Biju Patnaik University of Technology 2008-8th Sem B.Pharm Bioassays PH.E5 - Question Paper
Answer Question No. 1 which is compulsory and any five from the rest.
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The figures in the right-hand margin indicate marks.
1. Answer the following questions in brief:
2x10
(a) Explain fiducial limits.
(b) Why mean is a better parameter than mode and median as a measure of central tendency ?
(c) Give an example for bioassay in humans.
(d) In which bioassay twincross over design is followed ?
(e) Explain about LAL test for parentuals.
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(f) Write an example for androgen bioassay.
(g) Write the details of digitalis bioassay by guineapig method.
(h) How do you carry out the bioassay of an united we stand,., antagonist?
(i) Rabbit head drop method is an example for bioassay of what drug ?
(j) How is histamine biologically stander-dised by in vitro method ?
2. Define bioassay ? What are its advantages and disadvantages ? 10
3. Describe the microbiological assay of Vitamin B12. 10
4. Name the models used for the determination of the pressor activity of substances. How is adrenaline biologicals standardised ? 10
5. Write the principles for the bioassay of : 10
(a) Heparin
(b) Vitamin D
(c) Acetylcholine
(d) 5HT.
6. Write short notes on the following : 10
(a) Measures adopted to minimise biological variation in standardisation.
(b) Measures used to improve sensitivity of bioassays.
PH. E.5 3 P.T.O.
7. Write short notes on the bioassay of: 10
(a) Oxytocin
(b) Gonadotrophins.
8. Write in detail about culture-sensitivity test conducted for selection of proper antibiotic for the treatment of infection. 10
PH. E.5 4 -C
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