Andhra University 2006 M.Sc Microbiology - Question Paper

[SMB-S-303]

M.Sc. DEGREE exam

3rd Semester

Microbiology

BIOSTATISTICS AND BIOINFORMATICS

(Revised regulatons effective from 2005-2006 admitted batch)

Time: 3 hours Maximum:85 marks

1. Write short notes on any 5 of the following:
(5*5=25)

(a) Correlation coefficient
(b) Type-I and Type-II errors
(c) Similarity measures
(d) BLAST
(e) Phylogenetic trees
(f) Fragment assembly
(g) Transmembrane segments
(h) Homology

UNIT-I

2.
(a) discuss the properties of normal distribution and its applications in biology. . (15)

Or
(b) How do you perform student`s t-test for paired samples?


UNIT-II

3.
(a) What is Euclidean distance? How it is used as a likeness measure?

Or (15)

(b) Write about pairwise sequence alignment

UNIT-III

4.
(a)What is branch and bound method? How does it help in the consruction of a phylogenetic tree? (15)

Or

(b) What is peptide sequencing? How is it done with spectroscopic data?


UNIT-IV

5.
(a) What is a 3D protein structure? How is it predicted? (15)

Or

(b) discuss neural network as a tool in predicting secondary structure.

Earning:   Approval pending.