Integral University 2011 M.Tech Biotechnology Bioinformatics - Question Paper
MTBT-301
B. Tech. - M. Tech. (DUAL) (BIOTECHNOLOGY)
NINTH SEMESTER EXAMINATION, 2010-11 BIOINFORMATICS, GENOMICS & PROTEOMICS
Time: 3 Hours
Total Marks : 100
Note : (i) Attempt any FIVE questions.
: (ii) Marks are indicated against each question
1, ; (a) What is NCBI? Enumerate few important resources available at
NCBI. 5
(b) What are data retrieval tools? Explain any one tool with suitable
applications. 5
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(c) What is homalogy modeling, explain it by giving different steps involve in it? 10
2. (a) Write short notes on any Two of the following : 10
(i) ESTs
(ii) b -jgical Databases
(iii) Gene Sequencing Tags (GSTs)
(iv) PubMed
(b) Define BLAST. Discuss several variants of BLAST. How is it different from FASTA? 10
3. Attempt any Four parts of following : 5 x 4 = 20
(a) Expand the following terms :
EMBL, SWISS-PROT, PROSITE and CATH
(b) Differentiate between local and global sequence aiignmsnt.
MTBT-301
(c) How is gene structure oredicted using bioinformatics tools?
What is multiple sequence alignment (MSA)? Mention its significance.
(e) Discuss the general software requirement specifications (srs) for developing a software tool for ORF finding.
4. Attempt any Four parts of following : 5 x 4 = 20
(a) What is SAGE? How it helps to study gene expression?
, (b) Write a brief account on Dideoxy method of DNA sequencing.
(c) Discuss the importance of genetic map of chromosomes.
(d) Discuss clone conting approach for genome sequencing.
(o) What are microarrays? Discuss applications of microarray analysis.
5. Attempt any Two parts of following : 10x2 = 20
(a) How is a new drug designed? Discuss important steps of drug designing.
(b) What is Phylogenetic analysis? Discuss tools for phylogenetic analysis
<c) Give a brief account on human genome project (HGP).
6. Attempt any Two parts of following: 10x2 = 20
(a) Signal peptide bank
(b) OMIM database
(c) Smith waterman algorithm
(d) Shot gun sequencing
2
Attempt any Two parts of following : 10 x 2 = 20
(a) Discuss the importance of protein-protein interaction studies.
(b) Discuss a suitable method for prediction of secondary structure of a protein.
(c) Differentiate between structural genomics and functional genomics.
(d) What is chromosome walking? How is it different from clone contig approach?
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