Vinayaka Missions University 2009 B.E Bioinformatics / - Question Paper

SI. No. E4955 Sub. Code: 3540537

B. E. DEGREE EXAMINATION

Fifth Semester

BIO INFORMATICS

COMPUTATIONAL BIOLOGY

Time: Three Hours Maximum: 80 Marks

Answer ALL Questions

PART-A (10 x 2 = 20 Marks)

1.      What is sequence alignment?

2.      What are the methods of motif finding?

3.      What do you mean by gap open penalty?

4.      What are the values given to match, mismatch and gap?

5.      What is Iterative method?

6.      What do you mean by Profiles?

7.      How can we predict RNA secondary structure?

8.      What do you mean by signal recognition?

9.      What do you mean by Gene synteny?

10.  Where do we find the Conservative region?

 

PART-B (5 x 12 = 60 Marks)

11. a) Give detailed notes on the Expression Profiling and its methods.

OR

b) Explain algorithms and their uses in computational biology.

12. a) Discuss about Scoring matrices and its methods.

OR

b) Discuss the significances of sequence alignment in detail.

13. a) Give justification for the pattern searching and matching in detail

OR

b) Explain the states of Markov chain and discuss about its process.

14. a) Discuss about the neural networks and its methods.

OR

b) Discuss the evaluation methods in gene prediction

15. a) Discuss the methods used for predicting genome

OR

b) Explain about the transposable elements.

.

******