University of Pune 2011 B.Pharm BPharmacy Human Anatomy And Physiology - Question Paper
B. Pharmacy exam Human Anatomy And Physiology [3956] - 105
First Year B. Pharmacy Examination, 2011 (2008 Pattern) 1.5 : HUMAN ANATOMY AND PHYSIOLOGY
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION - I
1. Draw a neat labelled diagram of conduction system of heart. Explain in detail
cardiac cycle. 10
OR
1. Draw a neat labelled diagram of human respiratory system. Explain in detail transport of O2 and CO2 during respiration. 10
2. Solve any three : 15
i) Explain mechanism of blood clotting.
ii) Draw a neat labelled diagram of cell and explain movement of materials across plasma membrane.
iii) Explain structure and functions of lymph node.
iv) Enlist organs involved in digestive system and give functions of each organ.
v) Explain in detail structure and functions of epithelial tissue.
3. Write short notes on (any five) : 15
i) Nervous tissue
ii) Platelet plug formation
iii) Blood pressure
iv) Spleen
v) Mechanism of respiration
vi) ECG
vii) Functions of liver.
SECTION - II
4. Explain in detail physiology of urine formation.
10
10
15
OR
4 . Classify nervous system and explain in detail sympathetic and parasympathetic
nervous system.
5. Solve any three :
i) Explain the physiological role of hormones of anterior pituitary gland.
ii) Draw a neat labelled diagram of nephron and explain structure of nephron.
iii) Explain menstrual cycle.
iv) Describe components of external, middle and internal ear.
v) Explain physiology of muscle contraction.
6. Write short notes on (any five) : 15
i) Renin angiotensin aldosterone system
ii) Reflex arc
iii) Interior of eye ball
iv) Functions of skin
v) Cerebrum
vi) Spermatogenesis
vii) Cranial nerves.
Fourth Year B.Pharm. Examination, 2011 PHARMACOLOGY - III (Including Clinical) (2004 Course)
Time : 3 Hours Max. Marks : 80
Instructions :1) Question No. 1 and 5 are compulsory. Out of the remaining attempt any two questions from Section I and two questions from Section II.
2) Answers to the two sections should be written in separate book.
3) Figures to the right indicate full marks.
SECTION - I
1. Classify antihypertensive agents. Write in detail pharmacology of any one calcium channel antagonists. 12
2. Write in detail pharmacological classifications of penicillines. Explain in detail pharmacology of antipseudomonal penicilline. 14
3. Classify and differentiate anti retroviral and non-anti retroviral agents. Explain in detail general principles of anti retroviral therapy. Write in detail pharmacology of any one antinucleoside reverse transcriptase inhibitors. 14
4. Write a note on any two : 14
A) Goals of treatment of heart failure.
B) Indications for the clinical use of combinations of antimicrobial agents.
C) Platinum coordination complexes.
SECTION - II
5. Classify bioassays. Explain in detail rational approaches, design, indications and limitations of bioassays. Write in detail bioassay of digitalis. 12
6. What are the ethical and regulatory issues as per GCP in clinical trials. Explain in detail phase-IV clinical study. 14
7. A) Discuss the role of drug information services, its types and importance. 14 B) Explain the features of good clinical practices in clinical trials.
8. Write a note on any two : 14
A) Approaches in enhancement of elimination of the poisons.
B) Observational records in clinical pharmacology.
C) Treatment of iron poisoning.
B/I/11/3505
First Year B. Pharmacy Examination, 2011 1.1 : PHARMACEUTICS - I (2008 Pattern)
Illlllllllllllllllllllll
Time : 3 Hours Max. Marks : 80
Instructions: Answer to the two Sections should be written in separate books. Neat diagrams must be drawn wherever necessary.
SECTION - I
1. Attempt any one : 10
Define bioavailability and bioequivalence. Discuss absorption and mechanism of absorption.
OR
Discuss in detail concept of physicochemical properties involved in preformulation.
2. Attempt any five : 15
a) What is pharmacopoeia ? Add a note on national formulary.
b) Explain ideal characteristics of packaging material.
c) Mention application of radio pharmaceuticals.
d) Describe Homoeopathy as system of medicine.
e) Give schematic representation of development of new drug.
f) Define dosage form and give its importance.
g) Explain CGMP as a tool for quality assurance.
3. Write short notes (any three) : 15
a) Phases of clinical trials
b) Development of pharmaceutical industry
c) Drug metabolism
d) Container and closure
e) Sustained release and targeted drug delivery.
1. Solve any one :
What is size reduction ? What are factors that affect size reduction ? Explain in detail principle, construction, working and pharmaceutical application of Ball
mill.
OR
What are solutions ? Explain methods of preparation of solutions and factors affecting rate of solution.
2. Solve any five :
15
a) What are syrups ? How invert syrup is prepared and stored ?
b) Draw well labelled diagram of rotary drum filter.
c) Define size separation. Write on standards for powders as per I.P.
d) Explain various filter medias used for filtration.
e) Write a note on mouthwashes.
f) Define viscosity. Explain how determination of viscosity is important in formulation of solution.
g) Write a note on pouch filling machine.
3. Solve any three : 15
a) Discuss formulation and evaluation of tooth powder.
b) Discuss methods used for improvement of solubility.
c) What are aromatic waters ? How they are preserved ? Differentiate between aromatic and concentrated aromatic water.
d) Write a note on :
i) Impeller
ii) Dry syrup.
e) Explain construction, working and application of hydro extractors.
First Year B.Pharmacy Examination, 2011 1.2: MODERN DISPENSING PRACTICES (2008 Pattern)
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Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION - I
1. Define posology. Explain factors affecting dose of drug. What will be the dose of child of 3 yrs; if adult dose is 500 mg ? 10
OR
1. Define compounding and dispensing of medication. Discuss steps involved in compounding. Give auxiliary labelling conditions for suspensions, Linctuses and lotions. 10
2. Answer in brief (any five) : (3x5=15)
a) Give the pharmaceutical applications of emulsions.
b) Explain formulation of syrups.
c) Explain physical stability of suspensions.
d) Comment on information to be written on a label.
e) Classify suspensions and emulsions.
f) Describe in brief good dispensing practices.
g) In what proportion should 50% and 90% alcohol mixed so as to make 60% alcohol.
3. Write a short note on (any three) : (5x3=15)
a) Pharmasist as health care provider
b) Parts of prescription
c) Patient counseling for ENT preparations
d) Cracking of emulsions
e) Additives in suspensions.
4. Explain the concept of unit dose drugs, write its merits and demerits. Write
patient counselling for various types of tablets.
OR
4. Write with example medication errors and role of pharmacist in avoiding them. 10
5. Answer any five :
(5x3=15)
a) What do you mean by aseptic processing ?
b) Describe the methods of powder mixing containing special type of drugs.
c) Write the patient counselling points for dispensing of eye ointments.
d) Describe the properties of ligatures and sutures.
e) Describe the water soluble ointment base.
f) Write the legal requirements and forms to obtain FDA license to open retail pharmacy.
g) Write patient counselling for oral contraceptives.
6. Write note on any three : (3x5=15)
a) Dry syrups
b) Vaginal gels
c) Glycero-gelatin suppository base
d) Rational drug use
e) Patient counselling for metered dose inhaler.
First Year B.Pharmacy Examination, 2011 Paper - 1.4 : PHARMACEUTICAL ORGANIC CHEMISTRY - I (2008 Pattern)
Time : 3 Hours Total. Marks : 80
Instructions : 1) All questions are compulsory.
2) Answers to the two Sections should be written in separate books.
3) Black figures to the right indicate full marks.
SECTION - I
1. Explain the mechanism involved in Friedel Craft acylation and Nitration of Benzene. 10
OR
Compare SN1 and SN2 Mechanism.
2. Answer the following (any five) : 15
1) Define and illustrate Tautomerism.
2) Compare the stability of primary, sec. and tertiary carbanion ion.
3) What is Inductive effect and explain it with suitable example.
4) What is difference between nucleophilicity and basicity ?
5) Draw as much resonance structure as you can for following :
a) Aniline
b) Phenol.
6) Explain Huckels rule for aromaticity with suitable example.
7) Draw the structure of following compound :
a) 2-Methyl N-N di-methyl butanamine
b) 4-Amino-3-chloropentanenitrile
c) Cyclopropane carboxylic acid.
3. Answer the following (any three) : 15
1) Write a synthesis of following compound starting with benzene and suitable reagent :
a) meta nitro toluene
b) 1, 3 dinitro benzene.
2) Explain substitution nucleophilic unimolecular reaction mechanism with stereochemistry with suitable examples.
3) What is Hyper conjugation ? Explain with suitable example.
4) Write a note on optical isomerism. Explain it with a suitable example.
