University of Pune 2010 B.Pharm 2.7 : Pharmacology – I (2008 ) - Question Paper

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Second Year B.Pharmacy Examination, 2010
2.7 : Pharmacology – I (2008 Course)
Time : three Hours Max. Marks : 80
Note :
1) All ques. are compulsory.
2) Answers to the 2 parts should be written in separate ans books.
3) Neat labelled diagrams must be drawn wherever necessary.
4) Black figure to the right indicate full marks.

part – I
1. describe and classify anticoagulants. explain in detail pharmacology of oral anti-coagulants. 10
OR
1. explain the anaphylaxis and allergic reactions mediated by histamine and provide its treatment.

2. Solve any 5 of the subsequent : 15
i) Enlist the different processes which determine the renal excretion of drugs and explain in detail tubular secretion.
ii) Enlist the different factors affecting the renal excretion of drugs. How pH and pKa of drugs can affect the renal excretion ?
iii) explain about photosensitivity.
iv)Discuss in detail passive diffusion.
v)Discuss in detail ligand gated ion channels.
vi)Discuss how genetic factors modifies drug action.
vii)Discuss the pharmacology of prostaglandins.

3. Write a note on the subsequent (any three) : 15
i) Essential drug concept and orphan drugs
ii) Transmucosal routes
iii) Redistribution and Tissue storage
iv) Dose response relationship
v) Non viral vectors for gene transfer.

part – II
4. explain the pathogenesis and clinical features of kind one and two diabetes mellitus. Add a note on acute metabolic complications of diabetes mellitus. 10
OR
4. describe hypertension. Write the general and etiologic classification of hypertension. explain the etiology and pathogenesis of essential hypertension.

5. Solve any 5 of the subsequent : 15
i) explain the pathophysiology of inflammation.
ii) explain the etiology of chronic peptic ulcers.
iii) explain the etiology and kinds of HF.
iv) describe tuberculosis and explain the kinds of tuberculosis.
v) Pathophysiology of gonorrhea.
vi) explain the etiology of chronic obstructive airway disease.
vii) explain the etiology of malignancy.

6. Write a note on the subsequent (any three) : 15
i) Lepromatous leprosy
ii) Alzheimer's
iii) Parkinson's disease
iv) Urinary tract infections
v) Cardiac arrhythmias.


Earning:   Approval pending.