University of Pune 2010 B.Pharm 2.2 : Pharmaceutical Microbiology And Immunology (2008 ) - Question Paper

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Second Year B.Pharmacy Examination, 2010
2.2 : PHARMACEUTICAL MICROBIOLOGY AND IMMUNOLOGY (2008 Course)
Time : three Hours Max. Marks : 80
Instructions:
1) ques. Nos. one and five are compuslroy. OUt of the remaining attempt two ques. from part I and two ques. from part II.
2) Answers to the 2 parts should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right inidcate full marks.

part – I
1. ans the subsequent (any five) : 10
a) Write name and function of oil used for oil-immersion objective.
b) Write note on 'Protozoa'.
c) Differentiate ranging from Slime layer and Capsule.
d) provide the general properties of viruses,.
e) discuss inshort 'Bacterial reproduction'.
f) Write the contributions of Louis Pasteur for microbiology.

2.
a) define in detail different methods used for measurement of bacterial growth. 8
b) discuss in detail principal and working of compound microscope. 7

3. ans the subsequent : 15
a) elaborate dermatophytes ? discuss it.
b) COmment on 'Actinomycetes as source of antibiotics'.
c) discuss the various factors affecting the microbial spoilage of pharmaceutical
products.

4. Write short notes (any three) : 15
a) Colony characteristics.
b) HIV.
c) Rickettsia.
d) Preservative efficacy test.

part – II
5. ans the subsequent : 10
a) describe :
i) Immunogen b) Z-value
b) provide the disadvantges of phenol coefficient test.
c) What is the selection criteria for test micro-organisms used for microbial assay of vitamin ?
d) Write the biological effects of lymphokines released by T cells.
e) provide the Harmful role of normal microbial flora of the human body.
f) elaborate allergenic extracts ? discuss it.

6.
a) discuss in detail nonspecific defence mechanism of human host against pathogens. 8
b) elaborate various methods of sterillization ? Descirb in detail sterillization by filtration. 7

7. ans the subsequent : 15
a) discuss in brief quality control of vaccine.
b) define in detail Type-I hypersensitivity.
c) discuss the principal and procedure of ELIISA.

8. Write a note on (any three) : 15
a) Designing of aspetic area.
b) MIC.
c) Immunoglobulins.
d) Factors affecting on disinfectant action

Earning:   Approval pending.