5) Define the following terms and give any two suitable examples of each :
a) Activating group
b) Deactivating group
c) Ortho and para director.
SECTION - II
4. A) Explain E-1.E-2 and E-1 (cb) reaction with mechanism. 10
OR
A) Explain why aldehydes are more reactive than ketone for nucleophilic addition reaction and add a note on addition of water to aldehyde and ketone.
5. Answer the following (any five) : 15
1) How will you differentiate the following pair of compounds by simple chemical test ?
a) Pentanal and Pentanone
b) Benzoic acid and alpha-naphthol.
2) Explain hydration reaction with C-C multiple bond.
3) Explain acid catalysed esterification of carboxylic acids.
4) Arrange the following compounds in order of increasing reactivity.
a) Acetamide
b) Acetic anhydride
c) Methyl acetate.
5) Write any three chemical reactions of phenols.
6) Ring substitution reaction of aromatic amines.
7) Give any two methods of synthesis of amines.
6. Write note on (any 3) : 15
1) Preparation of sulphonic acid
2) Canizarros reaction
3) Ozonolysis
4) Aldol condensation
5) Knovengel condensation.
First Year B. Pharmacy Examination, 2011 1.6 : PHARMACEUTICAL ENGINEERING (2008 Pattern)
Time : 3 Hours Max. Marks : 80
Instructions: 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION - I
1. Explain heat transfer to boiling liquids. 10
OR
Describe steps in crystal growth and explain different theories of crystal growth.
2. Answer the following (any five) : 15
a) Thermostatic steam trap.
b) Different methods of feeding evaporator.
c) Use of humidity chart.
d) Sling psychrometer.
e) Wiped film evaporators.
f) Define heat exchangers and describe different types of heat exchangers.
g) Environmental controls in pharmaceutical industry.
3. Write short notes on (any three) : 15
a) Plate Heat exchangers.
b) Draft Tube Battle (DTB) crystallizer.
c) Caking of crystals.
d) Crystal habit.
e) Fouriers law of heat transfer.
4. Describe flow of fluid through packed beds with Poiseullis and Kozenys approach. 10
OR
Define drying. Explain theory of drying with drying curves.
5. Answer the following (any five) : 15
a) Pilot tube.
b) Liquid-liquid extraction and classification of liquid-liquid extractors.
c) Sieve-plate column.
d) Energy losses in fluid flow due to friction.
e) Energy losses in fluid flow due to contraction and enlargement.
f) Freeze dryer.
g) Drum dryer.
6. Write short notes on (any three) : 15
a) Venturi meter
b) Rotocel extractor
c) Podbielniak liquid-liquid extractor
d) Distillation under reduced pressure
e) Height Equivalent to Theoretical Plate (HETP).
Second Year B.Pharmacy Examination, 2011 2.3 : PHARMACEUTICAL BIOCHEMISTRY (2008 Pattern)
Time : 3 Hours Max. Marks : 80
Note : 1) Q. 1 and 5 are compulsory. Out of remaining attempt any two questions from each Section.
2) Draw well labeled diagram wherever necessary
3) Answers to the two Sections should be written in separate books.
4) Figures to right indicate full marks.
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SECTION - I | ||||||||||||||||||||||||
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VI. a) Describe process of transcription and translation. 8
b) Explain gene expression in eukaryotes. 7
VII. a) Describe liver function test in detail. 8
b) Describe cell organelles with their roles. 7
VIII. Write short notes on (any three) : 15
a) Biosensors
b) BMR
c) Marker enzymes
d) Acid-base balance.
B/I/11/ 3,810
Second Year B.Pharmacy Examination, 2011 (2008 Pattern) 2.3 : PHARMACEUTICAL BIOCHEMISTRY (Including Clinical Biochemistry)
Time : 3 Hours Max. Marks : 80
Note : 1) All questions are compulsory.
2) Draw well labeled diagram wherever necessary.
3) Answers to the two Sections should be written in separate books.
4) Figures to right indicate full marks.
SECTION - I
I. a) Classify Enzymes with suitable examples and explain competitive and
non-competitive enzyme inhibition. 10
OR
a) Define and classify lipids with suitable examples. Give their functions in detail.
II. Solve any five from the following : 15
a) Mitochondria
b) Gluconeogenesis
c) a -Helical structure of protein
d) Blood glucose balance
e) Glycogenolysis
f) Co-enzymes and co-factors.
III. Solve any three from the following : 15
a) Explain colour reactions of amino acids
b) TCA cycle
c) Deamination and Transamination
d) Pyrimidine metabolism.
IV. a) Explain DNA recombination technique with its application.
OR
10
15
a) What is BMR ? Describe the factors affecting the BMR in detail.
V. Solve any five from the following :
a) Genetic disorders of carbohydrate metabolism.
b) Write a note on PCR technique.
c) Record keeping in pathology laboratory.
d) Radio immuno assay.
e) Discuss diagnostic application of lactate dehydrogenase.
f) Genetic code.
VI. Solve any three from the following : 15
a) Liver function test.
b) Give biochemical functions of fat soluble vitamins.
c) Acid base balance.
d) Biosensors.
Max. Marks : 80
1) All questions are compulsory.
Time : 3 Hours
Instructions
2) Answer to the two Sections should be written in separate books.
3) Neat diagram must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. a) Assign configuration for the following (any five)
5
|
ii) iv) |  |
|
i) iii) |  |
|
vi) |  |
f-H
v) \\
'4~
b) What are a -amino acids ? Discuss any three methods of synthesis of amino acids. 5
OR
1 . a) What are carbohydrates ? Discuss briefly the open and cyclic structure of
glucose. 5
b) Discuss briefly conformations of cyclohexane using an energy diagram. 5
15
a) What is isoelectric point ? Give its significance.
b) What is dihedral angle in stereisomer and Newman projection formula ?
c) Write a note on Mutarotation.
d) What are distereomers ? Explain with suitable examples.
e) Write in brief conformational analysis of n-Butane.
f) What are polysaccharides ? Discuss in brief about starch.
g) Draw the Fischer projection of following :
i) Meso 2, 3-dibromobutane
ii) 2-Chlorobutane
iii) 2R, 3S-2- Chloroethanol.
3. Answer the following (any three) : 15
a) What are atropisomerism ? Discuss briefly atropisomerism in Biphenyl compounds.
b) Discuss stereo selective and stereo specific reaction with suitable examples.
c) What is racemic resolution ? Explain with suitable examples some important methods used ?
d) What are peptides ? Discuss briefly the primary and secondary structure of peptides.
e) What is combinatorial chemistry ? What are the strategies used for solid supported synthesis ?
SECTION - II
4. a) Write the product of the following reaction.
|
in) |  |
h2o2/koh |
|
iLI | ||
|
CFCOOOH -3-> ? | |
|
v) |  |
iv)
b) What are heterocyclic compounds ? Give the methods of synthesis and
reactions of Furan and isoquinoline. 5
OR
4. What is retro-synthesis ? Write some important rules for disconnection. Give retrosynthesis route of the
i) Ibuprofen
ii) Sulfame thaxazole. 10
5. Answer the following (any five) :
15
a) Give the mechanism of pinacol-pinacolone rearrangement with suitable example.
b) Give the structure and numbering of the following compounds.
i) Isoquinoline
ii) Indole
iii) Imidazole.
c) Explain why pyridine is less reactive than benzene.
d) Why thiophene is more stable, aromatic than pyrrole ?
e) Give the reaction and mechanism of Knorr-pyrrole synthesis.
f) Predict the product
g) Give the synthesis and reactions of hydantoin, pyrimidine.
6. Answer the following (any three) : 15
a) Write in briefly about electrophilic substitution reaction of five membered monoheterocyclic ring system.
b) Discuss the rearrangement with mechanism of Favoroski and Benzilic acid rearrangement.
c) Discuss in brief Bayer-Villiger oxidation.
d) Explain the mechanism of the Skraup synthesis of quinoline.
e) Discuss Fischer-indole synthesis and Bischler-Napieralski synthesis.
Time : 3 Hours Max. Marks : 80
Note : 1) All questions are compulsory.
2) Answers to the two Sections should be written in separate answer books.
3) Neat labeled diagrams must be drawn wherever necessary
4) Black figures to the right indicate marks.
SECTION - I
1. Explain the term biotransformation. Enlist the various reactions involved in the biotransformation of drugs. Explain in detail synthetic reactions. 10
OR
1. Define and classify hypolipidimics. Write the pharmacological actions, therapeutic uses and adverse drug reaction of statins.
2. Solve any five of the following : 15
i) Discuss in detail Side effects.
ii) Discuss about intolerance.
iii) Discuss the drug treatment of pediatrics.
iv) Explain the psychological factor affecting drug action.
v) Explain the mechanism of drug action through enzyme inhibition.
vi) Discuss the redistribution.
vii) Discuss the combined effect of drugs.
