Kerala University 2009 M.Sc BioTechnologyComputational Biology , COB 523 : COMPUTATIONAL PROTEOMICS & METABOLOMICS - Question Paper
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Second Semester M.Sc. Computational Biology Examination, June 2009 COB 523 : COMPUTATIONAL PROTEOMICS & METABOLOMICS
Time : 3 Hours Max. Marks : 60
PART - A
Answer all questions, each carries 2 marks. Answer in 3-4 sentences only/or to point.
1. What is EIIP ?
2. Explain the term propensity.
3. Briefly explain X-ray crystallography.
4. Mention any two applications of molecular dynamics.
5. What is threading ?
6. What do you mean by metabolic profiling ?
7. What do you mean by the tertiary structure of protein ?
8. Explain the term meander and cross over in SCOP classification.
9. What do you mean by tertiary structure ?
10. List any four tools used for protein function prediction. (2x10=20 Marks)
PART - B
Answer any 8 questions. Each carries 5 marks.
11. Explain SCOP and CATH classification of protein.
12. What are the theories behind the purification and isolation of proteins ?
13. Explain the term molecular dynamics.
14. Describe the features of GOR method for protein secondary structure prediction.
15. Explain the following terms
a) Alpha helix
b) Beta strand.
16. What are the key applications of metabolomics ? Discuss.
17. Predict which regions of the following peptide form alpha helices and beta sheets. Use Chau-Fasman algorithm.
FVNQHLCGSH
18. Discuss homology modeling with reference to a popular tool.
19. Explain the following terms :
a) Edmann degradation
b) Metabolic profiling
c) Metabolic fingerprinting
d) Isoelectric focusing
e) Western blotting.
20. Discuss in detail various facilities available in Protein Data Bank. (5x8=40 Marks)
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