Tamil Nadu Dr MGR Medical University 2009 M.Pharm PHARMACEUTICAL CHEMISTRY - II – ADVANCED ORGANIC CHEMISTRY - - Question Paper

MARCH -2009
[KU 319] Sub. Code: 2855
M.PHARM. DEGREE exam
(Regulations 2006)
Candidates admitted from 2006-2007 onwards
FIRST YEAR
Branch II – PHARMACEUTICAL CHEMISTRY
Paper II – ADVANCED ORGANIC CHEMISTRY
Q.P. Code : 262855
Time : 3 hours Maximum : 100 marks
ans All ques.
I. Essay ques. : (3 X 20 = 60)
1. a) discuss the mechanism and reactivity of addition reaction to carbon –
hetero multiple bonds.
b) Write a note on delocallized chemical bonding.
c) Draw the Tablonski diagram and explain the energy transition.
2. a) explain the mechanism and reactivity of aliphatic nucleophilic substitution
reaction with example.
b) provide the application of Mannich reaction with suitable example.
c) provide the stability and structure of carbon ions.
3. a) elaborate the different kinds of pericyclic reactions, explain their
mechanisms.
b) discuss the asymmetric synthesis for preparing chiral drugs with an
example.
c) explain the synthones approach for carbon-carbon bond formation.
II. Write Short Notes : (8 X five = 40)
1. explain the Resonance and field effects of structure on reactivity.
2. provide the application of combinatorial chemistry.
3. Comment on the different reagents used for oxidation- reduction reactions.
4. explain the Michael reaction with an example.
5. Outline the synthesis of pyrrole and furan.
6. explain the synthetic utility of Grignard reaction.
7. discuss the phase transfer catalysis in anhydride..
8. elaborate the different approaches for deprotection of groups.

Earning:   Approval pending.