Biju Patnaik University of Technology 2008-8th Sem B.Pharm Bioassays PH.E7 - Question Paper
Total number of printed pages -4 B. Pharm
PH.E7Eighth Semester Examination - 2008 BIOASSAYS Full Marks-70
*S
Time: 3 Hours
Answer Question No. 1 which is compulsory and any five from the rest.
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The figures in the right-hand margin indicate marks.
1. Answer the following questions : 2*10
(a) What is clinical trial?
(b) Name the test organism used for microbiological assay of streptomycin.
(c) What are the advantages of Bioassay ?
(d) Name the activity assayed in isolated mouse heart during the bioassay of acetylcholine.
(e) What do you mean by dose response curve?
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(f) Name two preparations used in bioassay of adrenaline.
(g) What is the principle of bioassay ?
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reunited WE stand,., (h) Name the activity assayed for bioassay of
antibiotics.
(i) What is the activity assayed in anaesthetised and atropinized cat for bioassay of histamine ?
(j) What is the difference between potency and efficacy ?
Describe the different methods of microbiological assay. Write a short note on microbiological assay of vitamin B12. 6+4
Write a note on bioassay of antagonists. Briefly discuss the bioassay of mepyramine. 5+5
Discuss any two methods of bioassay of Digitalis. 10
Briefly comment on: 5x2
(a) Biological variation and standardization
(b) Design of Bioassay.
Discuss any two methods of bioassay of Insulin.
10
Define bioassay. What are the types of bioassay ? Write a note on 3-point and 4-point bioassay. 1 +3+3+3
8. Write the preparation used and activity assayed in bioassay of : 2.5x4
(a) 5-hydroxy tryptamine
(b) Corticotrophin
(c) Progesterone
(d) Oxytocin.
PEEE 5405 5 P.T.O. PEEE 5405 6 Contd.
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