Dr MGR Educational and Research Institute 2011 M.B.B.S FIRST Revised (Non-Semester) Regulations VI - BIOCHEMISTRY - II Q.PCode: 524056 - Question Paper

August 2011
FIRST M.B.B.S. DEGREE exam.
Revised (Non-Semester) Regulations
Paper VI - BIOCHEMISTRY - II
Q.P. Code: 524056
I. Essay ques. : (2 x 10 = 20)

1. What is cloning? Mention the different kinds of cloning. define in detail
the steps involved in recombinant DNA technology.

2. define the role of plasma and renal buffers in maintaining acid base homeostasis.

II. Write short notes on : (10 x five = 50)

1. Purine salvage pathway.

2. discuss the kinds and functions of immunoglobulins.

3. Phenylketonuria.

4. Fluorosis.

5. Serum protein electrophoresis.

6. Cell cycle.

7. Role of Parathormone in Calcium, Phosphate homeostasis.

8. describe Xenobiotics and add a note on the different detoxification reactions.

9. Mutation.

10. Secondary structure of protein.

III Short ans ques. : (15 x two = 30)

1. Urea cycle disorders reason orotic aciduria. discuss

2. Acidosis causes hyperkalemia. Why?

3. describe frameshift mutation with an example.

4. We need 2 primers for polymerase chain reaction. Justify.

5. Mechanism of action of chloramphenicol.

6. Mention the aminoacids which take part in 1 carbon pool

7. Mention the enzymes which require selenium as cofactor.

8. Lesch nyhan syndrome presents with hyperuricemia. discuss.

9. Hypothyroidism presents with hypercholesterolemia. Why?

10. Histidine load test.

11. Mention 2 tumour markers and specify the diagnostic application

12. M band

13. Beer Lambert's legal regulations

14. Mention two transmethylation reactions.

15. Enzyme deficiency in albinism. Mention 2 clinical features

Earning:   Approval pending.