University of Pune 2010 B.Pharm Pharmaceutical Chemistry V (Medicinal) (2004 – ) - Question Paper

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Fourth Year B.Pharmacy Examination, 2010
Pharmaceutical Chemistry V (Medicinal) (2004 – Course)
Time : three Hours Max. Marks : 80
Note :
1) Q.No. one and Q.No. five are compulsory. Out of remaining attempt 2 ques. from part I and 2 ques. from part II.
2) ans to the 2 parts should be written in separate ans books.
3) Figures to the right indicate full marks.
4) accurate structure must be drawn wherever necessary.

part – I
1. Classify CNS depressants and add a note on SAR, MOA of benzodizepins. 12

2.
a) elaborate major pathways of metabolism ? discuss phase II reactions using suitable examples. 6
b) discuss adrenergic receptors and add a note on one -selective blockers. 6
c) Draw synthesis of atenolol. 2

3.
a) Classify general anasthetics and add a note on SAR of barbiturates. 6
b) Write a note on MAO inhibitors. 6
c) Draw synthesis of Phenytoin. 2

4.
a) Write notes on (any three) : 12
1) Drug receptor interactions.
2) Oxazolidinediones as anticonvulsants.
3) Drugs used in Alzeimers disease.
4) Long acting neuroleptics.
b) elaborate various factors affecting the metabolism ? 2

part – II
5. Classify NSAIDs in detail and write SAR, MOA of salicylates. 12

6.
a) Classify antianginal agents and add a note on calcium channel blockers. 6
b) elaborate thiazide diuretics ? discuss in detail. 6
c) Draw synthesis of diclofenac. 2

7.
a) elaborate opioid analgesics ? Write SAR and MOA of Morphine. 6
b) Write a note on non steroidal estrogenic agents. 6
c) Draw synthesis of omeprazole. 2

8.
a) Write notes on (any three) : 12
1) ACE inhibitors
2) Amide based local anesthetics
3) H2 Blockers
4) Class IA antiarrythmic drugs.
b) Draw synthesis of Chorpheniramine or Benzocaine. 2

Earning:   Approval pending.