Tamil Nadu Dr MGR Medical University 2009 B.Pharm II – PHARMACEUTICAL ORGANIC CHEMISTRY Q.PCode : 564162 - - Question Paper

FEBRUARY - 2009
[KU 702] Sub. Code: 4162
FIRST B.PHARM. DEGREE exam
(ReRevised Regulations)Candidates Admitted upto 2003-04
Paper II – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code : 564162
Time : 3 hours Maximum : 90 marks
I. Essay ques. : ans any 2 ques.. (2 X 20 = 40)
1. a) discuss SN1 and SN2 reactions of alkyl halides and elaborate the factors influencing
the mechanism. (7)
b) Distinguish the features of the 2 SN1 and SN2 mechanism. (7)
c) Write note about Elimination Vs substitution. (6)
2. a) Enumerate and explain different methods available for the preparation of
Alkenes. (10)
b) provide the properties of alkenes. (10)
3. a) elaborate amines? How are they classified? explain the general methods
of preparations and properties of Aliphatic amines. (15)
b) Write 5 distinguishing tests ranging from primary, secondary and tertiary amines. (5)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. discuss aldol condensation reaction of aldehyde and ketones.
2. describe diazotization: Write the method of preparation of Benzene diazonium chloride.
3. Write the method of preparation of ethers by Williamson’s synthesis.
4. provide a brief account of large scale preparation of acetic acid.
5. Write any 2 methods of preparations of salicylic acid and its uses.
6. Write the preparation, properties and uses of Benzyl alcohol.
7. How chloroform is prepared industrially? Write the properties, analytical test and uses
of chloroform.
8. discuss Friedel – Crafts reaction with mechanism and its limitations.
9. What is hyperconjugation? discuss it and the usefulness of this concept.
10. discuss Hydrogenbond and the properties related with it.
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. discuss Bond fission.
2. Write the preparation of lactic acid from acetaldehyde.
3. Why aldehydes and ketones do not undergo nucleophilic substitution?.
4. discuss schiemann reaction: What is its utility?
5. provide IUPAC name of the subsequent compounds.
a) CH3 – C = C – CH3, b) CH2 = CH – CH = CH2
c) CH3 – CH – CH – CH2OH.
¦ ¦
BR CL
d) H – CHO
6. Write structures of the subsequent compounds: Whose IUPAC names ae provided under.
a) 1, five – hexadiene. b) four – methyl – two - pentyne.
c) one - methyl – two – pentene - 1-01 d) two – Brome butanoyl chloride.
7. How will you convert primary alcohol into secondary alcohol? – discuss.

Earning:   Approval pending.