10. Univalent replacement drug in bioisosterism
a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
11. The chemical name of sulfonamide is_
12. The I.U.P.A.C name if Lidocaine is_
13. Benzodiazepines are used as_
14. Carbamazepine anticonvulsant drug is metabolized into_
15. MAO inhibitors are_
16. Halothane contains the _halogen atoms
17. Fluoxetine is a_drug
18. The I.U.P.A.C name of Phenytoin is_
19. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
20. Cotrimoxazole is a mixture of_and_ drugs
Code No: BP415 Set No. 2
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name: Hall Ticket No
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. Conjugation reactions are
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
2. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
3. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
4. Benzodiazepines are used as
a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
5. An amide local anesthetic drug is
a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
6. The enzyme involved in conjugation reactions are
a) Transferases b) Amidases c) Hydroxylases d) Reductases
7. Univalent replacement drug in bioisosterism
a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
8 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
9. Halothane contains the halogenatom as
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
10. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
11. Carbamazepine anticonvulsant drug is metabolized into_
12. MAO inhibitors are_
13. Halothane contains the _halogen atoms
14. Fluoxetine is a_drug
15. The I.U.P.A.C name of Phenytoin is_
16. Atoms, ions or molecules with similar number of_in peripheral layer is called bioisosters
17. Cotrimoxazole is a mixture of_and_ drugs
18. The chemical name of sulfonamide is_
19. The I.U.P.A.C name if Lidocaine is_
20. Benzodiazepines are used as_
Code No: BP415 Set No. 3
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name:_Hall Ticket No.
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. The non-hydrazine derivative of tricyclic antidepressant is a) Phenonthiazine b) Imipramine c) Carbamazepine
d) None d) Antihistamines d) Cinchochaine d) Reductases
2. Benzodiazepines are used as a) Antidepressants b) Antiemietics c) Sedatives
3. An amide local anesthetic drug is a) Cocaine b) Benzocaine c) Lignocaine
4. The enzyme involved in conjugation reactions are a) Transferases b) Amidases c) Hydroxylases
5. Univalent replacement drug in bioisosterism a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
6 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
7. Halothane contains the halogenatom as
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
8. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
9. Conjugation reactions are
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
10. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
11. Halothane contains the _halogen atoms
12. Fluoxetine is a_drug
13. The I.U.P.A.C name of Phenytoin is_
14. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
15. Cotrimoxazole is a mixture of_and_ drugs
16. The chemical name of sulfonamide is_
17. The I.U.P.A.C name if Lidocaine is_
18. Benzodiazepines are used as_
19. Carbamazepine anticonvulsant drug is metabolized into_
20. MAO inhibitors are
Code No: BP415 Set No. 4
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name:_Hall Ticket No.
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. An amide local anesthetic drug is
a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
2. The enzyme involved in conjugation reactions are
a) Transferases b) Amidases c) Hydroxylases d) Reductases
3. Univalent replacement drug in bioisosterism
a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
4 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
5. Halothane contains the halogenatom as
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
6. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
7. Conjugation reactions are
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
8. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
9. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
10. Benzodiazepines are used as
a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
11. The I.U.P.A.C name of Phenytoin is_
12. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
13. Cotrimoxazole is a mixture of_and_ drugs
14. The chemical name of sulfonamide is_
15. The I.U.P.A.C name if Lidocaine is_
16. Benzodiazepines are used as_
17. Carbamazepine anticonvulsant drug is metabolized into _________
18. MAO inhibitors are_
19. Halothane contains the _halogen atoms
20. Fluoxetine is a_drug
-oOo-