3. Write a note on the following (any three) : 15
i) H2 receptor antagonists
ii) Receptor regulation
iii) Warfarin
iv) Carcinogenicity and mutagenicity
v) Applications of gene therapy in various genetic disorders
vi) Advantages and disadvantages of parenteral route.
4. Define peptic ulcers. Explain the etiology and pathogenesis and complications of
acute and chronic peptic ulcers.
10
15
OR
4. Define and classify psychosis. Discuss the pathophysiology of schizophrenia.
5. Solve any five of the following :
i) Discuss the physical carcinogens and radiation carcinogenesis.
ii) Discuss the pathophysiology of acute renal failure.
iii) Define angina pectoris and discuss the types of angina pectoris.
iv) Discuss the pathophysiology of Hepatitis B.
v) Discuss the clinical manifestations of tuberculosis.
vi) Discuss the Etiology of bronchial asthma.
vii) Discuss the pathophysiology of bacillary dysentery.
6. Write a note on the following (any three) : 15
i) Typhoid fever
ii) AIDS
iii) Malaria
iv) Hypersensitivity
v) Epilepsy.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and
2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.
SECTION - I
1. What do you understand by Gene Cloning ? What are various types of cloning vectors involved in the process ? What is the role of expression vectors in recombinant DNA technology. 10
2. A) What is Gel Electrophoresis ? Describe the principle behind the technique
and elaborate on its applications. 8
B) How are animal cell cultures prepared ? Describe in details the composition of the media used in the process. 7
3. A) What are transgenic plants ? How are they developed ? What are their
advantages, explain with suitable examples. 8
B) Write a note on protoplast culture. What are the applications of protoplast
fusion technique ? 7
4. Write notes on any three : 15
a) DNA finger printing
b) Gene sequencing
c) RFLP
d) Gene transfer.
5. How are monoclonal antibodies prepared ? What are their applications in immunotechnology. 10
6. A) Write an elaborate account of manufacturing of Vit B12 via fermentation
technology. Support with neat flow chart. 8
B) Explain the concept of enzyme immobilisation. Comment on its applicability with suitable examples. 7
7. A) Enlist various biotechnologically derived products used in health care
management. Write an elaborate note on Human insulin. 8
B) What are various toxicity studies undertaken in establishing safety and efficacy of biotechnological products. 7
8. Write notes on any three : 15
a) Storage of blood and blood products
b) In-vitro fertilisation
c) Dextran manufacturing
d) ELISA technique.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two questions should be written in separate answer books.
2) Neat diagram must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION - I
1. Explain in detail the principle involved in polarographic technique and explain
its instrumentation. 10
OR
With the help of labeled diagram explain the phenomenon of fluorescence. Discuss the factors affecting fluorescence. 10
2. Attempt any five questions : 15
a) Explain in the principle of atomic absorption spectroscopy.
b) Discuss the factors affecting limiting current.
c) Write the applications of UV-Vis spectroscopy.
d) Discuss the different elution procedures used in column chromatography.
e) Describe the instrumentation of TGA.
f) Explain the following terms :
1) Chromophore
2) Auxochrome
3) Bathochromic shift.
g) Write about selection of solvent system in TLC.
3. Write a note on any three : 15
a) Factors affecting TGA curve
b) Biapmperometric titrations
c) Dropping mercury electrode
d) Applications of Nephelometry and Turbidometry
e) Two dimensional TLC.
SECTION - II
4. Explain Van Deemters equation in detail. How it helps to improve column performance ? 10
OR
Draw a neat labeled diagram of flame photometer. Explain the functioning of each part. Write applications of flame photometry. 10
5. Attempt any five questions : 15
a) Explain the factors affecting DTA curve.
b) Draw a neat labeled diagram of fluorimeter and explain the functioning of each part.
c) Discuss in detail the various types of transitions involved in UV-Vis Spectrophotometry.
d) Describe the applications of DSC.
e) Discuss the various development techniques used in paper chromatography.
f) Explain in brief about Biapmperometric titrations.
g) Write note on partition column chromatography.
6. Write a note on any three : 15
a) HPTLC
b) Spectrophotometric titrations
c) Power compensated DSC
d) Amperostatic Coulometry
e) Electromagnetic spectrum.
Time : 3 Hours Max. Marks : 80
Illlllllllllllllllllll
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory.
SECTION - I
1. Solve any one : 10 Discuss in detail pharmacognostically the crude drug-Kalmi-Dalchini.
OR
Describe various methods used for extraction of volatile oil. Give chemistry of volatile oil.
2. Solve any five : 15
i) Differentiate between T.S. of fennel fruit and T.S. of coriander fruit.
ii) Give biological source, chemical constituents and uses of quassia.
iii) Draw a well labeled diagram of T.S. of Eucalyptus leaf.
iv) State inter-relationship between cardiac glycosides of Digitalis purpurea and Digitalis lanata.
v) How bees wax is prepared ?
vi) Give chemical tests for the identification of aloes.
vii) Define glycoside. Classify them with examples.
3 . Write notes on (any three) : 15
i) Adulterants of liquorice
ii) Yam
iii) Chemistry of saponins
iv) Adulterants of Nux moschata
v) Kokum butter.
1. Solve any one :
Define tannins. Describe properties, chemistry and classification of tannins. Write a note on Ashoka.
OR
Discuss in detail pharmacognostically the crude drug-capsicum.
2. Solve any five :
15
i) State the chemical constituents of tobacco.
ii) Differentiate between pale catechu and black catechu.
iii) Draw a well labeled diagram of T.S. of podophyllum rhizome.
iv) Give biological source, chemical constituents and uses of guggul.
v) State the principle of SFE.
vi) Explain froth floating technique.
vii) Describe micropropagation.
3. Write notes on (any three) : 15
i) Mutation
ii) Calamine
iii) Transgenic plants
iv) Derris root
v) Streptokinase.
Time : 3 Hours Max. Marks : 80
Instructions :1) Question No. 1 and 5 are compulsory. Out of the remaining attempt two questions from Section I and two questions from Section II.
2) Answers to the two Sections should be written in separate answer books.
3) Neat diagrams must be drawn whenever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. Write about the culture media used in plant tissue culture techniques and
requirements to set up the plant tissue culture laboratory. 10
2. a) Write about direct gene transfer methods in detail. 10
b) Enlist the methods for selection of clones. Explain any two of them. 5
3. a) What are various methods of plant tissue culture ? Explain in detail about the
haploid cultures. 10
b) What are the different types of animal tissue culture media ? Give advantages
and disadvantages of serum containing media. 5
4. a) Give principle and variants of polymerase chain reactions. 10
b) Write a note on scope and potential of Biotechnology. 5
SECTION - II
5. Write methods and applications of immobilization technology. 10
6. a) What factors should be considered in design of a fermentor ? Write different
means of maintaining aseptic conditions in the fermenter. 10
b) Write the principle and method of RIA in immunoassay. 5
7. a) Write different techniques of reducing bioload of waste water. Elaborate on
activated sludge process. 10
b) Give details of different filtration techniques used in downstream processing. 5
8. Write short on any three : 15
a) Somatostatin
b) Safety and purity of biotech products
c) Advantages of recombinant vaccines
d) Monoclonal antibody production.
B/I/11/535
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagram must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. A) Explain origin and theory of UV spectra. What are various interaction of
EMR with matter. 6
B) Explain the following terms : 4
a) Chromophore
b) Cut off wavelength of solvent
c) Monochromator
d) Excitation of spectra.
2. A) What is polarogram ? What are factors affecting diffusion current ? 8
B) Explain instrumentation of polarography. Write in detail about DME. 7
3. A) What are the standard electrode and indicator electrode used in potentiometry ?
Write construction and working of combined glass electrode used in pH metry. 8
B) What is the cell constant of conductivity metre ? How it is related with
conductance ? 7
4. Write a note on any three : 15
a) Optical rotatory dispersion and CD
b) Differential scanning calorimetry
c) Fundamental laws of absorption of EMR
d) Amperometric titrations.
5. A) What is chromatography ? What are different principles of chromatographic
technique ? 5
B) Explain Van Deemter equation w.r.t. importance in setting column condition. 5
6. A) Write how fluorescence and concentration of material is related. Explain the
terms : singlet state and intersystem crossing. 7
B) In photoflurometer, primary and secondary filters at 90. Explain. 4
C) What are the factors affecting fluorescence ? 4
7. A) What is principle of radioimmunoassay ? Enlist application of it. 8
B) Write apparatus and techniques of coluometric methods of analysis. 7
8. Write a note on any three : 15
a) Adsorbents used in TLC
b) Principle and applications of Nephelometry
c) Abbes refractometer
d) Photo multiplier tube.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question number 1 and 5 are compulsory. Out of the remaining attempt any 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate book.
