University of Pune 2010 B.Pharm 2.5 : Pharmaceutical Analysis – I - Question Paper

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Second Year B.Pharmacy Examination, 2010(2004 Course)
2.5 : PHARMACEUTICAL ANALYSIS – I
Time : three Hours Max. Marks : 80
Instructions:
1) Q. Nos. one and five are compulsory. Out of the remaining, attempt any two ques. from part I and two ques. from part II.
2) Answers to the two parts should be written in separate ans books.
3) Black figures to the right indicate full marks.

part – I
1.
a) Why glacial acetic acid is used as solvent and Perchloric acid in glacial acetic acid is used as titrant in determination of very weak bases ? 6
b) discuss with example, the determination of very weak acid by nonaqueous titration. 6

2.
a) discuss the Indicator theories of neutralization indicators. 10
b) How 0.1 M hydrochloric acid is prepared and standardized ? 4

3.
a) discuss the titration curve for titration of strong acid with strong base. 7
b) What is sampling ? discuss the sampling techniques. 7

4.
a) What is primary standard ? Enlist ideal properties of primary standard. 6
b) discuss the principle involved in and method of determination of aspirin by titrimetric analysis.

part – II

5.
a) State various kinds of EDTA titrations with suitable examples. 8
b) How will you prepare and standardize 0.01 M disodium EDTA solution ? 4

6.
a) explain methods of endpoint detection in precipitation titrations. 8
b) Classify errors in pharmaceutical analysis. 6

7.
a) provide a detailed account of Kjeldahl's method. 8
b) compare co-precipitation and post-precipitation. 6

8. Write notes on (any two) : 14
a) Good Laboratory Practices
b) t test
c) Metallochromic indicators

Earning:   Approval pending.