Jawaharlal Nehru Technological University Hyderabad 2008 B.Pharm Pharmaceutical Organic Chemistry-II - Question Paper

Code No. BP202
B. Pharm (JNTU)
Second Year (First Semester)
Regular Examinations, November 2008

Pharmaceutical Organic Chemistry-II

Time: three Hours Max. Marks: 80

1) Answer any 5 ques..
2) All ques. carry equal marks.

1) What happens when:
a) Pyrrole is treated with H2, Ni, at 250°C
b) Discuss the structure and nomenclature of Pyrrole. (8+8)
2) Explain the following: 4-bromo-l-Methyl Imidazole treated with n-BuLi/–78°C than DMF provide C5H6N2O carrying out the identical sequence but allowing the solution to warm to 0° before addition of DMF gave an isomeric product. (16)
3) What are conformational isomers/illustrate your ans using ethane and cyclo-hexane as examples? (16)
4) a) Discuss the objections advanced against open chain formula of glucose.
b) How does the ring structure in general overcome the objections?
c) Deduce the nature of the ring.
5) a) Define and classify amino acids with suitable examples.
b) How do proteins undergo denaturation? Add a note on Pharmaceutical importance of amino acids.
(8+8)
6) a) List out the important cardiac glycosides with structures and add a note on the properties and actions of glycone and aglycone parts respectively.
b) How do you distinguish oils and fats? describe saponification value, acid value and iodine values and their significance. (8+8)
7) a) Write the structures for 4 purine derivatives, and mention their major therapeutic applications.
b) Give a detailed account on the structures of DNA and RNA. (6+10)
8) Write the mechanism and synthetic applications for the following:
a) Michael addition reaction
b) Mannich reaction.

Earning:   Approval pending.