Manipal University 2009 M.Pharm Part-I - Question Paper
Manipal University
M.Pharm Part-I Degree Examination- May/June 2009
Subject: Modern Molecular Biology and Immunology(PBT 604)
Specialisation: Pharmaceutical Biotechnology
MANIPAL UNIVERSITY M. PHARM. PART-I DEGREE EXAMINATION - MAY/JUNE 2009 SUBJECT: MOLECULAR BIOLOGY AND IMMUNOLOGY (PBT 604) SPECIALIZATION: PHARMACEUTICAL BIOTECHNOLOGY
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Reg. No. |
Monday, June 01, 2009
Time: 10:00-13:00 Hrs.
Max. Marks: 100
jeS Answer all the questions.
IA. With Hemoglobin as an example, explain developmentally controlled complex gene families and explain the different regulatory units in yeast.
IB. What is GRB-2? What is its function? What role do the SH2 & SH3 domain plays in the function of GRB-2?
(10+10 = 20 marks)
2A. Explain in detail, how MPF regulates the following functions in a cell:
i) Breakdown of nuclear envelope.
ii) Chromosome condensation.
2B. Write a note on viral oncogenesis.
(10+10 = 20 marks)
3A. How do antibodies, which all have the same shape, recognize antigens of a wide variety of different shapes? Discuss.
3B. Enumerate the cells involved in antigen presentation and explain how an antigen is processed and presented to T cell receptors.
(10+10 = 20 marks)
4A. Explain the role of complement system in immunity.
4B. Explain any three methods for the determination of cytotoxicity, mentioning the advantages and disadvantages of each of them.
(10+10 = 20 marks)
5A. Explain in detail the different enzymes involved in the DNA replication and their specific function. Add a note on conservative and Semi conservative replication.
5B. Briefly outline the consequences of defective immune system.
5C. Explain briefly the etiology of autoimmune disorders.
(10+5+5 = 20 marks)
PBT 604 Page 1 of 1
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| Earning: Approval pending. |
