Dr MGR Educational and Research Institute 2011 M.B.B.S SECOND Revised (Non-Semester) Regulations III - GENERAL PATHOLOGY AND HAEMATOLOGY Q.PCode: 524063 - Question Paper

August 2011
SECOND M.B.B.S. DEGREE exam.
Revised (Non-Semester) Regulations
Paper III - GENERAL PATHOLOGY AND HAEMATOLOGY
Q.P. Code: 524063
Time : 3 hours Maximum : 100 marks
I. Essay ques. : (2 x 15 = 30)

1. describe inflammation. Write in detail about the vascular and cellular modifications in
inflammation.

2. 40 yrs female c/o loss of weight, huge splenomegaly with peripheral blood white blood cell count of more than one lakh cells/cc
a. What is the probable diagnosis?
b. elaborate the characteristic peripheral smear findings?
c. What is the course of the disease?
d. What is the chromosomal abnormality involved?

II. Write Short notes on : (10 x five = 50)

1. Classify pigments and write about Lipofuschin.

2. Write about results of acute inflammation.

3. Growth factors.

4. Hybridisation techniques to detect genomic alterations.

5. Antibody mediated hypersensitivity.

6. Molecular basis of cancer.

7. Immunology of Leprosy.

8. Primary myelofibrosis.

9. Hemophilia A.

10. Peripheral smear and Bone marrow findings in Multiple Myeloma.

III. Short Answers Questions: (10 x two = 20)

1. describe metaplasia and provide 2 examples.

2. Antiphospholipid antibody syndrome.

3. Mention 4 X linked recessive disorders.

4. Mention 4 special stains for Amyloid.

5. Lead and blood and marrow modifications.

6. 4 infections associated with AIDS.

7. Hamartoma.

8. Prions.

9. 4 Systemic effects of inflammation.

10. Hyper IGM syndrome.

Earning:   Approval pending.