3) Figures to the right indicate full marks.
SECTION - I
1. Discuss the mode of action, efficacy and drug interactions of oral contraceptives. 10
2. Classify bronchodilator drugs. Give rational approaches of pharmacotherapy of asthma. 15
3. Classify cholinomimetic agents with examples. Explain the treatment of organophosphorus poisoning. 15
4. Write a note on any three : 15
A) Muscarinic receptors B) Glaucoma
C) Insulin preparations D) Corticosteroid antagonist.
SECTION - II
5. Write the pharmacological account on barbiturates. 10
6. Classify NSAIDs. Explain the pharmacology of Aspirin. 15
7. a) Explain the pharmacotherapy of rheumatoid arthritis. 15
b) Write the pharmacological account on antianxiety agents.
8. Write a note on any three : 15
A) Pharmacotherapy of Alcoholism B) Tricyclic antidepressants
C) Opoid dependence D) Halothane.
Fourth Year B.Pharm. Examination, 2011 PHARMACOGNOSY - III (2004 Course) Pharmacognosy and Phyto-Chemistry - III
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books
3) Neat diagrams must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. Answer the following questions in brief : 10
i) Write two microscopical differences between Cinchona bark and Kurchi Bark.
ii) What are protoalkaloids ? Give examples with structure of atleast one.
iii) State the hydrolysis product of
a) Atropine b) Cocaine
iv) What is Cinchona Red ? What is its importance in Cinchona Bark ?
v) Write pharmacological significance of
a) Colchicine b) Solasodine
vi) Describe the ring system for purine alkaloids. Give the chemical test to detect them.
2. A) Describe in details method of extraction of opium alkaloids. State their
pharmacological significance. 5
B) Draw a well labelled diagram of T.S. of Ephedra; enlisting their important diagnostic features. 5
C) Differentiate between the following crude drugs with atleast five differentiating features. 5
i) Brazillian Ipecac and Panama Ipecac.
ii) Lobelia I.P. and Lobelia B.P.
3. A) Explain life cycle of ergot with a brief note on saprophytic production of
ergot alkaloids. Give their pharmacological significance. 5
B) State the applications of medicinal plant tissue culture with reference to clonal propagation and cell immobilisation. 5
C) Write a note on tropane alkaloids. 5
4. Write notes on (any three) : 15
a) Gulvel and Brahmi
b) Plant allergens and allergenic extracts
c) Marine anticancer drugs
d) Rauwolfia alkaloids-chemistry and pharmacology.
SECTION - II
5. A) Describe the principle behind determination of following evaluation
parameters as per WHO guidelines. 5
i) Bitter value ii) Pesticide residue.
B) Describe the procedure for extraction and structural illucidation (by
instrumental technique) of Atropine or Quinine. 5
6. A) Write an elaborate note on various plant based industries in India. 5
B) Describe principle and procedure of super critical fluid extraction technique. Enlist various applications in isolation of phytoconstituents. 5
C) What do you understand by phytochemical investigation of a crude drug ? What is its role in herbal drug research ? 5
7. A) What is the method of preparation of Taila ? Enlist its evaluation parameters
and marketed preparations. 5
B) What is Froth. Floatation technique ? Explain how it can be utilized in extraction and isolation of herbal constituents ? 5
C) Write an elaborate note on Bhasmas. 5
8. Write note on (any three) : 15
a) Determination of Tannin content as per WHO guidelines.
b) Extraction of caffeine.
c) Formulation and evaluation of skin cosmetics.
d) Regulatory aspects of herbal drugs import and export.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question No. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. Explain design, construction and working of HEPA filter unit. Give its evaluation and validation tests. 10
2. Explain importance of Validation Master Plan (VMP) in pharmaceutical industry. 15
3. What are the sources for particulate matter in parenterals ? Which methods are used to detect the same ? What is the limit for particular matter in parenterals as per Pharmacopoeia ? 15
4. Write short notes on (any three) : 15
a) Intraperitoneal dialysis fluid
b) Optimization methods in pharmaceuticals
c) Quality control tests for parenterals
d) Drawbacks of conventional ophthalmic preparations
e) Preformulation studies for parenteral proteins and peptides.
5. What are the techniques used for filling of aerosols in containers ? Explain different types of aerosol systems. 10
6. Enlist methods for preparation of microencapsules. Explain coacervation phase separation method with examples. Discuss applications of microencapsules. 15
7. How controlled release system differs from sustained release system ? What is the rationale for selection of drug candidates for controlled drug delivery systems ? Discuss oral controlled release dosage forms. 15
8. Write short notes on (any three) : 15
a) Polymers for modified drug delivery systems
b) Interfacial polymerization
c) Osmotic drug delivery system
d) Probiotics
e) Iontophoretic drug delivery system.
B/I/11/3,505
Time : 3 Hours Max. Marks : 80
Illllllllllllllllllll
Instructions : 1) Question No. 1 and 5 are compulsory.
2) Out of the remaining, attempt two questions from Section I and two questions from Section II.
3) Answers to the two Sections should be written in separate answer books.
4) Figures to the right indicate full marks.
5) Draw well labeled diagrams wherever necessary
SECTION - I
1. a) Explain spin-spin coupling and chemical shift. 4
b) Explain how spin-spin coupling is useful in structural elucidation. 6
2. a) Explain in brief, Analytical Method Validation as per ICH guidelines. 9
b) Explain the terms ENDOR and ELDOR. 6
3. a) Describe various sample handling techniques for solid samples in IR. 8
b) Discuss various types of mass anlayser in mass spectroscopy. 7
4. Write short notes on any three : 15
a) Raman spectroscopy
b) X-ray diffraction methods
c) Difference between atomic absorption and flame emission spectroscopy
d) FTIR.
5. a) Write in brief theory of Gas Chromatography. 5
b) Explain band broadening and HETP in gas chromatography. 5
6. a) Discuss various types of pumps used in HPLC. 8
b) Write in brief about trouble shooting and quantitation technique in HPLC. 7
7. a) Give the application of HPTLC. 6
b) Explain simulated moving bed technology and principle of super critical fluid extraction. 9
8. Write short notes on any three : 15
a) Different modes of electrophoresis
b) Nuclear reaction and radiation
c) Detectors in gas chromatography
d) Horizontal TLC.
Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt two questions from Section I and two questions from Section II.
Time : 3 Hours
2) Answers to the two Sections should be written in separate books.
3) Neat diagram must be drawn whenever necessary.
4) Black figures to the right indicate full marks.
SECTION - I
1. A) What is a graphical representation of data ? Give the limitation of graphical
representation. 5
B) Draw less than ogive curve for the following data : 4
|
Class |
20-25 |
25-30 |
30- 35 |
35-40 |
40 - 45 |
45-50 |
|
F |
10 |
15 |
50 |
55 |
40 |
19 |
C) State the merits and demerits of median. 3
2. A) Describe test procedure for testing single population mean if sample size is
4
5
small.
B) Find Mean and Mode for the data given below :
14, 15, 13, 12, 11, 09, 14, 10, 13, 14, 15, 14, 16, 12, 13
C) Calculate coefficient of correlation between X and Y from the data given below :
|
X |
50 |
62 |
72 |
25 |
20 |
60 |
60 |
|
Y |
48 |
65 |
74 |
33 |
25 |
55 |
66 |
[3956] - 107
B) A die is rolled 5 times. Find the probability of getting 3 or 4 at most
-2-
2 times on uppermost face. 5
C) Find the median from the following distribution of 100 persons by age. 5
| ||||||||||||||
|
4. A) Calculate standard deviation from the following data : 5 |
|
Marks |
0-10 |
10-20 |
20-30 |
30-40 |
40-50 |
|
No. of students |
2 |
4 |
8 |
4 |
2 |
B) The equation of two lines of regression obtained in a correlation analysis are 4x - 5y + 33 = 0 and
20x - 9y - 107 = 0 Find :
i) The means values of x and y
ii) Coefficient of correlation between X and Y. 4
C) Write a note on Stratified Random Sampling. 5
SECTION - II
5. A) How many computer generation have evolved until now ? Explain each. 5
B) Explain characteristics of computer. 4
C) Which software is used for preparing presentation slides ? Explain. 3
6. A) Explain the important features of Windows operating system. 4
B) Convert (1101.11)2 binary number to its decimal equivalent. 5
C) What is software ? Explain the classification of software. 5
7. A) Differentiate between Hard Disk Drive (HDD) and Floppy Disk Drive
(FDD). 4
B) Explain working of Dot matrix printer. 5
C) Write a short note on : 5
i) ASCII
ii) GUI.
8. A) Define computer. Draw and explain the basic block diagram of computer. 5
B) Explain any one output device used in computer system. 4
C) Write the advantages and disadvantages of computer, 5
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answer 3 questions from Section I and 3 questions from Section II.
2) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
3) Answers to the two Sections should be written in separate books.
4) Neat diagrams must be drawn wherever necessary,
5) Black figures to the right indicate full marks.
SECTION -1
1. A) Define the following (any five): - S
i) Crude drug
ii) Evaluation of a crude drug
iii) Ash value
iv) Stomatal index
v) Pallisade ratio
vi) Adulteration.
B) State functions of the following tissues (any five):
i) Stomata
ii) Xylem
iii) Phloem
iv) Schlerenchyma
v) Chollenchyma
vi) Trichomes.
2. A) Describe in details Anatomy and Histology of Barks.
B) What are leaf constants ? Explain with suitable examples how leaf constants help in identification and authentification of leaves.
3. A) Explain how diagnosis and treatment of a disease is done in Ayurvedic
system of medicine.
B) What are various methods of cultivation of a crude drug ? Mention their advantages and disadvantages.
4. Write short note on (any three):
a) Plant growth regulations
b) Pests and pest control
c) Chemical classification of a crude drug
d) Ergastic cell context.
SECTION - II
5. Give biological source and pharmaccutical uses of the following:
i) Agar
ii) Acacia
iii) Locust bean gum
iv) Carrageenan
v) Inulin.
6. A) Explain the method of manufacturing and preparation of wheat, maize and
rice starch.
B) What are various sources of pectin ? How is pectin isolated from them ? Give its pharmaceutical applications.
7. A) Write specific importance of the following: 8
i) Ash value
ii) Karl Fischers method
iii) Water soluble extractive value
iv) Phloroglucinol and Sudan Red III.
B) Define Sophistication. How and why the intentional adulteration is done ?
Explain with appropriate examples. 7
8. Write short note on (any three): 15
a) Preliminary phytochemical screening
b) Honey
c) Cellulose and cellulose derivatives
d) Natural sweeteners.
Second Year B. Pharmacy Examination, 2011 23 : PHARMACEUTICAL ANALYSIS-1 (2008 Pattern)
Max, Marks: 80
Time : 3 Hours
Instructions: I) Answer three questions from. Section I and three questions
from Section II.
2) Question Nos. one and four are compulsory.
3) Answer to the two Sections should be written in separate hooks.
4) Black figures to the right indicate full marks.
SECTION - I
1. Solve any one :
i) What is buffer index ? Explain buffer in detail. Write equation to calculate pH of buffer solution. Discuss various types of solvents'used'in non aqueous
10
titration.
ii) Explain in details about applications and instrumentation of polarimeter. Define
specific and molecular rotation.
10
15
2. Solve any five :
i) Classify chemical indicators with suitable examples.
ii) What is cotton effect ?
iii) Discuss on sodium nitrate titration,
iv) Write down assay of titanous chloride.
v) Explain the principle of permanganate titration.
vi) Discuss in brief Ostwald theory.
vii) Enlist various conditions used in iodometric determination.
3. Write notes on (any three): 15
i) High frequency method
ii) Redox indicators
iii) Theory of optical activity
iv) Iodine titration
v) Pharmaceutical application of non aqueous titration.
4. Classify electrodes potentiometry and add a note on glass elcctrode. Discuss
on mixture analysis in copmlcxometric titration. 10
OR
What is co-precipitation and how it is reduced ? Give the application of gravimetric analysis.
5. Solve any five : 15
i) Discuss on metalochromic indicators.
ii) Explain chelation and coordination number.
iii) Write down assay of calcium gluconate as per I.P.
iv) Discuss on post precipitate.
v) Give the classification of errors and mean to minimize errors.
vi) Explain masking and dcmasking phenomenon.
vii) Why Eoson is used in acidic condition ?
6. Write short notes (on any three): 15
i) Applications of pH and potentiometry
ii) Types of EDTA titrations
iii) Kfajans method
iv) Oxygen flask combustion
v) Filtration.
Third Year B. Pharmacy Examination, 2011 PHARMACEUTICS - III (2004 Course)
Time: 3 Hours' Max. Marks: 80
Instructions : 1) Question Nos. I and 5 are compulsory. Out of the remaining attempt two questions from Section I and two questions from Section II.
2) Answers to the two sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.
SECTION -1
1. Discuss in detail any five defects in process of film coating of tablets and suggest remedies to each. 10
2. A) Explain manufacture of gelatin from raw material and explain various steps in
manufacture of empty hard gelatin capsules. 8
B) Write a detail account of biopharmaceutical aspects regarding development of pharmaceutical product. 7
3. A)Explainvariousexcipientsusedintablctformulationandtheirroleintabletting. 8
B) Give detail account of nature of gelatin used in manufacture of soft gelatin capsule. Add a note on role of plasticizers in soft gelatin capsule. 7
4. Write short notes on (any three): 15
1) Chcwable tablets
2) Physics of compression
3) Extrusion spheronization
4) Polymorphism in prcformulation studies.
5. What are hair care preparations ? Write in detail formulation aspects of shampoo. 10
6. A) Write in detail different methods of preparation of ointment with suitable
examples. 8
B) Give an account of evaluation of suspension. 7
7. A) What arc principles of effectiveness of sunscreen preparations ? Explain
with examples. 8
B) What are pharmaceutical considerations in development of body cosmetic products ? 7
8. Write short notes on (any three): 15
1) Equipments used in manufacturing of suspension and emulsion
2) Beeswax-borax creams
3) Multiple emulsions
4) Displacement value.
Time: 3 Hours Max. Marks: 80
iuii mill iiiiii nimu
Instructions: I) Question No. I and 5 are compulsory. Out of the
remaining attempt any two questions from Section I and two questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.
SECTION -1
I. Answer the following:
a) Differentiate between the following:
i) Sumatra Benzoin and Siam Benzoin
ii) CardenolidesandBufTadenolides 4
b) Explain and give the significance ofDott test. 3
c) Explain and give the significance ofBomtragers test and Modified Bomtragers test. 3
2. A) Define and classify the Volatile oils in detail. Explain different methods used
to obtain the volatile oils. 8
B) Give the pharmacognostic account on Clove. 7
3. A) Give the methods of preparation of the following: 9
i) Cod liver oil ii) Silk iii) Bromelein
B) Define and classify Tannins. Give their chemical tests and explain its
importance. 6
4. Write short notes on (any three) : 15
i) Asafoctida
ii) Fenugreek and Chicory
iii) Drugs from mineral origin
iv) T.S. of Fennel.
SECTION - II
5. A) Explain the following: 6
i) Keller-Killani test
ii) Cupraolintest.
B) Give Synonym, Biological source, chemical constituents and uses of: 4
i) Indian saffron ii) Himalayan May apple
6. A) Define and classify Glycosides in detail. Give the biosynthesis oflhe
glycosides. 6
B) Give the Pharmacognostic account on Mulethi. 9
7. A) Define and classify Lipids. Give the methods of extraction of Lipids. 6 B) Explain the evaluation parameters of Lipids. 9
8. Write short notes on (any three): 15
i) Natural Fibres
ii) Tracertechniquesandtheirapplications
iii) Ginger
iv) T. S. of Capsicum.
Illllllllllll lllll llll [3956] - 202
Second Year B. Pharmacy Examination, 2011 (2008 Pattern) 2.2 : PHARMACEUTICAL MICROBIOLOGY AND IMMUNOLOGY
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 01 and 05 are compulsory. Out of the
remaining attempt 2 questions from Section 1 and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. Answer the following (any five) : 10
a) Give the different applications of microbiology in pharmacy.
b) Why cedar wood oil used with oil-immersion objective ?
c) Differentiate between Cell wall of Gram Positive and Gram negative bacteria.
d) Write the characteristics of Salmonella.
e) Explain the term Prions.
f) Write morphological characteristics and importance of Saccharomyces Cervisiae.
2. a) Describe the basic requirement for Growth of bacteria. Write a note on
synchronous growth. 8
b) What are different sources for microbial contamination of pharmaceutical products ? How will you Assess microbial contamination of pharmaceutical product ? 7
3. Answer the following : 15
a) Explain the various approaches used in isolation of actinomycetes.
b) Describe in detail Fluorescence microscopy.
c) Explain in detail multiplication of human viruses.
4. Write a note on (any three) :
a) Factors affecting on preservative efficacy.
b) Shapes of bacteria
c) Robert Koch
d) Disease causing Rickettsia.
SECTION - II
5. Answer the following (any five) :
10
ii) Antiseptic
a) Define :
i) Virulence
b) What are opsonins ?
c) How will you validate HEPA filter ?
d) Give the classification of Immunological products.
e) Differentiate between Active immunity and passive immunity.
f) Enlist biological indicators for monitoring sterilization processes.
