University of Pune 2010 B.Pharm 2.1 : Physical Pharmacy (2008 Pattern) - Question Paper

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Second Year B.Pharmacy Examination, 2010
2.1 : PHYSICAL PHARMACY (2008 Pattern)
Time : three Hours Max. Marks : 80
Instructions:
1) Answers to the 2 parts should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All ques. are compulsory.

part – I
1. Attempt any 1 : 10
discuss the DLVO theory and its pharmaceutical application. Highlight the stability of a lyophobic sol.
OR
What is critical constant ? discuss the various methods of liquefaction of gases.

2. Attempt any 5 (3 marks each) : 15
i) discuss the various binding forces ranging from molecules.
ii) Derive Gibbs phase rule.
iii) describe glass transition temperature.
iv) elaborate ideal and real solutions ?
v) explain solubility of weak electrolytes.
vi) Enlist applications of colloids.
vii) describe legal regulations of corresponding state.

3. Write short notes on any 3 (5 marks each) : 15
i) two component system.
ii) Protective colloids.
iii) Debye Huckel theory.
iv) Solute solvent interaction.
v) Van der Waals formula for real gases.

part – II
4. Attempt any 1 : 10
Classify rheological systems along with examples. Add note on Cupe and Bob viscometer.
OR
discuss the various methods for the determination of order of a reaction.

5. Attempt any 5 (3 marks each) : 15
i) describe rate determining step, order of reaction and molecularity of reaction.
ii) elaborate surfactants ?
iii) Flow properties of powders and factors affecting it.
iv) describe and distinguish dissolution and diffusion.
v) discuss Nernst potential.
vi) Enlist applications of rheology.
vii) explain apparent zero order reaction.

6. Write short notes on any 3 (5 marks each) : 15
i) Methods for determining surface area.
ii) USP dissolution test.
iii) Sedimentation method of analyzing the particle size.
iv) Soluble monolayer and Gibbs formula.
v) Effect of temeperature on rate on reaction.

Earning:   Approval pending.