Maharaja Sayaji Rao University of Baroda 2010 M.Pharm Gpat - Question Paper

GPAT 2010 ques. PAPER


Q.l The vitamin essential in tissue culture medium is
(A) Pyridoxine (B) Thiamine (C) Nicotinic acid (D) Inositol
Ans. B
Q.2 Gingkgo biloba is used for its
(A) Expectorant activity (B) Lipid lowering activity
(C) PAF antagonistic activity (D)Antidepressant activity
Ans.C
Q.3 The amount of barbaloin current in Aloe vera is
(A) <1% (B) 3.5-4% (c) 1-1.5% (D) 2-2.5%
Ans.B
Q.4 Sildenafil is used for treatment of 1 of the subsequent disorders :
(A) Systolic hypertension (B) Unstable angina
(C) Pulmonary hypertension (D) Hypertension due to eclampsia
Ans.C
Q.5 Cardiac glycosides have the subsequent configuration in the aglycone part of the steroid nucleus :
(A) 5a, 14a- 5a, 14ß- (C) 5ß, 14a- (D) 5ß,14ß-
Ans.D
Q.6 Quassia wood is adulterated with
(A) Brucea antidysentrica (B) Cassia angustifoila
C) Cinnamomum zeylanicum (D) Cephaelis ipecacuanaha
Ans.B
Q.7 Eugenol is current in
(A) Fennel (B) Tulsi (C) Cardamom (D) Coriander
Ans.B
Q.8 Which 1 of the subsequent drugs is prescribed for the treatment of Philadelphia chromosome positive
patients with Chronic myeloid Leukemia?
(A) Pentostatin (B) Methotrexate
(C) Imatinib (D) L-Asparaginase
Ans.C
Q.9 Which of the subsequent monoclonal antibodies is prescribed for patients with non-Hodgkin's
Lymphoma?
(A) Infliximab (B) Abciximab (C) Gemtuzumab (D) Rituximab
Ans.
Q.10 Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum :
(A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine
Ans. B
Q.ll Which 1 of the subsequent drugs does NOT act through G-Protein coupledreceptors?
(A) Epinephrine (B) Insulin (C) Dopamine (D) TSH
Ans.B
Q.12 Which 1 of the subsequent drugs is most effective in preventing transmission of HIV virus from the mother
to the foetus?
(A) Lamivudine (B) Zidovudine (C) Indinavir (D) Ribavirin
Ans.B
Q.13 Improvement of memory in Alzheimer's disease is brought about by drugs which increase transmission in
(A) cholinergic receptors (B) dopaminergic receptors
(C) GABAergic receptors (D) adrenergic receptors
Ans.A
Q.14 Which of the subsequent non-opioid analgesics is a prodrug?
(A) Piroxicam(B) Celecoxib(C)Nabumetone (D) Ketorolac
Ans.CPharmacophore Solutions
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Q.15 Which 1 of the subsequent drugs is NOT a typical anti-psychotic agent?
(A) Chlorpromazine (B) Haloperidol
(C) Risperidone (D) Flupentixol
Ans.C
Q.16 Which 1 of the followings is a plasminogen activator?
(A) Tranexamic acid (B) Streptokinase
(C) Aminocaproic acid (D) None of the above
Ans.B
Q.17 Myasthenia gravis is diagnosed with improved neuromuscular function by using
(A) Donepezil (B) Edrophonium (C) Atropine (D) Pancuronium
Ans.B
Q.18 Which 1 of the subsequent drugs specifically inhibits calcineurin in the activated T lymphocytes?
(A) Daclizumab (B) Prednisone (C) Sirolimus(D) Tacrolimus
Ans. D
Q.19 The chemical behaviour of morphine alkaloid is
(A) acidic (B)Basic (C) neutral (D) amphoteric
Ans.B
Q.20 At physiological pH the subsequent compound would be MOSTLY in the
(A) cationic form (B) unionized form
(C)zwitterionic form (D) anionic form
Ans.