6. a) How will you Perform sterility testing of pharmaceutical products as per I. P. 8
b) Explain in detail monoclonal antibody production and write application of
monoclonal antibodies. 7
7. Answer the following : 15
a) Explain in brief different methods used for evaluation of disinfectant.
b) How will you perform microbial assay of penicillin ?
c) Explain in short the method of preparation, storage and dose of diptheria
antitoxin.
8. Write a note on (any three) :
15
a) Sources of contamination in aseptic area.
b) Determinants of Virulence.
c) Properties of Antigens.
d) Type III hypersensitivity.
Illllllllllllllllllllll
Third Year B. Pharmacy Examination, 2011
3.7 : PHARMACEUTICAL BUSINESS MANAGEMENT (2008 Course)
Max. Marks : 80
Time : 3 Hours
Instructions : 1) Answers to the two Sections should be written in separate
books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory
SECTION - I
1. Explain in brief concept of material management in pharmaceutical industry. 10
2. Answer any five (each three marks) :
15
a) Explain important steps in planning.
b) Explain the functions of Q. C. department.
c) Give various methods of purchasing.
d) Give causes of Industrial Disputes.
e) What is need for new product development, branding and packaging in product management ?
f) Explain importance of validation in manufacturing process.
3. Write short note on (any three) : 15
1) R and D in pharma. industry
2) Importance and functions of management
3) Decision making
4) Management by objective.
4. Define pricing. Explain factors affecting pricing and various methods of pricing. 10
5. Answer any three :
15
a) Write a note on product life cycle.
b) Write role and qualities of medical representative.
c) What are different types of communication ?
d) Define motivation. Write its significance and explain Maslows theory of motivation.
6. Write short note on (any three) : 15
a) Regulatory agencies
b) Documentation
c) Sales promotion
d) Channels of distribution.
Max. Marks : 80
Illllllllllllllllll
Time : 3 Hours
Instructions : 1) Question no. 1 and 5 are compulsory. Out of the remaining attempt two questions from Section I and two from Section II.
2) Answer to the two Sections should be written in separate books.
3) Figures to the right indicate full marks.
SECTION - I
1. Write structure, IUPAC name and mechanism of action of the following
12
any three :
1) Ketoconazole
2) Melphalan
3) Metronidazole
4) Trimethoprim.
2 . A) What are antibiotics ? Explain with examples the development of acid and
enzyme resistant penicillines. 7
B) Write the mode of action and synthetic steps for Clotrimazole. 7
3 . A) What is cancer ? Classify anticancer agents with examples. 7
B) Discuss the chemistry of alkylating agents with mode of action. 7
4. A) What is fungal infection ? Add a note on imidazole antifungals. 7
B) Explain the chemistry of Tetracyclines. 7
5. A) What is viral infection ? Classify antiviral drugs with examples. 6 B) Write a note on the development of reverse transcriptase inhibitors. 6
6. A) What are antimetabolites ? Classify the chemotherapeutic agents acting as
antimetabolites with examples. 7
B) Write the synthesis for Pyrimethamine. 7
7. A) What are sulphonamides ? Discuss the physicochemical properties and SAR
for sulphonamides. 7
B) What is synergism ? Explain synergism of sulphonamides with DHFR
inhibitors. 7
8. Write note on any two : 14
1) Mode of action of quinolone antibacterials
2) HIV protease inhibitors
3) Sources of lead structures in drug design.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question No. 1 and 5 are compulsory. Out of the remaining
attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Figures to the right indicate full marks.
SECTION - I
1. Discuss in detail the constitution, functions and working of pharmacy council
of India. 10
2. A) Discuss the conditions for the grant or renewal of license for manufacture of
drugs other than those specified in schedule C, C1 and X. 9
B) Labelling of vaccines and opthalmic preparations. 6
3. A) Discuss formula for calculation of retail price of formulation. 6
B) Define Cannabis. Discuss various penalties under NDPS Act. Discuss the powers the power of central government to permit and regulate certain operations relating to Narcotic Drugs and Psychotropic Sub. Act, 1985. 9
4. Write short notes on (any three) : 15
1) Education regulation
2) Cyber law
3) Public analyst
4) Industrial safety and health.
5. What is Hatch Waxman Act with reference to generic drugs, add note on ANDA and bioequivalence. 10
6. A) Discuss in brief about : 8
a) Electronic submission
b) Investigation new drug application.
B) Discuss general procedure for securing patents in India. 7
7. A) Discuss in brief salient features of Indian Patent Act, 1970. Discuss provision
of compulsory license. 7
B) Discuss WHO Guidelines. 8
8. Write a short note on (any three) : 15
a) DMF
b) TGA
c) MCA
d) BLA.
Third Year B. Pharmacy Examination, 2011 (2008 Pattern) 3.5 : PHARMACOLOGY - II
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory
SECTION - I
1. Classify p blockers. Explain the pharmacological actions, adverse effects and therapeutic uses of p blockers. 10
OR
1 . Explain the mechanism of action, the pharmacological actions, adverse effects and therapeutic uses of Atropine. 10
2. Answer any five :
a) What are the therapeutic uses of a adrenergic blockers ? 3
b) Explain the metabolism of Adrenaline and noradrenaline. 3
c) Classify opioid analgesics. 3
d) Classify the drugs used in the treatment of parkinsonism. 3
e) What is preanaesthetic medication ? Explain in brief. 3
f) What are the advantages of benzodiazepines over barbiturates ? 3
g) What are the therapeutic uses of adrenaline ? 3
3. Write short notes on any three :
a) Morphine poisoning. 5
b) Biphasic response and Dales vasomotor reversal. 5
c) Treatment of Alzhimers disease. 5
d) Tricyclic antidepressants. 5
e) Status epilepticus. 5
P.T.O.
SECTION - II
4. Explain in detail the pharmacotherapy of peptic ulcer. 10
OR
4. Explain the mechanism of action, the pharmacological actions, adverse effects and therapeutic uses of insulin. 10
5. Answer any five :
a) Explain the mechanism of action of local anesthetics. 3
b) What are the therapeutic uses of oxytocin ? 3
c) Classify antiemetics. 3
d) Classify laxatives. 3
e) What is the mechanism of action of oral contraceptives ? 3
f) Classify antiasthmatics. 3
g) Write a brief note on glucagon. 3
6. Write short notes on any three :
a) Calcitonin. 5
b) Emetics. 5
c) Sulphonylureas. 5
d) Pharmacotherapy of cough. 5
e) Antithyroid drugs. 5
First Year B.Pharmacy Examination, 2011 1.3 : PHARMACEUTICAL INORGANIC CHEMISTRY (2008 Pattern)
Max. Marks: 80
Time: 3 Hours
Instructions : 1) All questions are compukory.
2) Answers to the two Sections should be written in separate answer books.
3) Figures to the right indicate full marks.
SECTION -1
1. Discuss the various sourccs of impurities in pharmaceutical substances. 10
1. Define the terms Hard Water and Soft Water. Distinguish between permanent and temporary hardness of water. Discuss official tests applicable to official waters.
2. Attempt any five of the following :
15
a) Explain in brief radio-opaque substances with examples.
b) Name and explain subatomic particles.
c) Explain ash value and its significance.
d) Why stannated hydrochloric acid is used in limit test for arsenic ?
e) Explain the terms preservative and diluent with examples.
f) Give the method of preparation, properties and uses of nitrous oxide.
g) Enlist different waters official in IP and explain sterile water for injection.
3. Write notes on any three of the following :
a) Properties, uses and assay of oxygen
b) Antioxidants
c) Various identification tests as per IP
d) Limit test for sulphate
e) Handling and storage of radioactive materials.
SECTION - II
4. Discuss the method of preparation, uses and assay of compounds used in cyanide poisoning. 10
OR
4. Discuss the methods of preparation, uses and assay of magnesium carbonate and calcium phosphate.
5. Attempt any five of the following: 15
a) Explain the properties, uses and assay of iodine solution IP.
b) What is metabolic acidosis ?
c) Enlist official sodium chloride formulations used in electrolyte replacement therapy.
d) Describe preparation, uses and assay of sodium fluoride.
e) Explain the reactions involved in assay of potassium iodide.
f) Discuss role of zinc and its salts as essential and trace ion.
g) Describe with principle and reactions assay of hydrogen peroxide.
6. Write notes on any three of the following : 15
a) Assay of boric acid IP
b) Mechanism of action of topical agents
c) Copper sulphate
d) Physiological role of chloride and bicarbonate
e) Assay of potassium permanganate.
