University of Pune 2010 B.Pharm 1.1 : PHARMACEUTICS – I (2008 Pattern) - Question Paper

[3856] – 101
First Year B. Pharmacy Examination, 2010
1.1 : PHARMACEUTICS – I (2008 Pattern)
Time : three Hours Max. Marks : 80
Instructions. :
i) Answers to the 2 parts should be written in separate books.
ii) Neat diagrams must be drawn wherever necessary.

part – I
1. Attempt any 1 : 10
explain in detail concept of physicochemical properties involved in preformulation.
OR
discuss the concept of drug delivery system. Add a note on sustained and targeted drug delivery.

2. Attempt any 5 : 15
a) define Ayurveda as system of medicine.
b) describe 'New Drug' and 'Drug' as per D and C Act, 1940.
c) discuss cGMP as a tool for quality assurance.
d) define the development of pharmaceutical industry in India.
e) describe bioequivalence, biopharmaceutics and bioavailability.
f) discuss ideal characteristics of packaging material.
g) discuss the need of dosage forms.

3. Write short notes (Any three) : 15
a) Mechanism of Absorption.
b) Quality control of radiopharmaceuticals.
c) Good manufacturing practices.
d) Containers and closures
e) Dose efficiency and dose response concept.

part – II
1. Solve any 1 : 10
elaborate solutions ? discuss methods of preparation of solutions and factors affecting rate of solution.
OR
What is filtration ? discuss in brief filter aids and filter media. discuss the construction, working and application of filter leaf.

2. Solve any 5 : 15
a) describe elixir, linctus and syrup. provide their examples.
b) discuss manufacturing of effervescent granules.
c) describe size separation. Write standards for powders as per I.P.
d) discuss the different mechanisms for mixing of liquid.
e) What do you mean by viscosity ? explain any 1 method for viscosity determination.
f) Write a note on Dry Syrup.
g) explain different factors affecting size reduction.

3. Solve any three. 15
a) discuss construction, working and application of Edge and End runner mill.
b) explain the formulation and valuation of oral rehydration powder.
c) define in brief different methods for size separation
d) Write a note on :
i) Propeller mixer
ii) Hammer Mill
e) describe Syrup. discuss methods of preparation and preservation of syrups.

Earning:   Approval pending.