Q.21 Which 1 of the followings is used as a mood stabilizer for bipolar disorder and also in certain epileptic
convulsions?
(A) Phenytoin (B) Lithium
(C) Sodium valproate (D) Fluoxetine
Ans.B
Q.22 An isosteric replacement for carboxylic acid group is
(A) pyrrole (B) isoxazole (C) phenol (D) tetrazole
Ans.-D
Q.23 The provided antibiotic is an example of ansamycins :
(A) Roxythromycin (B) Adriamycin (C) Aureomycin (D) Rifamycin
Ans.D
Q.24 For glyburide, all of the subsequent metabolic reactions are logical other than
(A) O-demethylation (B) aromatic oxidation
(C) benzylic hydroxylation (D) amide hydrolysis
Ans.B
Q.25 The effects observed subsequent systemic administration of levodopa in the treatment of Parkinsonism have
been attributed to its catabolism to dopamine. Carbidopa, can markedly increase the proportion of levodopa that
crosses the blood-brain barrier by
(A) increasing penetration of levodopa through BBB by complexation with it
(B) decreasing peripheral metabolism of levodopa
(C) decreasing metabolism of levodopa in the CNS
(D) decreasing clearance of levodopa from the CNS
Ans.B
Q.26 Ethambutol molecule has
(A) 2 chiral centers and three stereoisomers
(B) 2 chiral centers and four stereoisomers
(C) 2 chiral centers and two stereoisomers
(D) 1 chiral center and two stereoisomers
Ans.B
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Q.27 A compound will be sensitive towards IR radiation only when 1 of the subsequent properties undergo
transition on
(A) Polarizability (B) Dielectric constant
(C) Dipole moment (D) Refractivity
Ans.C
Q.28 X-ray crystallographic analysis of an optically active compound determines its
(A) Optical rotatory dispersive power (B) Absolute configuration
(C) Relative configuration (D) Optical purity
Ans.
Q.29 Which 1 of the subsequent statements is WRONG?
(A) A singlet or triplet state may outcome when 1 of the electrons from the HOMO is
excited to higher energy levels
(B) In an excited singlet state, the spin of the electron in the higher energy orbital is
paired with the electron in the ground state orbital
(C) Triplet excited state is more stable than the singlet excited state
(D) When the electron from the singlet excited state returns to ground state, the molecule always indicates
fluorescence phenomenon
Ans.C
Q.30 Aminotransferases usually require the subsequent for their activity :
(A) Niacinamide (B)Vitamin B12
(C) Pyridoxal phosphate (D) Thiamine
Ans.C
Q.31 Purity of water can be assessed by determining 1 of its subsequent properties instrumentally :
(A) pH (B) Refractivity (C) Viscosity (D) Conductivity
Ans.D
Q.32 Which 1 of the subsequent statements is WRONG?
(A) Carbon NMR is less sensitive than proton NMR
(B) 12C nucleus is not magnetically active
(C) Both 13C and *H have identical spin quantum numbers
(D) The gyromagnetic ratio of *H is lesser than that of1 C
Ans.D
Q.33 In the TCA cycle, at which of the subsequent enzyme-catalyzed steps, incorporation of elements of water into
an intermediate of the cycle takes place :
(A) Citrate synthase (B) Aconitase
(C) Maleate dehydrogenase (D) Succinyl Co-A synthase
Ans.C
Q.34 Humectants added in cosmetic preparations generally act by
(A) hydrogen bond formation (B) covalent bond formation
(C) complex formation (D) the action of London forces
Ans.A
Q.35 In the mixing of thymol and menthol the subsequent kind of incompatibility occurs :
(A) Chemical incompatibility (B) Therapeutic incompatibility
(C) Physical incompatibility (D) Tolerance incompatibility
Ans.C
Q.36 Bloom strength is used to check the quality of
(A) Lactose (B) Ampoules
(C) Hardness of tablets (D)Gelatin
Ans.D
Q.37 The characteristic of non-linear pharmacokinetics include :
(A) Area under the curve is proportional to the dose
(B) Elimination half-life remains constant,
(C) Area under the curve is not proportional to the dose
(D) Amount of drug excreted through remains constant
Ans.C
Q.38 In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is
(A) Schedule M (B) Schedule C (C) Schedule Y (D) Schedule H
