Biju Patnaik University of Technology 2008-6th Sem B.Pharm Pharmaceutical Chemistry-VII - Question Paper
Total number of printed pages - 4 (b)
Sixth Semester Examination - 2008PHARMACEUTICAL CHEMISTRY - VII (Medicinal Chemistry - II)
(c)
(d)
(e)
(f)
(g)
(h) (i) (j)
Full Marks - 70
Answer Question No. 1 which is compulsory and any five from the rest.
The figures in the right-hand margin indicate marks.
1. Answer the following questions in brief :
2x10
(a) Write an example (with structure and nomenclature) of Dibenzazepines and mention its therapeutic use.
Give the basic differences between General Anaesthetics and Local Anaesthetics.
Write the structure and nomenclature of a drug which is used both as Antiviral agent and Antiparkinsonism agent.
Name two steroidal anti-inflammatory drugs.
Give the structure of a calcium channel blocker having a dihydropyridine ring.
Write the structure and name of a nonsteroidal synthetic estrogen.
Write the mode of action of alprazolam.
Write the differences between Hypnotics and Sedatives.
What are androgens and anabolic agents ?
Write the structure and therapeutic uses of imipramine.
What are opioid analgesics ? Classify them. Write the synthesis of Methadone and Pethidine with their mode of action.
1+1+4+4
Write the synthesis and therapeutic uses of the following drugs : 3+3+4
(a) Glutethimide
(b) Lignocaine
(c) Furosemide.
Write short notes on : 5+5
(a) Antiparkinsonism drugs
(b) Carbonic Anhydrase Inhibitors.
(a) Describe how the structural changes in thiazides can be brought in a drug to enhance its diuretic activity. 6
(b) Outline the synthesis of diazepam. 4
6. (a) Write the synthesis and therapeutic uses
of Clonidine and Haloperidol. 6
(b) Classify the various barbiturates with examples on the basis of their onset and duration of action. 4
7. Write short notes on : 5+5
(a) Mercurial diuretics
(b) CNS stimulants.
8. (a) Define and classify the local
anaesthetics. 3
(b) Write the mode of action, therapeutic uses and synthesis of progesterone from diosgenin. 7
PH. 6.3 4 -C
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