University of Pune 2010 B.Pharm Pharmaceutics– V(Biopharmaceutics and Pharmacokinetics)(2004 ) - Question Paper

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Fourth Year B. Pharm. Examination, 2010
Pharmaceutics– V(Biopharmaceutics and Pharmacokinetics)(2004 Course)
Time : three Hours Max. Marks : 80
Instructions:
1) ques. Nos. one and five are compulsory. Out of the remaining attempt two ques. from part I and two ques. from part II.
2) Answers to the 2 parts should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.

part – I
1.
a) explain the physicochemical factors affecting drug absorption. Highlight diffusion layer model/film theory. 7
b) What is the influence of drug pka and GI pH on drug absorption ? 3

2.
a) How the organ size and perfusion rate influence the drug distribution ? 7.5
b) discuss the various physiological barriers to the drug distribution. 7.5

3.
a) How can the principle of binding be used for drug targetting ? discuss. 7.5
b) What is the influence of different disease states on plasma protein level and drug binding ? 7.5

4.
a) Write a note on BCS and BDDCS. 15
b) explain bioactivation and tissue toxicity.[3856] – 44 

part – II
5. discuss the factors influencing renal excretion of drug. 10

6.
a) discuss the various mechanism of drug interactions. 10
b) Quote examples of beneficial drug interactions. 5

7. elaborate pharmacokinetic models ? What is the importance and utility of developing such models ? explain briefly the kinds of pharmacokinetic models. 15

8.
a) What is flip-flop phenomenon ? 7.5
b) explain the kinds of physiological models. 7.5

Earning:   Approval pending.