Ans.APharmacophore Solutions
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Q.39 Thioglycolic acid-like compounds have applications in subsequent kind of cosmetic
formulations :
(A) Depilatory preparations (B) Epilatory preparations
(C) Vanishing creams (D) Skin tan preparations
Ans.A
Q.40 Which 1 of the subsequent is a flocculating agent fora negatively charged drug?
(A) Aluminium chloride (B) Bentonite
(C) Tragacanth (D) Sodium biphosphate
Ans.
Q.41 The healing agent used in hand creams is
(A) soft paraffin (B) urea
(C) bees wax (D) stearyl alcohol
Ans.A
Q.42 Measurement of inulin renal clearance is a measure for
(A) Effective renal blood flow (B) Renal drug excretion rate
(C) Active renal secretion (D) Glomerular filtration rate
Ans.D
Q.43 Highly branched 3 dimensional macromolecules with controlled structures with all bonds originating
from a central core are known as
(A) cyclodextrins (B) dextrans (C)dendrimers (D) liposomes
Ans.
Q.44 Which 1 of the subsequent is the commonly used bulking agent in the formulation of freeze dried low dose
drug products?
(A) Sodium chloride (B) Mannitol
(C) Starch (D) HPMC
Ans.
Q.45 The applicability of Noyes-Whitney formula is to define
(A) 1st order kinetics (B) Zero order kinetics
(C) Mixed order kinetics (D)Dissolution rate
Ans.D
Q.46 Which filler can NOT be used for the preparation of tablets for amine containing basic drugs toavoid
discoloration of the tablets?
(A) Dicalcium phosphate (B) Microcrystalline cellulose
(C) Starch (D) Lactose
Ans.D
Q.47 The ability of human eye using illuminated area to detect a particle is limited to
(A) 0.4 micron (B) 25 micron (C) 50 micron (D) 10 micron
Ans.
Q.48 What volumes of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol?
(A) 480 mL of 95 % and 320 mL of 45 % alcohol 4
(B) 320 mL of 95 % and 480 mL of 45 % alcohol
(C)440 mL of 95 % and 360 mL of 45 % alcohol
(D)360 mL of 95 % and 440 mL of 45 % alcohol
Ans.B
Q.49 The role of borax in cold creams is
(A) anti-microbial agent
(B) to give fine particles to polish skin
(C) in-situ emulsifier
(D) antioxidant
Ans.APharmacophore Solutions
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Q.50 select the right combination:
(A) Quinine', antimalarial, isoquinoline alkaloid
(B) Reserpine, -antihypertensive, indole alkaloid
(C)-Quantitative microscopy, stomatal number, myrrh
(D) Palmitic acid, salicylic acid , fatty acids
Ans.B
Q.51 Triterpenoids are active constituents of
(A) Jaborandi (B) Rhubarb
(C) Stramonium (D) Brahmi
Ans.D
Q.52 Alkaloids are NOT precipitated by
(A) Mayer's reagent (B) Dragendroff Reagent
(C) Picric acid (D) Millon's reagent
Ans.D
Q.53 Anisocytic stomata are current in
(A) Senna (B)Digitalis(C) Belladonna (D) Coca
Ans.C
Q.54 Bacopa monnieri plant belongs to the family
(A)Scrophulariacea (B) Leguminosae (C) Polygalaceae (D) Rubiaceae
Ans.A
Q.55 Tropane alkaloids are NOT current in
(A) Datura stramonium
(B) Erythroxylum coca
(C) Duboisia myoporoides
(D) Lobelia inflata
Ans.D
Q.56 Guggul lipids are found from
(A) Commiphora molmol
(B) Boswellia serrata
(C) Commiphora wightii
(D) Commiphora abyssinica
Ans.C
Q.57 Anexample of N-glycoside is
(A) Adenosine
(B)Sinigrin
(C) Rhein-8-glucoside
(D) Aloin
Ans.A
Q.58 1 mg of Lycopodium spores used in quantitative microscopy contains an avg. of
(A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores
Ans.A
Q.59 choose the correc: combination of drugs for the treatment of patients suffering from Hepatitis C :
(A) Interferon withRibavirin (B) Interferon with Zidovudine
(C) Interferon with Stavudine (D) Interferon with Lamivudine
Ans.B
Q.60 Aliskiren acts by
(A) inhibiting the conversion of Angiotensin I to II
(B) inhibiting the release of rennin
(C) inhibiting the binding of Angiotensin II to the receptor
(D)inhibiting the action of aldosterone
Ans.BPharmacophore Solutions
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Q.61 Digitalis toxicity is enhanced by co-administration of
(A) Potassium B) Quinidine (C) Diuretics (D) Antacids