Illllllllllll lllll lllllll [3956] - 202A
Second Year B.Pharmacy Examination, 2011 (2008 Pattern) 2.2 : PHARMACEUTICAL MICROBIOLOGY AND IMMUNOLOGY
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory
SECTION - I
1. Explain different methods used for isolation of bacteria and write a note on
Colony characteristics. 10
OR
1. List different types of microscopy. Explain in detail electron microscopy. 10
2. Answer the following (any five) : 15
a) Differentiate between Gram positive and Gram negative cell wall of bacteria.
b) Write the characteristics of Escherichia.
c) Draw and explain in short growth curve of bacteria.
d) What are the contributions of Robert Koch to microbiology ?
e) How will you isolate actinomycetes from soil ?
f) Write Whittakers five kingdom concept.
g) Differentiate between Lytic and lysogenic cycle of bacteriophage.
3. Write a note on (any three) : 15
a) Dermatophytes
b) Preservation of pharmaceutical products
c) Multiplication of human viruses
d) Rickettsia
e) Types of microbial spoilage.
4. Describe in detail monoclonal antibody production and explain its applications. 10
OR
4. What is microbial assay ? Discuss in detail general methods used for microbial
assay of antibiotics as per I.P.
10
5. Answer the following (any five) :
15
a) Differentiate between active immunity and passive immunity.
b) Explain in detail complement fixation test.
c) Explain in short designing of aseptic area.
d) What is D-value and write its significance ?
e) What is triple vaccine ? Explain.
f) Write biological indicators used for evaluating the sterilization process.
g) Write ideal properties of disinfectants.
6. Write a note on (any three) : 15
a) Determinants of virulence
b) Membrane filtration
c) Type I-hypersensitivity
d) Phenol coefficient test
e) Diphthertia antitoxin.
Time : 3 Hours Max. Marks : 80
Instructions : Question Nos. 1 and 5 are compulsory. Solve any two questions.from the remaining.
SECTION -1
1. Write note on following : 10
a) Ergastic cell contents
b) Cultivation of crude drugs
c) Quality control of crude drugs
d) Proper collection of crudc drugs.
2. A) Define neutraceuticals. Write about any three neutraceutical drugs. 8
B) Explain role of plant growth regulators in the production of good quality
crude drugs. 7
3. A) Define Pharmacognosy. Explain role of various scientists in the development
of Pharmacognosy. 8
B) Write note on ash value and its significance. 7
4. Write note on any three : 15
B) Adulteration of crude drugs
C) Absorbent cotton
D) Honey.
5. Answer the following :
a) What is Stomatal number ? Give its significance. 2
b) What is Papyrus Ebers ? 2
c) Define gum and mucilage. 2
d) Differentiate between organised drug and unorganised drug. 2
e) Describe the various shapes of bark. 2
6. A) Define carbohydrates along with its classification and chemistry. 8 B) Describe morphology and anatomy of bark drug. 7
7. A) Define primary and secondary metabolites in plants. Classify them with relation
to biosynthetic pathways. 7
B) Give two identification tests for following drugs : 8
i) Agar ii) Starch
iii) Guar gum iv) Acacia
8. A) Explain dermal tissue system in plants. Add a note on ergastic cell contents. 7
B) Define extraction. Which are various methods of extraction and explain their
lllilHllllllHIIIIII [3956] - 208
Second Year B.Pharmacy Examination, 2011 PHARMACEUTICAL ENGINEERING (2004 Pattern)
Time : 3 Hours Max Marks : 80
Instructions: 1) Q. No. 1 and 5 are compulsory, attempt any two questions from remaining three questions from Section I and three questions from Section II.
2) Answer to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary.
4) Black figures to the right indicate full marks.
SECTION -1
|
1. Explain the principle, construction and working of falling film evaporator and | ||||||||||||||||||||||||
|
5. Explain the different factors affecting drying of solids, also explain the behavior
of solid during drying. 10
6. a) Explain the principle of liquid-liquid extraction. 5
b) Explain the principle and working of centrifugal distillation. 5
c) Explain the different factors affecting corrosion. 5
7. a) Explain the principle of fractional distillation; how plate efficiency is calculated ? 10
b) Explain the working of extraction battery. 5
8. Write short notes on (any three): 15
a) Triangular diagram
b) Molecular diffusion in gases
c) Bernoullis theorem
d) Rotocel extractor.
Third Year B. Pharmacy Examination, 2011 (2008 Pattern) 3.1 : PHARMACEUTICS - II
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
4) All questions are compulsory
SECTION - I
1. Describe goals and importance of preformulation. Discuss bulk characterization
in detail. 10
2. Attempt any 3 : (5 Marks each)
a) Write a note on directly compressible vehicles.
b) Discuss defects encountered in tablet manufacture with causes and remedies.
c) Give an account of film formers in tablet coating.
d) Write a note on interaction of container and closure.
3. Attempt any 3 : (5 Marks each)
a) Discuss advances in tablet coating pans.
b) Describe problems encountered in formulation of dry filled capsules and considerations that go into selection of excipients.
c) Write a note on packaging and packaging materials used for tablets.
d) Write a note on CGMP guidelines.
4. Discuss the stability of suspension with the help of DLVO theory. Describe evaluation of suspensions 10
5. Attempt any 3 : (5 Marks each)
a) Write a note on antiperspirants and deodorants.
b) Give composition of lipstick and evaluation test for lipstick.
c) Write note on penetration enhancers.
d) Describe the stability testing of emulsions.
6. Attempt any 3 : (5 Marks each)
a) What are cosmeceutical ? Describe the importance of hydroxy acids as cosmeceutical.
b) Give comparative account of cold cream and vanishing cream.
c) Write a note on wet shave preparations.
d) Describe hair colouring preparations.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Answers to the two Sections should be written in separate books.
2) Neat diagrams must be drawn wherever necessary.
3) Black figures to the right indicate full marks.
SECTION - I
1. Attempt any one : 10
Describe goals and importance of preformulation. Discuss bulk characterization in detail.
OR
Discuss granulation processes. Give elaborate account of advances in granulation methods.
2. Attempt any five (each 3 marks) : 15
a) Give an account of material used for tablet packing.
b) Explain the significance of base adsorption .
c) Explain disintegration test for tablets.
d) Explain the problem of picking and sticking in tablet manufacture.
e) Give biopharmaceutical aspects of dosage form design.
f) Describe interaction of dosage forms with containers.
g) What are JCH guide lines ?
3. Attempt any three (each 5 marks) : 15
a) Give an account of film formers in tablet coating.
b) Discuss various perforated pans used in tablet coating.
c) Write a note on gelatin in capsule manufacture.
d) Describe formulation of effervescent tablets.
e) Describe compression cycle in rotary tablet machine.
4. Attempt any one :
Discuss the stability of suspensions with the help of DLVO theory. Describe evaluation of suspension.
10
OR
Give an elaborate account of various ointment bases. Add a note on routes of transdermal permeation of drug.
5. Attempt any five (3 marks each) :
15
a) Evaluation tests of lipstick.
b) Use of hydioxy acids as cosmeceuticals.
c) Give ideal requirements and formulation of lather shaving cream.
d) Describe additives used in suspension.
e) Explain importance of diluent : solvent ratio in nail lacquer.
f) Describe tests for evaluation of emulsions.
g) Explain concept of phase inversion temperature.
6. Attempt any three (each 5 marks) : 15
a) Give an account of penetration enhancers.
b) Write a note on chemical depilatory.
c) Explain difference between temporary, semi permanent and permanent hair colours. Give an account of permanent hair colorants.
d) What are the principles of action of sunscreen ? Give ideal properties of sunscreen preparations.
e) Give an account of equipments used in manufacture of semisolids.
Time : 3 Hours Max. Marks : 80
Note : 1) All questions are compulsory.
2) Answers to the two Sections should be written in separate answer books.
3) Figures to the right indicate full marks.
4) Correct structure and neat diagrams must be drawn wherever necessary.
SECTION - I
1. Solve any one :
I) Give the classification of anticonvulsant drugs on the basis of chemical
structures. Give the MOA, SAR of Hydantoins. 10
II) Describe the Chemistry, Pharmacological actions, SAR and Metabolism of acetyl choline. 10
2. Attempt any five of the following : 15
a) Outline synthesis of Nikethamide.
b) Classify oral Hypoglycemic agents with examples.
c) Discuss about adrenergic receptors and classify adrenergic agents.
d) Draw Synthesis of Doxepin.
e) What are major pathways of drug metabolism ? Explain Phase I reactions.
f) Give an account of forces involved in drug receptor interaction.
g) Classify antiarrythmic agents with examples.
3. Write notes on (any three) : 15
a) Preanaesthetic medication
b) SAR of Sympathomimetic agents
c) Discuss MOA, SAR of Benzodiazepines
d) Drugs used in Parkinsons disease
e) MAO inhibitors.
