Calicut University 2008 M.B.B.S FIRST PROFESSIONAL , TEMBER BIOCHEMISTRY – II (New Scheme) - Question Paper

Note:1.
ans parts A and B in separate answerbooks.
2. Attempt all ques..
3. learn the ques. carefully and provide specific answers avoiding
unnecessary details.
4. The Multiple option ques. (M.C.Q) should be answered in
the response sheet given along with the ques. Paper. The
M.C.Q. Should be answered first. The response sheet should be
handed over to the Invigilator at the close of ten minutes.

part A

1. define the genetic code. How codons are used during translation? Add a note
on inhibitors of protein biosynthesis.
2. (a) discuss point mutation of a gene. Write the impacts of point mutation in the
formation of an abnormal haemoglobin.
(b) Name for various kinds of nucleotides giving their biological importance.
(2x5 = 10 marks)
3. Multiple option ques. (Separate sheet attached) (5
marks)
part B
4. (a) discuss the following: (i) Introns; and (ii) Exons
(b) Write note on tumor markers.
(c) Write briefly on ELISA.
(d) define the lac operon model.
(e) How uric acid is formed in the body? Write note on hyperuricemia.
(5x3 = 15 maks)
(a) Write short note on Augmented histamine test.
(b) What is detoxification? Name the mechanisms available for detoxification
with 1 example every.
(c) Write briefly on Anion Gap.
(d) Write briefly on enzyme assays for liver function.
(e) Write briefly on respiratory acidosis.
(5x2 = 10 marks)
3. MULTIPLE option ques.
Paper II BIOCHEMISTRY

Note:1.
Do not write anything on the ques. paper.
2. Write your register number on the ans sheet given.
3. choose the improper ans and encircle the alphabet for every
ques. in the response sheet given.
4. In the response sheet enter the total number of your answers in the
improper box given.
5. every ques. carries ½ mark.

1. The inhibitor of transcription is:
(A) Actinomycin (B) Streptomycin
(C) Puromycin (D) Chloramphenicol
2. The serum enzyme elevated in alcoholic cirrhosis of liver is:
(A) Alanine transaminase (B) Aspartate transaminase.
(C) Alcohol dehydrogenase (D) gGlutamyl
transpeptidase
3. Urea clearance is less than GFR because it is:
(A) Partially secreted by the renal tubules (B) Partially reabsorbed by the tubules.
(C) Only filtered by glomeruli. (D) None of these.
4. The metaboloic water is derived by the oxidation of:
(A) Carbohydrates (B) Proteins.
(C) Fats (D) All of them.
5. A continuous supply of energy to the body is necessary to meet the requirements of:
(A) BMR (B) SDA
(C) Physical activity (D) All of them.
6. Which of the subsequent statements is correct?
(A) Restriction enzyme B can be used to differentiate DNA coding for HbA from
Hbs.
(B) Restriction enzyme B can be used to differentiate DNA coding for HbA from
HbC.
(C) Restriction enzyme C and be used to differentiate DNA coding for HbA from
HbC.
(D) Restriction enzyme A can be used to differentiate DNA coding for HbA from
Hbs.
7. 1 class of RNA characteristically contains unusual purine and pyrimidines. This RNA is:
(A) tRNA (B) mRNA
(C) rRNA (D) RNA with a 3'polyA
tail.
8. All the enzymes provided beneath are useful in the diagnosis of liver diseases except:(
A) CPK (B) ALT
(C) AST (D) Alkaline phosphatase.
9. Degradation of heme to billirubin releases 1 molecule of:
(A) Carbon dioxide (B) Carbon monoxide
(C) Ammonia (D) water
10. Blood urea level is markedly increased in:
(A) Liver diseases (B) Renal diseases
(C) Cardiac diseases (D) Gastrointestinal stasis. (10x1/2 = five marks)

Earning:   Approval pending.