Integral University 2009 M.Tech Biotechnology Bioinformatics genomics and proteomics - Question Paper
HIRD SEMESTER EXAMINATION, 2009-10
BJOIN FORMATiCS, GENOMICS AND PROTEOMiCS
Time
Note
1.
2.
: (i)~ Attempt any FIVE questions.
(ii) Marks are indicated against each question.
(n) Explain the DNA rnicroL-aay and its applications in ce
(b) Explain Proteiri-Prolein interaction by different metnc<
Align the given two sequence globally by applying Needle algorithm using the flowing inputs:'
Match Score = +3 Mismatch Score =-1 Gap penalty = -2 Sequence 1: TAACGT Sequence 2: AGTCAA
Back trace the matrix to show all the alignments. What is the optimal alignment?
3. Explain any.Four in 80-100 words:
(a) Contings (b) Chromosome w
(c) Sho! gun sequencing (d) Maxam Giber' 5
t is Drug and Target? Explain in detail the entire process of drug T }ning in reference to use of latest Bioinformatics tools. 20
a-
out various algorithms available for Tertiary structure prediction oteins. Discuss the Homology Modeling methodology for tertiary -lure prediction in detail. 20 ~
i
short notes on the followings:
4 x 5 = 20
OMIM (b) PROSITE
Pfam (d) EMP
SWISS-PROT
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| Earning: Approval pending. |