Code No: BP415 Set No. 1
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name: Hall Ticket No
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1 Phenytoin is a derivative of [
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
2. Halothane contains the halogenatom as [
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
3. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
4. Conjugation reactions are [
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
5. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
6. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
7. Benzodiazepines are used as [ a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
8. An amide local anesthetic drug is [ a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
9. The enzyme involved in conjugation reactions are [ a) Transferases b) Amidases c) Hydroxylases d) Reductases
10. Univalent replacement drug in bioisosterism
a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
11. The chemical name of sulfonamide is_
12. The I.U.P.A.C name if Lidocaine is_
13. Benzodiazepines are used as_
14. Carbamazepine anticonvulsant drug is metabolized into _________
15. MAO inhibitors are_
16. Halothane contains the _halogen atoms
17. Fluoxetine is a_drug
18. The I.U.P.A.C name of Phenytoin is_
19. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
20. Cotrimoxazole is a mixture of_and_ drugs
Code No: BP415 Set No. 2
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II Objective Exam Name: Hall Ticket No
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. Conjugation reactions are [
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
2. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
3. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
4. Benzodiazepines are used as [ a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
5. An amide local anesthetic drug is
a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
6. The enzyme involved in conjugation reactions are [ a) Transferases b) Amidases c) Hydroxylases d) Reductases
7. Univalent replacement drug in bioisosterism [ a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
8 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
9. Halothane contains the halogenatom as [
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
10. Haloperidol is a major tranquilizer, it belongs to the class of
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
11. Carbamazepine anticonvulsant drug is metabolized into _________
12. MAO inhibitors are_
13. Halothane contains the _halogen atoms
14. Fluoxetine is a_drug
15. The I.U.P.A.C name of Phenytoin is_
16. Atoms, ions or molecules with similar number of_in peripheral layer is called bioisosters
17. Cotrimoxazole is a mixture of_and_ drugs
18. The chemical name of sulfonamide is_
19. The I.U.P.A.C name if Lidocaine is_
20. Benzodiazepines are used as_
Code No: BP415 Set No. 3
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II
Objective Exam _
Name:_Hall Ticket No.
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. The non-hydrazine derivative of tricyclic antidepressant is a) Phenonthiazine b) Imipramine c) Carbamazepine
d) None d) Antihistamines d) Cinchochaine d) Reductases
2. Benzodiazepines are used as a) Antidepressants b) Antiemietics c) Sedatives
3. An amide local anesthetic drug is a) Cocaine b) Benzocaine c) Lignocaine
4. The enzyme involved in conjugation reactions are a) Transferases b) Amidases c) Hydroxylases
5. Univalent replacement drug in bioisosterism a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
6 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
7. Halothane contains the halogenatom as [
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
8. Haloperidol is a major tranquilizer, it belongs to the class of [
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
9. Conjugation reactions are [
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
10. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
11. Halothane contains the _halogen atoms
12. Fluoxetine is a_drug
13. The I.U.P.A.C name of Phenytoin is_
14. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
15. Cotrimoxazole is a mixture of_and_ drugs
16. The chemical name of sulfonamide is_
17. The I.U.P.A.C name if Lidocaine is_
18. Benzodiazepines are used as_
19. Carbamazepine anticonvulsant drug is metabolized into _________
20. MAO inhibitors are
Code No: BP415 Set No. 4
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD IV B.Pharmacy. I-Sem. I Mid-Term Examinations, Aug./Sept. - 2009
Medicinal Chemistry-II
Objective Exam _
Name:_Hall Ticket No.
Answer All Questions. All Questions Carry Equal Marks.Time: 20 Min. Marks: 20.
