Tamil Nadu Dr MGR Medical University 2009 B.Pharm II – ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY Q.PCode : 564182 - - Question Paper

FEBRUARY – 2009
[KU 707] Sub. Code: 4182
SECOND B.PHARM. DEGREE exam
(ReRevised Regulations)Candidates Admitted upto 2003-04
Paper II – ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY
Q.P. Code : 564182
Time : 3 hours Maximum : 90 marks
I. Essay ques. : (2 X 20 = 40)
ans any 2 ques..
1. a) Briefly discuss the systematic method of nomenclature of Heterocyclic
compounds, with suitable examples. (6)
b) discuss the synthesis of quinoline and main reaction. (6)
c) provide the preparation and reactions of triphenyl methane. (8)
2. discuss the subsequent reactions:
a) Beckmann – rearrangement. (5)
b) Birch reduction. (5)
c) Meerwin-pondroff reduction. (5)
d) Asymmetric synthesis. (5)
3. a) describe Walden inversion. discuss the factor which affect its
mechanism. (10)
b) What is racemic modification? discuss the various methods that
are utilized for resolution of racemic modification. (10)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. Conventions used in stereochemistry.
2. Write the important properties of thiophen.
3. discuss the stability of cis-trans isomerism.
4. Write note on
a) Metalhydride reduction b) oxidation with selenium oxide
5. Write the structure and uses of subsequent a) Phenytoin b) Mepacrine
6. provide 3 reactions of phenothiazine.
7. Write a note on stereo chemistry of Biphenyls.
8. Medicinally important compounds of phenanthrene.
9. provide methods of preparation of anthracene.
10. Modern concept of double bond.
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. describe optical isomerism.
2. Chirality.
3. Dehydrogenation.
4. provide the structure and uses of primidone.
5. Atropisomerism.
6. Write the structure of Indole and pyrimidine.
7. elaborate triphenyl methane dyes?

Earning:   Approval pending.