Kerala University 2009 M.B.B.S Second Professional , PHARMACOLOGY ( – II) - Question Paper
Illlllllllllllll (Pages : 4) 2106
Reg. No. :.....................................
Name :..........................................
Second Professional M.B.B.S. Examination, June 2009 PHARMACOLOGY (Paper - II)
Time : 2 Hours Max. Marks : 40
SECTION - A
I. Multiple choice questions (single response type) : (/ x8=4 Marks)
Instructions : a) Do not write anything on the question paper.
b) Write your Register Number in the sheet provided.
c) Select one most appropriate response and encircle the corresponding alphabet against each question number in the answer sheet provided.
1) Glucocorticoids are contra indicated in
a) Organ transplantation b) Asthma
c) Lymphoma d) Hypertension
2) Leuprolide is used in the treatment of
a) Ovarian Cancer b) Breast Cancer
c) Prostatic Cancer d) Osteogenic Sarcoma
3) Ethambutol shows the typical adverse effect of
a) Neurotoxicity b) Myelotoxicity
c) Optic Neuritis d) Nephrotoxicity
4) Insulin resistance is declared when daily requirement of insulin exceeds
a) 50 units b) 100 units c) 200 units d) 300 units
P.T.O.
5) Amongst the anticancer agents given below, the least toxic is
a) 1-asparginase b) Bleomycin c) Methotrexate d) Vincristine
6) The antibacterial that shows sequential blockade is
a) Cotrimoxazole b) Ciprofloxacin
c) Capreomycin d) Clotrimazole
7) The preferred macrolide in peptic ulcer is
a) Erythromycin b) Roxithromycin
c) Clarithomycin d) Azithromycin
8) Which of the following drugs shows immunostimulant activity ?
a) Cyclosporine b) Tarcolimus c) Levamisole d) Paclizumab
II. Match the following : (2 x8=4 Marks)
|
1) Erythromycin |
a) |
Nosocomial Infections |
|
2) Cefotaxime |
b) |
Clostridium Welchii |
|
3) Penicillin G |
c) |
Mycobacterium tuberculosis |
|
4) Sparfloxacin |
d) |
Corynebacterium diphtheriae |
|
e) |
Pseudomembranous colitis | |
|
1) Zanamivir |
a) |
Inhibit Squalene Epoxidase |
|
2) Terbinafine |
b) |
Inhibits M. protein of influenza |
|
3) Rifampicin |
c) |
Inhibito DNA dependent RNA polymerase |
|
4) Cyclophophamide |
d) |
Inhibit Mitosis |
|
e) |
Alkylation |
III. Draw and label, a schematic diagram of bacterial protein synthesis and mention the site of action of : (1++=2)
1) Streptomycin 2) Tetracycline.
1) Why is ergometrine preferred for post partum haemorrhage ?
2) Mention the uses of anabolic steroids ?
3) What are the uses of cotrimoxazole ?
4) Enumerate the newer insulins.
V. Write short notes on : (2x3=6 Marks)
1) Antipseudomonal penicillins
2) Treatment of Lepra reactions
3) Protease Inhibitors.
SECTION - B
VI. Read the passage and answer the following questions : (1+2+2+2+3=10)
A 25 year old, married woman, was admitted to the ward with evening rise of low-grade fever, cough, with expectoration. On examination general condition is weak, BP 110/60 mm/Hg, Temperature 100 F. Respiratory system shows bronochophony+, tactile vocal fremitus+. Other systems are normal. X-ray of chest shows cavity on apex of right lung.
1) What is your likely diagnosis ?
2) Describe the treatment schedule used for this condition.
3) In order to avoid pregnancy, patient takes oral contraceptive pills. After 3 months, she comes with amenorrhea. Explain and advice.
4) Mention four drugs that can be given for resistant cases.
5) What is the advantage of combination chemotherapy in this context ?
Short answer questions :
Give the pharmacological basis for the following :
VII.
1) Griseofulvin in onychomycosis.
2) Probenecid and Penicillins are given together.
3) Ondansetron is given for cisplatin induced vomiting.
4) Lugols iodine is given for hyperthyroidism.
Write short notes on :
(2x3=6 Marks)
VIII.
1) Metronidazole
2) Bulk Laxatives
3) Gonadotropins.
|
Attachment: |
| Earning: Approval pending. |
