Jawaharlal Nehru Technological University Hyderabad 2009-1st Sem B.Pharm IV BPharmacyRegular s, MEDICINAL CHEMISTRY-II - Question Paper

JNTU HYDERABAD IV B. Pharmacy I Semester Regular Examinations, November 2009 MEDICINAL CHEMISTRY-II

1 .a) What is meant by receptor? List the various kinds of receptors and
discuss their biological role.
b)Explain the bio-sigmficance of ionization of molecules with respect its
bioactivity.

2. a) Write the kinds of biotransformation.
b) Delne the terms: 'enzyme induction' and 'enzyme inhibition'.
c) List the enzymes involved in the drug inhibition highlighting their
significance.

3. a) provide a note on MAO inhibitors.
b) Outline the synthesis, MOA and therapeutic uses of doxepine and sertraline.

4. Outline the synthesis, MOA, SAR and uses of subsequent
a) Ketamine.
b) Halothane.

5. a) Outline the biosynthesis, storage and release of catecholamimes.
b) provide the synthetic protocol and mechanism of following:
i) Salbutamol.
ii) Amphetamine.

6. a) provide a comprehensive account on clinical importance of cholinomimetjcs.
b) discuss the bio-signiflcance of neurochemical transmission.

7.a) define the SAR of a1 antagonists.
b) define the SAR of quinazoline /3 antagonists.

8.a) Muscarinic antagonists are contraindicated in patients with glaucoma.
Explain.
b) provide the synthesis, mode of action and uses of anticholinergic drug
containing tricyclic ring system.

Earning:   Approval pending.