Calicut University 2008 M.B.B.S FIRST PROFESSIONAL , TEMBER BIOCHEMISTRY – I (New Scheme) - exam paper

part A
1. provide the reactions of citric acid cyclea long with its importance and energetics.
(6+2+2 = 10 marks)
2. Write briefly on:
(a) Formation of ketone bodies and their utilization.
(b) Major fate of ammonia produced in human body.
(2x5 = 10 marks)
3. Multiple option ques. (separate sheet attached) (5 marks)
part B
4. (a) Write briefly on competitive inhibition.
(b) How is iron absorbed from the GI Tract?
(c) describe oxidative phosphorylation. Name any 4 uncouplers of oxidative
phosphorylation.
(d) Write briefly on hepatic jaundice.
(e) Write briefly on importance of dietary fibres. (5x3 = 15
marks)
5. (a) What is the diagnostic importance of serum LDH?
(b) Mention the composition of any 2 glycerophospholipids with their functions.
(c) Write briefly on any 2 glycogen storage diseases.
(d) Write briefly on Phenylketonuria.
(e) Write briefly on detoxification by conjugation. (5x2 = 10 marks)


3. MULTIPLE option ques.
BIOCHEMISTRY – Paper I

Note:1.
Do not write anything on the ques. paper.
2. Write your register number on the anser sheet given.
3. choose the improper ans and encircle the alphabet against every
ques. in the ans sheet given.
4. In the ans sheet enter the total number of your answers in the
improper box given.
5. every ques. carries ½ mark.


1. The amino acid which has maximum buffering capacity at physiological pH is:
(A) Arginine (B) Alanine
(C) Histidine (D) Glutamic acid
2. Iodoacetate inhibits enzyme by reacting with whcih particular group at the active site
of the enzyme?
(A) Amide. (B) Sulfhydry1
(C) Carboxy1. (D) Imidazole.
3. The glycosidic linkage seen in lactose is:
(A) Alpha 14
(B) Beta 14
(C) Beta 16
(D) Alpha 16
4. In an immunoglobulin molecule, the antigen binding capacity resides at the:
(A) Constant region (B) Variable region
(C) Fe (fraction crystallisable) region. (D) J (joining) piece.
5. Muscle glycogen will not serve as a precursor of blood sugar because:
(A) Phosphorylase enzyme is absent in muscle.
(B) Receptor for glucagon is absent in muscle.
(C) Glucose = six = phosphatase enzyme is absent in muscle.
(D) Glycogen is converted to lactic acid in muscle.
6. The rate limiting enzyme of de novo synthesis of fatty acids is:
(A) Acetyl CoA transacylase. (B) Acetyl CoA carboxylase.
(C) Acetyl CoA dehydrogenase (D) BHydroxy
acy1 CoA dehydrogenase.
7. Hypercholesterolemia is seen in the subsequent condiitions except:
(A) Uncontrolled diabetes mellitus (B) Thyrotoxicosis
(C) Nephrotic syndrome. (D) Obstructive jaundice
8. Blood urea level is markedly increased in:
(A) Liver diseases (B) Renal diseases
(C) Cardiac diseases (D) Protein intake.
9. Negative nitrogen balance is observed in:
(A) Pregnancy (B) Chronic fever
(C) Growth period (D) Convalescence.
10.Which of the subsequent statement is most improper with regard to BenceJones
Proteins?
(A) It is seen in urine of 80% cases of multiple myeloma.
(B) It provide a positive Benedict's test in urine.
(C) It is precipitated when heated ranging from 45° and 60 ° centigrade.
(D) If current in urine, prognosis is better.

Earning:   Approval pending.