Ans.B & C
Q.62 The rate limiting step in cholesterol biosynthesis is 1 of the followings :
(A) LDL-receptor concentration (B) VLDL secretion
(c) Mevalonic acid formation (D) Co-enzyme A formation
Ans.C
Q.63 Which 1 of the subsequent drugs is withdrawn from the market due to torsade de pointes?
(A) Chlorpromazine (B) Astemizole
(C) Haloperidol (D) Domperidone
Ans.B
Q.64 Ganciclovir is mainly used for the treatment of infection caused by
(A) Cytomegalovirus (B) Candida albicans
(C) Herpes zoster virus (D) Hepatitis B virus
Ans.A & C
Q.65 Identify the 1 rational combination which has clinical benefit :
(A) Norfloxacin -Metronidazole (B) Alprazolam -Paracetamol
(C) Cisapride –Omeprazole (D)Amoxycillin -Clavulanic acid
Ans.D
Q.66 Stevens Johnson sjmdrome is the most common adverse effect associated with 1 of the subsequent category
of drugs :
(A) Sulphonamides (B) Macrolides
(C) Penicillins (D) Tetracyclines
Ans.A
Q.67 Amitryptyline is synthesized from the subsequent starting material :
(A) Phthalic anhydride (B) Terephthalic acid
(C) Phthalamic acid (D) Phthalimide
Ans.B
Q.68 The common structural feature amongst the 3 categories of anticonvulsant drugs barbiturates,
succinimides and hydantoins is
(A) ureide (B) imidazolidinone
(C) dihydropyrimidine (D) tetrahydropyrimidine
Ans.A
Q.69 Nicotinic action of acetylcholine is blocked by the drug
(A) Atropine (B) Carvedilol
(C) Neostigmine (D) d-Tubocurarine
Ans.D
Q.70 Chemical nomenclature of procaine is
(A) 2-Diethylaminoethyl 4-aminobenzoate
(B) N,N-Diethyl 4-aminobenzoate
(C) 4-Aminobenzamidoethyl amine
(D) 4-Amino-2-diethylaminoethyl benzoate
Ans.A & D
Q.71 Barbiturates with substitutionat the subsequent position possess acceptable hypnotic
activity :
(A) 1,3-Disubstitution (B) 5,5-Disubstitution
(C) 1,5-Disubstitution (D) 3,3-Disubstitution
Ans.B
Q.72 Selective serotonin reuptake inhibitor is
(A) Imipramine (B) Iproniazide (C) Fluoxetin (D)Naphazoline
Ans.C
Q.73 Proton pump inhibitors like omeprazole and lansoprazole contain the subsequent ring
system :
(A) Pyrimidine (B)Benzimidazole (C) Benzothiazole (D) Oxindole
Ans.B
Q.74 A metabolite found from Aspergillus terreus that can bind very tightly to HMG CoA reductase enzyme is
(A) Fluvastatin (B) Cerivastatin (C) Lovastatin (D) Somatostatin
Ans.C
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Q.75 Cyclophosphamide as anticancer agent acts as
(A) alkylating agent before metabolism (B)alkylating agent after metabolism
(C) phosphorylating agent after metabolism (D) DNA intercalating agent
Ans.B
Q.76 Artemisinin contains the subsequent group in its structure :
(A) an endoperoxide (B) an exoperoxide
(C) an epoxide (D) an acid hydrazide
Ans.A
Q.77 Indicate the HPLC detector that is most sensitive to change in temperature :
(A) PDA detector (B) Refractive Index detector
(C) Electrochemical detector (D) Fluorescence detector
Ans. B
Q.78 1 of the subsequent statements is NOT actual :
(A) Accuracy expresses the correctness of measurement
(B) Precision represents reproducibility of measurement
(C) High degree of precision implies high degree of accuracy also
(D) High degree of accuracy implies high degree of precesion also
Ans.C
Q.79 In thiazides subsequent substituent is essential for diuretic activity :
(A) Chloro group at position six (B) Methyl group at position 2
(C) Sulphamoyl group at position seven (D) Hydrophobic group at position 3
Ans.C
Q.80 Streptomycin can NOT be provided orally for treatment of tuberculosis because
(A) it gets degraded in the GIT (B) it causes severe diarrhoea
(C) it causes metallic tastein the mouth (D) it is not absorbed from the GIT
Ans.D
Q.81 In organic molecules, fluorescence seldom outcomes from absorption of UV radiation of wavelengths lower
than
(A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm
Ans.A
Q.82 Glass transition temperature is detected through
(A) X-Ray diffractometery (B) Solution calorimetery
(C) Differential scanning calorimetery (D) Thermogravimetric analysis
Ans.C

