Tamil Nadu Dr MGR Medical University 2009 B.Pharm III – ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY Q.PCode : 564232 - - Question Paper

FEBRUARY – 2009
[KU 741] Sub. Code: 4232
SECOND B.PHARM. DEGREE exam
(Regulation 2004)Candidates Admitted from 2004-05
Paper III – ADVANCED PHARMACEUTICAL
ORGANIC CHEMISTRY
Q.P. Code : 564232
Time : 3 hours Maximum : 90 marks
I. Essay ques. : (2 X 20 = 40)
ans any 2 ques..
1. Outline the general methods of structural elucidation chemistry and
pharmacological activity of a) Caffeine b) Reserpine c) Menthol
2. a) discuss the various kinds of elements of symmetry.
b) What is racemic modification? discuss the various methods utilized for
resolution of racemic modification.
3. a) describe Walden inversion. discuss the factors which affect its
mechanism.
b) discuss the hybridisation of orbitals.
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. provide an account on stereo chemistry of oximes.
2. Elucidate the structure of tropic acid in an atropine alkaloid.
3. Write a note on chemistry and medicinal uses of flavanoids.
4. provide the method of synthesis and explain the aromaticity and orientation in
pyridine.
5. explain the subsequent reactions with special reference to their mechanism: a)
Meerwin – pondorff reduction b) Beckmann rearrangement
6. Write a note on chemistry of cardiac glycosides.
7. describe amino acid and provide the classification of amino acids with examples.
8. Outline the preparation and explain the important chemical reaction of
a) Isoquinoline b) Imidazole.
9. explain stereoisomerism and stereomutation.
10. provide the structures of various fat soluble vitamins and mention their
deficiency diseases.
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. provide the synthesis of triphenyl methane.
2. Write the reactions of pyrrole.
3. provide short answers on circular dichroism.
4. explain the synthesis of polypeptides.
5. Classify the amino acids with examples.
6. provide the structure and uses of a) Nikethamide b) Chloro quine
7. describe essential amino acids and write any 1 method of preparation.

Earning:   Approval pending.