Jawaharlal Nehru Technological University Hyderabad 2009 B.Pharm Pharmaceutical Organic Chemistry-II - Question Paper

B. Pharm (JNTU (H))
Second Year (First Semester)
Regular Examination, November-2009
Pharmaceutical Organic Chemistry-II

Time: three Hours Max. Marks: 80
Note:
1) Answer any 5 ques..
2) All ques. carry Equal marks.

1) a) Write a note on Chichibabin reaction.
b) Give the resonance structures of pyridines.
c) Explain the subsequent reactions:
i) Riemer-Tiemann reaction of pyrrole.
ii) Birch reduction of thiophene.

2) a) Give the 2 general methods of preparation of imidazole.
b) Write about electrophilic substitution reactions of imidazole.

3) a) Explain the subsequent terms:
i) Diasteromers
ii) Mesomers
iii) Enantiomers
iv) Chiral center
b) Differentiate stereo selectivity from stereo specific reaction.

4) How will you convert:
a) Glucose into mannose
b) Aldose into aldonic acid
c) Galactose to galactidol
d) Aldose into aldaric acid

5) a) Define the term amino acids and classify them based upon their chemical nature.
b) Describe the acid-base properties of amino acids.

6) a) Write about analysis of oils and fats.
b) Give the significance of hardening of oils and oxidation. Polymerization of oils.

7) a) Explain the preparation of xanthine derivatives by Traubes method.
b) Define the subsequent terms:
i) Nucleic acids
ii) Nucleosides
iii) Nucleotides

8) a) Name the reaction involved in the conversion of amide into amine and provide its reaction mechanism.
b) Enlist the synthetic importance of Michael addition reaction.

Earning:   Approval pending.