Veer Narmad South Gujarat University 2011-4th Year B.Pharm SB-1174 PH- 404 Pharmaceutical Analysis - 2 a - Question Paper
SB-1174
Fourth Year B. Pharm Examination March / April - 2011 PH 404 : Pharmaceutical Analysis II
(Instrumental & Quality Assurance)
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Time : Hours] Instructions : 6silq<3i Puunkiufl [qaim SuwiA u* qsq <KH=fl. Fillup strictly the details of signs on your answer book. Name of the Examination : |
[Total Marks : 70 N Seat No.: |
FOURTH YEAR B. PHARM
Name of the Subject:
PH 404 : PHARMACEUTICAL ANALYSIS II
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-Subject Code No.: |
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-Section No. (1,2......): Nil |
SECTION - I
1 (a) Differentiate between : (any two) 4
(i) Isocrantic and Gradient elution.
(ii) Molecular ion peak and Base peak in MS
(iii) Absorbance and Absorptivity.
(b) Attempt any three of the following : 6
(i) What is the role of Quality circles in successful implementation of TQM in business organizations ?
(ii) Why specificity is considered as a vital validation parameter for identification tests ?
(iii) Convert the following absorbance data to transmittance and % transmittance :
(a) 0.059
(b) 0.321
(iv) Calculate % -max of o-bromo benzaldehyde and p-amino benzoic acid by Woodward Fieser rule.
2 Attempt any four of the following : 16
(i) Explain principle of RIA. State its applications.
(ii) Enlist the factors influencing vibrational frequencies in Infrared Spectrophotometry and explain any two.
(iii) Discuss applications of DTA and DSC.
(iv) Explain with a labelled diagram the working of Dropping Mercury Electrode (DME).
(v) Explain the principle of Ion exchange chromatography. Which ion exchanger (SP) would you use for a strongly basic analyte ? What mobile phase pH range would result in its (i) capture/retention (ii) release/elution ?
(vi) Explain McLafferty rearrangement and Ring rule in Mass Spectrometry.
3 Answer any three of the followings : 9
(i) What are the advantages of 13C NMR over XH NMR ?
(ii) Explain the principle of flame photometry and state its limitations.
(iii) Give the characteristic absorption bands in the IR spectra of benzyl alcohol..
(iv) Explain the following terms in Affinity chromatography : Spacer arm, Ligand, Matrix.
(v) Explain working of Katharometer with a labelled diagram.
SECTION - II
4 Explain the following terms : (any eleven) 11
(i) Wavenumber
(ii) Auxochrome
(iii) Quenching
(iv) Stokes shift
(v) Forbidden transition
(vi) Robustness
(vii) Range
(viii) Specific rotation
(ix) Quality control
(x) LOQ
(xi) Laser ablation
(xii) Atomization
(xiii) Indicator electrode
(xiv) SOP
(xv) Monochromator.
5 Attempt any three of followings : 12
(i) What is Plasma ? Explain working of Direct current plasma source with a labelled diagram.
(ii) Draw and explain Jablonski diagram.
(iii) Discuss the factors affecting the current-voltage curves in polarography with the help of Ilkovic equation.
(iv) Discuss the prominent peaks in the mass spectrum of 1-butanol and 2-butanol.
(v) How many signals would you expect in the NMR spectrum of following compounds ?
(a) 1-propyl bromide
(b) a-bromo butanoic acid
(c) 2,3-dibromopropene
(d) p-anisidine
6 Answer any two of the followings : 12
(i) What is chemical shift ? Discuss the factors affecting chemical shift with suitable examples.
(ii) What is column efficiency ? What do you mean by zone broadening ? Discuss the kinetic variables affecting one broadening.
(iii) Explain the theory of IR absorption spectrometry and discuss types of molecular vibrations.
SB-1174] 3 [ 600 ]
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Attachment: |
| Earning: Approval pending. |