Q.83 In Gas-Liquid Chromatography, a few of the samples need to be derivatized in order to increase their
(A) volatility (B) solubility
(C)thermal conductivity (D) polarizability
Ans.D

Q.84 Oxidative phosphorylation involves
(A) Electron transport system
(B) Substrate level phosphorylation
(C) Reaction catalyzed by succinic thiokinase in TCA cycle
(D) None of the above
Ans.A

Q.85 Coulter counter is used in determination of
(A) particle surface area (B) particle size
(C) particle quantity (D)all of A, B, C
Ans.D

Q.86 Drugs subsequent 1 compartment open model pharmacokinetics eliminate
(A) bi-exponentially (B) tri-exponentially
(C) non-exponentially (D) mono-exponentially
Ans.D

Q.87 The temperature condition for storage of drug products under cold temperature is provided as :
(A) temperature ranging from 8°C and 25°C (B) temperature beneath 20C
(C) temperature at 0°C (D) temperature ranging from 2cCand S:
C
Ans.D
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Q.88 Many xenobiotics are oxidized by cytochrome P450 in order to
(A) increase their biological activity
(B) increase their disposition in lipophilic compartments of the body
(C) increase their aqueous solubility
(D) all of the above
Ans.D

Q.89 The subsequent protein/polypeptide has a quaternary structure :
(A) cc-Chymotrypsin (B) Hemoglobin
(C) Insulin (D) Myoglobin
Ans.B
Q.90 Drugs in suspensions and semi-solid formulations always degrade by
(A) 1st order kinetics (B)second order kinetics
(C) zero order kinetics (D) non-linear kinetics
Ans.

Q.91 In nail polish, subsequent polymer is used as a film-former :
(A) Nitrocellulose (B) Polylactic acid
(C) Hydroxypropyl methylcellulose (D) Cellulose acetate phthalate
Ans.A
Q.92 Rabies vaccine (living) is prepared using
(A) Sheep blood (B) Mice lymph
(C) Horse plasma (D) Fertile eggs
Ans.
Q.93 A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of
100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is :
(A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Ans.C

Q.94 Geriatric population shouldbe included in the subsequent Phase of clinical trials
(A) Phase I (B) Phase II (C) Phase III (D) Phase IV
Ans.C
Q.95 Class 100 area is referred to
(A) Manufacturing area (B) Aseptic area
(C) Clean room (D) Ware house
Ans.B
Q.96 How many mL of a 1:500 w/v stock solution should be used to make five liters of 1:2000 w/v solution?
(A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL
Ans.C
Q.97 The Volumeof distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL
instantaneous concentration in plasma shall be
(A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L
Ans.A

Q.98 It is needed to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half
life of 1.386 hr and Vd of five L. The dose needed in a sustained release product will be
(A) 600 mg (B) 300 mg 30 mg (D) 60 mg
Ans.
Q.99 Which 1 of the subsequent is NOT an ex-officio member of Pharmacy Council of India?
(A) The Director General of Health Services
(B) The Director of Central Drugs Laboratory
(C) The Drugs Controller General of India
(D) The Director of Pharmacopoeia Laboratory
Ans.D

Q.100 In which of the subsequent techniques the sample is kept beneath triple point?
(A) Lyophilization (B) Spray drying
(C) Spray congealing (D) Centrifugation
Ans.A

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