Kerala University 2009 B.Pharm Second Year, 4, Pharmaceutical Chemistry- Biochemistry - Question Paper

part – A
I. discuss the subsequent :
a) Mutagenesis
b) Transamination
c) Sphingolipids
d) Hyperbilirubinemia
e) Catecholamines.
II. Write notes on :
i) ß -oxidation and its energetics
ii) Electron transport chain.
III. discuss the biosynthesis of
a) DNA and its replication
b) Ketone bodies and their utilisation.
IV. discuss the mechanism of action and clinical significance of enzymes.
V. a) discuss the hormonal regulation of blood sugar level.
b) elaborate essential fatty acids ? Add a note on its significance.

part – B
VI. discuss citric acid cycle and its energetics. provide the ambibolic role of it.
VII. Briefly write on :
a) Biosynthesis of urea
b) Metabolism of phenyl alanine and tyrosine.
VIII. i) discuss how RNA is biosynthesised.
ii) Write briefly on gene expression.
IX. How prostaglandins are synthesised ? Indicate their importance as local hormones.
Mention the effects of drugs acting on this pathway.
X. a) discuss the pentose phosphate pathway with its significance.
b) Write briefly on gluconeogenesis and glycogenolysis.

Earning:   Approval pending.