Vinayaka Missions University 2007 B.Tech Biotechnology B.E- - Question Paper

BIOINFORMATICS
UNIT I
PART A
1. Define Bioinformatics
2. What are the 3 sub disciplines within Bioinformatics?
3. What are the aims of Bioinformatics?
4. What is UNIX?
5. Write the command for changing the Password.
6. Write the command for changing Permission.
7. What is TCP?
8. Define HTML.
9. Expand HTTP.
10. What are the major Web browsers?
11. What is e-mail?
24. Expand and discuss WWW?
25. Write any 4 available Search engines.
PART B
1. Discuss about the different applications of Bioinformatics.
2. Write short notes on
a. Kernel
b. Shell
3. List out different UNIX commands and its descriptions.
4. Explain in detail about TelNet and its applications.
5. Write short notes on
a. FTP
b. HTTP
6. Explain the Browser architecture and discuss the kinds of documents in WWW.
7. How does e-mail work?
8. Write an essay on the Internet.
9. What is the role of Computer science in Bioinformatics – Explain?
10. Justify the need of Bioinformatics – discuss.
UNIT II
PART A
1. What is a Database?
2. How does Database perform?
3. What are the kinds of Databases?
4. What is the significance of DBMS?
5. Write short notes on PDB
6. Name few Structural databases.
7. What is SRS?
8. List out few Databases for Proteins.
9. What is the significance of Biological databases?
10. What is the significance of PROSITE?
11. Write short notes on Pubmed.
12. Expand a. NBRF b. EMBLE-EBI c. RCSB d. DDBJ
13. What do you meant by subsidiary database?
14. Explain HGP.
15. What are the uses of Data storage?
PART B
1. Discuss in detail about the primary sequence data bases with examples
2. Explain the different kinds of Databases with an example.
3. Discuss about the aim and scope of Biological databases.
4. Explain how the data are retrieved from Database.
5. What are Protein databases? List out the Protein databases.
6. Write short notes on (i) Swiss-Prot
a. PIR
b. DDBJ.
7. What are Nucleotides and discuss the available Nucleotides databases.
8. Write short notes on (i) EMBL
a. EBI
b. NCBI.
9. Give a detailed note on Structural database with examples.
10. Give a detailed account on Derived and Genome database.
UNIT III
PART A
1. describe Pair wise alignment.
2. describe Global alignment
3. describe Local alignment
4. What is a Gap?
5. What is Gap Penalty?
6. describe Dot matrix.
7. provide any 2 tools for Dot matrix.
8. Perform Dot matrix for the provided 2 sequences.
a. GTTCAGCTGCGTAC
b. GATCAACTGACGTA
9. Define multiple sequence alignment.
10. Name any 2 Multiple sequence alignment programme.
11. What are the applications of multiple sequence alignment?
12. Define BLAST.
13. Name any 2 kinds of BLAST.
14. What is FASTA?
15. Define PAM matrix.
16. Define BLOSUM matrix.
17. Write notes on Needleman Wunsch Algorithm.
PART B
1. Define Pair wise alignment. explain on Local and Global alignment in detail with example.
2. What is Multiple sequence alignment? explain in detail.
3. What is Dot matrix? explain in detail.
4. Define BLAST. explain in detail about the BLAST algorithm
5. What is FASTA? explain in detail about the FASTA algorithm.
6. Discuss about the subsequent matrix
a. PAM matrix.
b. BLOSUM matrix.
8. Briefly discuss the aminoacid substation matrices.
9. Explain the Principle of Needleman Wunsch Algorithm.
10. Explain the Principle of Smith waterman Algorithm.
UNIT IV
PARTA
1. What is Phylogenetics?
2. What is the need to learn about Phylogenetics?
3. What are the basic elements in a Tree?
4. What is Maximum Parsimony method?
5. What is the difference ranging from Orthologs and Paralogs?
6. Define Neighbor joining method?
7. What is Genetics Algorithms?
8. What is Distance based method in Phylogenetic analysis?
9. Name any 2 Tree valuation methods.
10. What is Boots trapping?
11. Name any 2 automated tool for Phylogenetic analysis.
12. What are the advantages of Phylogenetic analysis?
13. Give a brief note on Progressive Alignment
14. Give the important online tools used for Phylogenetic analysis.
15. Give a note on the Offline software’s of Phylogenetics.
PART B
1. What are the 2 major kinds of Cladistic method? explain in detail about the methods.
2. Discuss in detail about Tree construction.
3. Discuss in detail about Tree building and Tree valuation methods.
4. Discuss in detail about the subsequent
a. Distance based method
b. Maximum likely hood method.
c. Bootstrapping method.
5. Discuss in detail about the different Phylogenetic analysis software for Data modeling and Tree building.
6. Write short notes on
a. Homologous
b. Orthologous
c. Xenologs
d. Paralogs.
UNIT V
PART A
1. What is Pharmacogenomics?
2. What is cheminformatics?
3. Define Pharmacophore.
4. What is Human Genome project?
5. List out the major Bioinformatics industries.
6. Expand QSAR.
7. Write the applications of Bioinformatics in Agriculture?
8. What do you meant by SNP?
9. Define rational drug design.
10. What is DNA chip?
PART B
1. What are major role involved by the IT companies and the demerits towards Bioinformatics?
2. What is Bioinformatics? explain about the role of Bioinformatics in Pharmaceutical companies.
3. Discuss about the application of Bioinformatics in different field.
4. Explain the Applications of Bioinformatics in Proteomics.
5. Enumerate the role of Bioinformatics in Agriculture.
6. Explain the role of Data mining in Bioinformatics.

Earning:   Approval pending.