Jawaharlal Nehru Technological University Hyderabad 2009-1st Sem B.Pharm IV - BPharmacyRegular s, BIO-PHARMACEUTICS & PHARMACOKINETICS - Question Paper

JNTU HYDERABAD IV - B. Pharmacy I Semester Regular Examinations, November 2009 BIO-PHARMACEUTICS & PHARMACOKINETICS

ans any 5 ques..
All ques. carry equal marks.
1. a)What are the various pharmacokinetic parameters to be considered in
designing a dosage regimen?
b) describe and discuss such pharmacokinetic parameters.
2.a) What is dissolution? discuss different theories of dissolution
b) explain the parameters that influence rate of dissolution of drug.
3. discuss the structure and mode of penetration of drug through subsequent
barriers.
i) Simple capillary endothelial barrier
ii) Cell membrane barrier
iii) Blood cerebrospinal fluid barrier
iv) Placental barrier.
4.a) What kind of modifications are observed normally in body constituents in several
Physiological and pathologic conditions? How do they affect drug binding?
Explain.
b) elaborate the various factors related to protein and other binding
components that influence protein drug binding? discuss.
5. a) How do you determine Ka by method of residuals?
b) elaborate the applications and limitations of method of residuals?
c) The above method works best when difference ranging from Ka and KE is large
Explain.
6. a) What do you mean by inter subject variability? elaborate the causes of inter
subject variability? Explain?
b) How do you adjust the dose based on total body clearance and elimuafion
rate constant and
7. a) How do you determine the bio availability of a drug product Using plasma
data.
b) What do you understand by the term absolute and relative bioavailability.
c) What is bioavailable fraction? How do you express?
8. a) Hosi do you correlate invitro drug dissolution with in bio availability?
b) define about dissolution rate test apparatus and its significance

Earning:   Approval pending.