4. Classify sedative and Hypnotics. Give MOA, SAR of Barbiturates.
OR
10
6
4. a) Discuss in detail the SAR studies of tricyclic antidepressant agents along with
suitable examples.
b) Give the classification of neuromuscular blocking agents on the basis of MOA. 4
5. Attempt any five of the following :
15
a) Outline synthesis of Diphenhydramine.
b) Discuss ester based local anaesthetics.
c) Classify with suitable examples and give the mode of action of cardiotonics.
d) Outline synthesis of Guanethidine Monophosphate.
e) What is difference between sedatives, hypnotics, anticonvulsants and general anaesthetics ?
f) Elaborate various factors affecting drug-protein binding.
g) Discuss the process of metabolic inactivation of norepinephrine in the body.
6. Write notes on (any three) : 15
a) Antimigraine agents
b) CNS stimulants drugs
c) ACE inhibitors
d) Hallucinogens
e) Volatile anaesthetics.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate answer books.
3) Neat diagrams must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. A) Explain Van Deemters equation in detail. How it helps to improve column
performance ? 6
B) Write the theory of UV-Vis spectroscopy. 4
2. A) Draw a neat diagram of DME and explain its functioning along with advantages
and limitations of the DME. 7
B) What are salient features of Polarogaph ? Discuss the factors affecting limiting current. 5
C) What is half wave potential ? Give its significance. 3
3. A) State the principle of fluorimetry. Draw a neat labeled diagram of fluorimeter. 7
B) Discuss the factors affecting fluorescence. 5
C) What is singlet state, triplet state and quenching ? 3
4. Write a note on any three : 15
a) Advantages and limitations of Amperometric titrations
b) Potentiostatic Coulometry
c) Radiation sources in UV-Vis spectrophotometry
d) Measurement of angle of refraction.
5. A) Explain the following terms :
1) Molar absorptivity
2) EMR
3) Wavelength
4) Retention time. 4
B) Discuss in brief about filters and monochromators used in UV-Vis
spectroscopy. 6
6. A) What are different methods of thermal analysis ? Explain the factors affecting
thermogravimetric results. 7
B) Explain the difference between Nephelometry and Turbidometry. Give the
instrumentation and applications of turbidometric analysis. 8
7. A) Describe Principle and applications of flame photometry. 7
B) Draw a neat labeled diagram of flame photometer. Explain the functioning of each part. 8
8. Write a note on any three : 15
a) Adsorbants used in TLC
b) Merits and demerits of instrumental analysis
c) DTA
d) Applications of fluorimetry.
SECTION - I
Time : 3 Hours
Max. Marks : 80
1. Explain in brief concept of material management in Pharmaceutical Industry. 10
OR
1. Explain in brief drug discovery and development process.
2. Answer any five (each 3 marks) :
15
a) Describe important steps in planning.
b) Explain the functions of Q.C. department.
c) Give various methods of purchasing.
d) Give causes of industrial dispute.
e) What is need for new product development, branding and packaging in product management ?
f) What is validation ? Explain its importance.
g) Explain break even analysis.
3. Write short note (any three) : 15
a) R and D in pharma industry.
b) Importance and functions of management.
c) Decision making.
d) Management by objective.
e) Current status and growth scenario of pharmaceutical industry.
4. Define pricing. Explain factors affecting pricing and various methods of pricing. 10
OR
4. Write qualities of leadership. Explain different styles of leadership.
5. Answer any five (each 3 marks) : 15
a) Explain product life cycle.
b) What are qualities and role of a medical representative ?
c) What is motivation ? Write its significance.
d) Write in brief about different types of communication.
e) Write techniques of sales promotions.
f) Write importance of marketing research.
g) Write in brief methods of advertising.
6. Write short note (any three) : 15
a) Regulatory agencies
b) Channels of distribution
c) Performance appraisal
d) Interview techniques
e) Maslow's theory of motivation.
Third Year B.Pharmacy Examination, 2011 PHARMACEUTICAL MARKETING AND MANAGEMENT (2004 Course)
Time : 3 Hours Max. Marks : 80
N.B. : 1) Q. No. one and five are compulsory.
2) Solve any two questions from Section I and Section II, respectively.
3) Figures at right indicate full marks.
SECTION - I
1. Solve the following : 5
A) Price per unit Rs. 10.00, variable cost is Rs. 5.00 and fixed cost is Rs. 20,00,000. Calculate : P/V ratio, BES, sales to earn profit of Rs. 50,00,000, profit at sales Rs. 1,00,00,000 and MOS.
B) Draw the network and find the critical path. 5
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7 |
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9 10 |
10 |
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2. A) What are the causes of industrial dispute ? Focus on collective bargaining.
B) Differentiate the terms purchasing and procurement. Give methods of purchasing.
3. A) Define planning. Give the process and importance of planning.
B) Explain the process of new drug discovery and development.
4. Write short note on (any three) :
A) PRIDE
B) Sales forecasting
C) Fundamental principles of organizing
d) TRIPS.
SECTION - II
|
5. A) From the following information prepare balance sheet of Jidnyasa Remedies. | ||||||||||||||||||||||||||||||||||||||||
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B) Purchase price per unit Rs. 60, purchase order cost Rs. 240, total requirement for a year 9000 units, carrying cost 20% of average inventory value; Calculate EOQ.
6. A) Explain ABC and VED analysis.
B) Explain product life cycle.
C) What are different styles of leadership ? Discuss about managerial grid.
7. A) Define price. What are the types and factors affecting the price ?
B) Explain in detail the classification of theories of motivation.
8. Write short note (any three) :
A) Marketing research B) Advertising C) PLC D) EOQ.
Time : 3 Hours Max. Marks : 80
Instructions : 1) Question Nos. 1 and 5 are compulsory. Out of the remaining attempt 2 questions from Section I and 2 questions from Section II.
2) Answers to the two Sections should be written in separate books.
3) Neat diagrams must be drawn wherever necessary
4) Black figures to the right indicate full marks.
SECTION - I
1. Explain the pharmacotechnical factors that influence GI absorption of a drug. 10
2. Why is distribution of a drug not uniform throughout the body ? Explain the different factors influencing drug distribution. 15
3. a) Explain the significance of protein tissue binding of drugs. 10
b) Renal excretion of penicillins is unaffected by protein-drug binding. Why ? 5
4. Write short notes on (any 3) : 15
a) pH partition hypothesis
b) Volume of distribution and its significance
c) Bioactivation and tissue toxicity
d) BCS and BDDCS.
SECTION - II
5. What are the various nonrenal routes of drug excretion ? 10
6. a) Discuss the different factors affecting the drug interactions. 7.5
b) Discuss the factors affecting drug dissolution. 7.5
7. Define and explain extraction ratio. How is it related to oral availability of a drug ? Explain the influence of blood flow rate and protein binding on total clearance of drugs with different ER values. 15
8. a) Discuss the factors affecting bioavailability of a drug. 8
b) Discuss the applications of pharmacokinetic principles. 7
B/I/11/3,505
Time : 3 Hours Max. Marks : 80
Instructions : 1) Q. No. 1 and Q. No. 5 are compulsory. Out of remaining
attempt two questions from Section I and two questions from Section II.
2) Answers to the two Sections should be written in separate answer books.
3) Figures to the right indicates full marks.
4) Correct structure must be drawn wherever necessary
SECTION - I
1. Explain cholinergic receptors. Classify cholinergic agents. Write SAR of ACh. 12
2. a) What are major pathways of metabolism ? Explain oxidation reactions in detail. 6
b) Classify sympathomimetic agents and add a note on mixed action drugs. 6
c) Draw synthesis of diazepam. 2
3. a) Classify general anasthetics and add a note on SAR, MOA of barbiturates. 6
b) Explain SAR, MOA and uses of tricyclic antidepressants. 6
c) Draw synthesis of imipramine. 2
4. a) Write notes on (any three) : 12
1) Drug receptor interactions
2) Hydantioins as anticonvulsants
3) Isosterism and biological activity
4) Free Wilson analysis.
b) Draw synthesis of thiopental sodium. 2
|
Classify antihistaminics in detail and write a note on Pheniramines. |
12 |
|
a) Classify diuretics agents and add a note SAR, MOA of site 3 diuretics. |
6 |
|
b) Classify antiarrythmic agents. Write MOA of each class. Add a note on | |
|
class I drugs. |
6 |
|
c) Draw synthesis of Diclofenac. |
2 |
|
a) Write Mechanism of action, SAR of salicylates and anilines as analgesics. |
6 |
|
b) Write a note on steroidal anti inflammatory agents. |
6 |
|
c) Draw synthesis of benzocaine. |
2 |
|
a) Write notes on (any three) : |
12 |
|
1) ACE inhibitor prodrugs | |
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2) Amide based local anesthetics | |
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3) Proton pump inhibitors | |
|
4) Antiandrogens. | |
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b) Draw synthesis of omeprazole. |
2 |
B/I/11/3,505
|
Attachment: |
| Earning: Approval pending. |
