Tamil Nadu Dr MGR Medical University 2009 B.Pharm II – PHARMACEUTICAL ORGANIC CHEMISTRY Q.PCode : 564227 - - Question Paper

FEBRUARY - 2009
[KU 736] Sub. Code: 4227
FIRST B.PHARM. DEGREE exam
(Regulations 2004)
(Candidates admitted from 2004-05 onwards)
Paper II – PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code : 564227
Time : 3 hours Maximum : 90 marks
I. Essay ques. : (2 X 20 = 40)
ans any 2 ques..
1. a) elaborate alcohols? Classify them. Outline the nomenclature, method of
preparation and chemical reactions of alcohols. (10)
b) discuss the mechanism of electrophilic addition reaction in alkenes. (10)
2. a) discuss the structure of benzene. (10)
b) define the chemical reactions of a, ß – unsaturated carbonyl
compounds. (10)
3. a) discuss the role of inductive effect and mesomeric effect in electron
displacement of molecule.
b) define any 2 methods to differentiate 1°, 2° and 3° amines. (10)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. Write the preparation of diazonium compounds. define its mechanism.
2. Write a short note on stability of carborium ions.
3. explain the basicity of amines.
4. How will you distinguish ranging from aldehydes and ketones?
5. Write a note on Bayer’s strain theory.
6. define the nucleophilic substitution reactions.
7. Write an explanatory note on ozonolysis reaction and its applicability.
8. discuss the method of Haworth synthesis for polynuclear hydrocarbons.
9. Outline the method of preparation, assay and uses of the following:
a) Glyceryltrinitrate. b) Benzoic acid.
10. discuss the phenomenon of tetrahedral hybridisation with suitable
examples.
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. What happens when, a) Naphthalene reacts with sodium and ethanol.
b) Naphthalene is heated with nickel.
2. What is hydrogen bonding? provide example.
3. Write the method of preparation, assay and uses of acetanilide.
4. Write a brief note on aromaticity.
5. describe saytzeff’s rule. provide example.
6. Mention the drawback of Friedel-Craft’s alkylation in benzene.
7. Write a note on mixed aldol condensation.

Earning:   Approval pending.