Veer Narmad South Gujarat University 2011-3rd Year B.Pharm SB-1163A_B PH - 303 : Medicinal chemistry - 1 : - 2 a - Question Paper
SB-1163-A_B
- II
Year B. Pharm. Examination
March / April - 2011
Medicinal Chemistry - I : Paper
|
Time : 3 Hours] Instruction : 6silq<3i Puunkiufl SnwiA u* qsq <KH=fl. Fillup strictly the details of signs on your answer book. Name of the Examination : |
[Total Marks : 70 "x Seat No.: |
T. Y. B. PHARM.
Name of the Subject:
PH-303 : MEDICINAL CHEMISTRY -1 : PAPER - 2
Student's Signature
|
-Subject Code No. |
|
-Section No. (1,2......): 1&2 |
SECTION I
1 Draw the structure of following drugs and give their 12 chemical name : (any six)
|
(a) |
Pyrazinamide |
|
(b) |
Isoprenaline |
|
(c) |
Penicillin V |
|
(d) |
Dapsone |
|
(e) |
Primaquine |
|
(f) |
Triprolidine |
|
(g) |
Cemitidine |
|
00 |
Ciprofloxacin |
2 Answer the following (any three) 12
(a) Classify parasympatholytic agents and explain one example from each class.
(b) Classify antineoplastic agent and give example with structure for each class.
(c) Classify antifun gal agents and describe drugs interfering with metabolic processes.
(d) Enlist eicosanoids and describe chemistry of prostaglandins.
(e) Describe drugs acting on different stages of malarial life cycle.
3 Answer the following (any two) 11
(a) Give the chemistry and SAR of tetracycline.
(b) Enlist different physiochemical parameters used in QSAR explaining parameters from each class and highlight their importance in drug discovery process.
(c) Describe different steps involved in viral replication with drugs acting on each stage of replication process.
SECTION II
4 Name the ring system present in the structure and 10
mechanism of action of following drugs (any five)
|
(a) |
Isoniazid |
|
(b) |
Fluconazole |
|
(c) |
Methotrexate |
|
(d) |
Quinine |
|
(e) |
Ampicillin |
|
(f) |
Promethazine |
|
(g) |
Zidovudine |
5 Answer the following (any four) 10
(a) Write the SAR of Cholinomimetic drugs.
(b) Classify Quinolones and describe the mechanism of action of it.
SB-1163-A_B] 2 [ Contd....
(c) Classify Anti-ulcer agents and explain one example from each class.
(d) Explain the chemistry of Penicillin.
(e) Classify antitubercular drugs and explain second line agents.
(f) Describe the SAR of H2 receptor antagonistic drugs.
6 Outline the synthesis and give IUPAC name of the 15
following : (any five)
|
(a) |
Sulphamethoxazole |
|
(b) |
Chloramphenicol |
|
(c) |
Omeprazole |
|
(d) |
Dicyclomine |
|
(e) |
Pyridostigmine |
|
(f) |
Chloroquine |
|
(g) |
Ethambutol. |
SB-1163-A_B] 3 [ 600 ]
|
Attachment: |
| Earning: Approval pending. |
