Veer Narmad South Gujarat University 2011-4th Year B.Pharm SB-1173 PH- 403 Medicine Chemistry - 2 a - Question Paper
Final Year B. Pharm. Examination
March / April - 2011
PH - 403 : Medicinal Chemistry - II
SB-1173
Time : 3 Hours] [Total Marks : 70
Instructions :
Seat No.:
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Fillup strictly the details of signs on your answer book.
Name of the Examination :
Final Year B. Pharm.
Name of the Subject:
PH - 403 : Medicinal Chemistry - 2
Student's Signature
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-Subject Code No.: |
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-Section No. (1,2,.....): 1&2 |
(2) Attempt and tie each section in separate answer books.
(3) Each section carries 35 marks.
1 (a) Give name and structure of a drug with following 5
characteristics (any five)
(i) Liquid sedative
(ii) Neuroleptics antihypertensive
(iii) Oral anabolic steroid
(iv) Analeptic
(v) a2 stimulant antihypertensive
(vi) Narcotic antagonist
(vii) Used in hypertensive crisis.
(b) Give structure and chemical name of following 6
drugs : (any six)
(i) Meprobamate
(ii) Phenylbutazone
(iii) Caffiene
(iv) Allopurinol
(v) Probenecid
(vi) Prochlorperazine
(vii) Chlorthalidone
(viii) Acetazolamide.
2 Attempt any three questions : 12
(a) Discuss structural features of thyroid hormones with respect to their activity.
(b) What are neuroleptics ? Write their mechanism classifying them.
(c) Explain how structures of all opioids closely resemble each other discussing their activity.
(d) How do general and local anesthesias differ from each other ? Classify local anesthetics with structures.
(e) What are ovulation inducers ? Write in brief about estrogens.
3 Attempt any two questions : 12
(a) Describe giving examples oxidative reactions of drug metabolism involving C-0 and C-S systems.
(b) Describe reductive type reactions of drug metabolism giving examples.
(c) Classify diuretics giving mechanism of action and also give structures from each class.
4 Write synthesis of following : (any five) 10
(a) Methadone
(b) Diclofenac
(c) Carbamazepine
(d) Haloperidol
(e) Hydralazine
(f) Guanethidine
(g) Hydrochlorthiazide.
5 Write short notes on : (any five) 15
(a) CNS stimulants
(b) Insulin
(c) Glucocorticoids
(d) Coronary Vasodilators
(e) Peptidomimetics and nucletidomimetics
(f) Vitamins A and C
(g) Coloring and flavouring agents.
6 Attempt any two questions : 10
(a) Discuss application of prodrugs in drug targetting
(b) Discuss SAR and phenothiazines
(c) Discuss SAR of benzothiadiazines.
SB-1173] 2 [ 400 ]
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Attachment: |
| Earning: Approval pending. |
