University of Delhi 2010-2nd Year M.Tech Information Technology 1st nd chemistry of life process and naturally occurring bioactive compounds UNIVERSITY - Question Paper
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M, Tech. / II Scm.
CHEMICAL SYNTHESIS AND PROCESS TECHNOLOGIES Paper - 204 - Chemistry of Life Process and Naturally Occurring Bioactive Compounds
J
Time 3 hours Maximum Marks 70
(Write your Roll No on the top immediately on receipt of this question paper)
Use separate answei script for Section A & B
SECTION A (Attempt all questions)
Q 1 (a) What was the contribution of Rosalind Franklin in DNA reseaich (1)
(b) What forces are responsible for the stability of DNA double helical structure and physiological conditions9 (2)
(c) Write main reactions and key intermediates of urea biosynthesis Write the role of carbamoyl phosphate svmhase I in urea cycle 9 (3)
(d) Write a short overview on p-o\idation of fatty acids (2)
(e) Acetyl CoA plays a central role in metabolism Justify the statement (2)
(f) Justify that oxygen evolved in photosynthesis comes form water and not fiom carbon dioxide (1)
Q 2 (a) Which component of DNA absorbs U V-radialion9 What are the possible structures formed by the DNA sequence 5'-AGATCTTTTAGATCT-3' 9 Draw a typical thermal denaturation profile of DNA double helix (3)
(b) DNA is polymorphic Justify the statement (2)
(c) What are the crucial steps regulating the ketogenesis 9 (I)
(d) What is the role of plastoquinone and cytochrome bf m photosynthesis 9 (2)
Q 3 (a) Write short nots on any three of the following (2+2+2)
(i) G-C base-pair
(n) Structure and function of t-RNA
(in) Glutathione peroxidase protects erythrocytes against hemolysis
(iv) Structure and function of TPP and Biotin
(v) Calvin cycle
(b) Give salient features of a-helix of proteins (2)
Q (4) (a) Write key steps in the biosynthesis of long-chain fatty acid (2)
(b) What is the difference between transamination and oxidative deamination9 How s ammo acid catabolism initialed by transamination9 Give examples (2)
(c) What do you understand by 1 2 and 3 structures ot protein'7 (1)
(d) Explain the role of transaldolase and transkctolase in pentose phosphate pathways (2)
(e) The conversion of pyruvate into phosphoenolpyruvate begins with the formation of oxaloacetate Comment (0
SECTION B (Attempt any three questions)
1(a) Give the synthesis of vitamin A,, using fiionone and ethyl / -bromocrotonate as starting materials.
(b) (i) Write down the structure of (+) P -tocopherol. How many chiral centres are there in it and what is its configuration ?
(ii) Vitamin E, a phenol, is the major compound in the blood responsible for preventing oxidative damage by free radicals.
Write down the structures of A & B.
(d) What are reductones ?Explain with the help of an example.
(3,4,3,2)
2.(a) Using bases (B:) and acids (+BH) , provide a pyridoxal phosphate-catalysed mechanism for decarboxylation of an o{- amino acid. How this transformation is utilized ?
(b) Thiamine is decomposed quantitatively into two compounds, when treated with a sodium sulphite solution saturated with sulphur dioxide:
caHt8c<2N4S + Naso- CHNOS +
GO CB)
Establish the structures of A and B
(c ) (i) Wgte down the important features regarding the structure of bpiolecule vitamin B
(ii) Give the name and structure of the two biological active geometrical isomers of vitamin A
(d) What is the importance of natural products in drug discovery ? Explain with suitable examples. (3,3,3,2)
(a) (i) Complete the following reaction
O O o
m
Ii II ._> P
CH3CS-ACP+HOCCHzCS-ACP ---? f
(ii) Write the overall equation for the biosynthesis of palmitic acid.
(b) Propose a mechanistic pathway for the biosynthesis of:
(i) o( -terpineol (it) squalene
(c) Write down the names and structures of principal starting materials for secondary metabolism and the nature of products obtained from them.
(d) Write down the biosynthesis of:
(i) Hygrine(ii) Cuscohygrine. (3,3,2,3)
4.(a) Given below are the reactions of riboflavin:
TibofWm B
OHO coH + C(( H Nxo
Write down the structures of A,B,C,D &E.
(b) (i) With ATP, glucose undergoes an energetically favourable reaction
to yield glucose-6-phosphate plus ADP. Explain.
(ii) Give two reactions that have been postulated for the biosynthestic conversion of amino acids into alkaloids.
(c) The vitamin thiamine is used as a coenzyme for the metabolic decarboxylation of pyruvate to acetyl-coenzyme-A. Give the mechanism of the reaction.
(d ) Write a note on any two of the following:
(i) Down-stream processes in case of isolation of bioactive molecules,
(ii)Herbal preparations
(iii) Classification of water & fat soluble vitamins
(3,3,3,3)
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