I. Choose the correct alternative:
1. An amide local anesthetic drug is [ a) Cocaine b) Benzocaine c) Lignocaine d) Cinchochaine
2. The enzyme involved in conjugation reactions are [ a) Transferases b) Amidases c) Hydroxylases d) Reductases
3. Univalent replacement drug in bioisosterism
a) Uracil b) Procainamide c) Mepyramine d) Carbanicillin
4 Phenytoin is a derivative of
a) Hydantoin b)Oxazole c) Isoxazole d) Tetrazole
5. Halothane contains the halogenatom as
a) Bromine and Iodine b) Chlorine and Fluorine
c) Bromine, chlorine and Fluorine d)Bromine, chlorine and iodine
6. Haloperidol is a major tranquilizer, it belongs to the class of [
a)Carbamates b)Butyrophenone c) Propane diol d) Phenonthiazine
7. Conjugation reactions are [
a) Phase I reactions b) Phase II reactions c) Phase III reactions d) None
8. Catechols are
a) Classical bioisosters b) Divalent bioisosters
c) Trivalent bioisosters d) Non-clasical bisisosters
9. The non-hydrazine derivative of tricyclic antidepressant is
a) Phenonthiazine b) Imipramine c) Carbamazepine d) None
10. Benzodiazepines are used as
a) Antidepressants b) Antiemietics c) Sedatives d) Antihistamines
11. The I.U.P.A.C name of Phenytoin is_
12. Atoms, ions or molecules with similar number of_in peripheral layer is
called bioisosters
13. Cotrimoxazole is a mixture of_and_ drugs
14. The chemical name of sulfonamide is_
15. The I.U.P.A.C name if Lidocaine is_
16. Benzodiazepines are used as_
17. Carbamazepine anticonvulsant drug is metabolized into _________
18. MAO inhibitors are_
19. Halothane contains the _halogen atoms
20. Fluoxetine is a_drug
-oOo-
Code No: BP415
JAWAHARLAL NEHRU TECHNOLOGY UNIVERSITY HYDERABAD B. Pharmacy IV year - I-Sem.- I Mid - Term Examinations, Aug/Sept. - 2009
MEDICINAL CHEMISTRY-II
Descriptive Exam - Question Bank Unit - I
1. List out the various factors effecting drug action. Discuss at least three factors about their role in the study of drug action?
2. Write short notes on bioisosterism?
3. Outline the various theories of drug action?
4. Write note on receptor theories of drug action?
5. Write short notes on quantitative aspects of drug action?
6. Write about drug-receptor interactions?
7. Write notes on G-Protein coupled receptors?
8. What are factors affecting drug-receptor interactions?
9. Write short notes on computer aided drug design?
10. Write about CADD and molecular modeling?
11. Write notes on Quantam mechanics and Molecular mechanics?
12. Write a applications of molecular modeling in drug design?
13. Write short notes on Q.S.A.R and its applications?
14. Write a short note on Hansch approach?
15. Write a short note on Free Wilson Analysis?
16. Write a short notes on statistical methods used in QSAR?
17. Write short notes on TSAR?
Unit-II
18. Write a short note on various mechanisms of drug action?
19. Write about the mechanism of drugs on enzymes?
20. Classify sulfa drugs with examples?
21. Write the structure of sulphaguanidine and explain their synthesis?
22. Describe the S.A.R of sulfa drugs?
23. Discuss the mode of action and uees of sulphonamides ?
24. Write notes on historical development of sulfonamides as antibacterial?
25Write general synthesis of sulphonamides?
26. Write a short notes on pharmacological and chemical aspects of any two sulphadrugs?
27. Write a synthesis, uses and mechanism of action of sulphamethoxazole?
28. Give the synthesis and uses of trimethoprim?
29. Write the structure, synthesis and uses of any sulphadrug?
30. Write short notes on cotrimoxazole?
31. Write short notes on metabolism of drugs?
32. Write note on the factors affecting the drug metabolism?
33. Write short notes on Phase-I reactions?
34. What is the role of CYP-450 enzyme in drug metabolism?
35. Write short notes on conjugation reactions?
Unit-III
36. Write short notes on chemistry of neurotransmitters?
37. What are Sedatives and Hypnotics? And how they are differentiated?
38. Define the term sedative and hypnotic? Classify sedative and hypnotic drugs with one example each?
39. Write about barbiturates their S.A.R & M.A.O?
[2]
