Integral University 2011 M.Tech Biotechnology Bioinformatics genomics and proteomics - Question Paper
No. of Printed Pages - 2 MTBT-301
Roll No.
THIRD SEMESTER EXAMINATION, 2011-12 BIOINFORMATICS, GENOMICS & PROTEOMICS
Total Marks : 100
Note : (i) Attempt any FIVE questions;
(ii) Marks are indicated against each question
1. (a) What do you understand by transcriptome and transcriptomics?
Explain the process of separation and identification of proteome in proteame analysis. 10
(b) Briefly discuss the basic principle of DNA micro array and explain its applications. 10
2. Write explanatory notes on database similarity searching tool and also discuss various methods of Multiple Sequence Alignment (MSA). 20
Write short notes on the following :
(a) Application of Human Genome Project (HGP)
(b) Secondary protein database jc) Nucleotide Database
EST
3.
5 x 4 = 20
(d)
What is homology Modelling? Explain the basic steps involved in homology modelling. 20
Briefly discuss the following : 4 x 5 = 20
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(a) |
KEGG |
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fr) |
OMIM |
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(9) |
Chromosome walking |
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(d) |
Subtractive hybridization |
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Phylogenetic analysis |
6. Define Drug and Target. Discuss in detail the various phases of drug designing with special reference to Bioinformatics application. 20
7. Write short notes on any Four: 5 x 4 = 20
(a) Swiss prot
(b) SNPs
(c) Motifs
(d) Gene expression profiling
(e) Biological databases
2
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Attachment: |
| Earning: Approval pending. |
