Manipal University 2000 Post Graduate Diploma Medical pre PG ENTRANCE - Question Paper

Ans: (a)
6. Peptide bond actual is
a. Cleaved by denaturation of protein, b. Ionizes at normal pH, c. Stable at strong pH (acidic), d. Primary structure determines biologic activation and confirmations.
Ans: (d)

Manipal A I P P G Paper 2000

7. Gene therapy is
a. Inserting normal gene in place of abnormal ones, b. development of better genes for future generations, c. Removing the abnormal gene only, d. All of the above.
Ans: (a)
8. Which is actual about porphyria
a. learn poisoning – ferrachelatase inhibition, b. Protoporhyrin oxidase is a cytosolic enzyme, c. ALA synthase requires TPP, d. Variegate porphyria – uroporphyin synthase I.
Ans: (c)
9. Risk factors for coronary artery disease are all other than
a. Increase VLDL, b. Increase HDL, c. Increase LDL, d. All of the above.
Ans: (b)

Pharmacology

1. Which of the subsequent can be provided with OCP
a. Mebendazole, b. Amoxycillin, c. Phenytoin, d. Rifampin
Ans: (a)
2. Mode of action of vigabatrin is
a. Inhibitor of GABA transaminase increasing GABA conc, b. Suppress Na+ current channels, c. Inhibit T kind Ca 2+ channel, d. None
Ans: (a)
3. Mode of action of baclofen is
a. Act as GABA receptor agonist thro hyperpolarising neurons by increasing k+ conductance and altering ca2+ flux , b. Depolarise muscle by opening Na+ channel, c. Both, d. None
Ans: (a)
4. Moricizine used as antiarrhythmic causes: -
a. Prolongation of action potential, b. reduce action potential, c. No change in action potential, d. None of the above.
Ans: (a)
5. All of the subsequent can be used against chloroquine resistant malaria other than
a. Mefloquine, b. Quinine, c. Primaquine, d. Halofantrine.
Ans: (c)
6. Ethanol elimination is a
a. Linear elimination, b. Dose dependent, c. Saturation type, d. Fixed elimination
Ans: (d)
7. Prodrug used in prostatic carcinoma with antiandrogenic action is
a. Cyproterone, b. Clomiphene, c. Danazol, d. Tamoxifen
Ans: (a)
8. Which of the subsequent is not hepatotoxic
a. INH, b.Rifampin, c. Ethambutol, d. Pyarizinamide.
Ans: (c)
9. Which of the subsequent is a best drug to stop cisplatin induced vomiting

Earning:   Approval pending.