Code No: BP415
40. Write the synthesis of phenobarbitol and Diazepam?
41. Write a detail note on structure activity relation of short acting barbiturates?
42. Write a note on phenobarbital-struture, chemical name, synthesis, therapeutic uses?
43. Write short notes on short acting barbiturates?
44. Give the mechanism of action of any two classes of sedatives?
45. Define antianxiety agents and classify them by giving examples?
46. Write a note on mechanism of action of anxiolytic drugs?
47. Write about benzodiazepines their S.A.R and general mode of action?
48. Give a detailed account of diazepam including its structure, nomenclature, pharmacokinetics, synthesis and uses?
49. Write note on alprazolam structure, chemical name, synthesis and therapeutic uses?
50. Give the different types of psychopharmacological agents with clinical uses?
51. Write note on neuroleptics and give its classification with examples and structures?
52. Write note on phenonthiazines including S.A.R &M.A.O?
53. Write the structure, chemical name, synthesis and therapeutic uses of chlorpromazine?
54. Write about butyrophenones and write notes on their S.A.R?
55. Write a note on haloperidol structure, chemical name, synthesis and therapeutic uses?
56. Write notes on clozapine structure, chemical name, synthesis and therapeutic uses?
57. Write note on oxypertine with its structure, chemical name, S.A.R and synthesis?
58. Define and classify epilepsy?
59. What are anti-epileptic drugs classify them with examples?
60. Write the structure, MAO, synthesis and uses phenytoin sodium?
61. Give an account of structure, mode of action, synthesis and therapentic uses of carbamazepine?
62. Write the synthesis of valproic acid and ethosuximide?
63. Write a note on the psychological disorder depression?
64. Define antidepressants? Classify antidepressant drugs gives suitable examples?
65. Write a note on the monoamino oxidase inhibitors?
66. Write short notes on tricyclic antidepreeants?
67. Write the synthesis of imipramine and fluoxetine?
68. Write notes on selective serotonin reuptate inhibitors (SSRI) Class of antidepressants?
69. Write the synthesis of doxepine and sertraline?
Unit-IV
70. Define general anesthetics? Write their important properties?
71. Write a note on stages of anesthesia?
72. Give the classification of general anesthetics with examples?
73. Write about general anesthetics S.A.R and M.A.O?
74. Write the synthesis and uses of halothane and ketamine?
75. Define local anesthetics? Add a short note on ideal properties of local anesthetics?
76. Write short note on various methods of administration on local anesthetics and uses of each?
77. Classify local anesthetics giving examples?
78. Write short note on mechanism of action of local anesthetics agents?
79. Discuss the S.A.R of local anesthetics agents?
80. Formulate the synthesis of Lidocaine and Benzocaine?
81. Explain the mechanism of action of two classes of local anesthetics?
82. write short note on the following aspects of local anesthetics a) Pharmacokinetics b) Adverse effects c) Therapeutic uses
-oOo-
Code No: NR-415
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
IV B. Pharmacy I Semester Regular Examinations, November 2009
MEDICINAL CHEMISTRY-II
Time: 3hours Max.Marks:80
Answer any Five questions All questions carry equal marks
1.a) What is meant by receptor? List the different types of receptors and explain their biological role.
b) Explain the bio-significance of ionization of molecules with respect its bioactivity.
2. a) Write the types of biotransformation.
b) Define the terms: 'enzyme induction' and 'enzyme inhibition'.
c) List the enzymes involved in the drug inhibition highlighting their significance.
3. a) Give a note on MAO inhibitors.
b) Outline the synthesis, MOA and therapeutic uses of doxepine and sertraline.
4. Outline the synthesis, MOA, SAR and uses of following
a) Ketamine.
b) Halothane.
5. a) Outline the biosynthesis, storage and release of catecholamimes.
b) Give the synthetic protocol and mechanism of following:
i) Salbutamol.
ii) Amphetamine.
6. a) Give a comprehensive account on clinical importance of cholinomimetics.
b) Explain the bio-significance of neurochemical transmission.
7.a) Describe the SAR of a1 antagonists.
b) Describe the SAR of quinazoline P1 antagonists.
8.a) Muscarinic antagonists are contraindicated in patients with glaucoma. Explain.
b) Give the synthesis, mode of action and uses of anticholinergic drug containing
tricyclic ring system.
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