Tamil Nadu Dr MGR Medical University 2009 B.Pharm III – PHYSICAL PHARMACEUTICS Q.PCode : 564183 - - Question Paper

FEBRUARY – 2009
[KU 708] Sub. Code: 4183
SECOND B.PHARM. DEGREE exam
(ReRevised Regulations)Candidates Admitted upto 2003-04
Paper III – PHYSICAL PHARMACEUTICS
Q.P. Code : 564183
Time : 3 hours Maximum : 90 marks
I. Essay ques. : (2 X 20 = 40)
ans any 2 ques..
1. a) discuss the phenomenon of adsorption. elaborate the factors affecting
adsorption? (10)
b) discuss the theory behind bet adsorption isotherm. (5)
c) Classify viscometers. discuss cup and bob viscometer with neat diagram. (5)
2. a) discuss the term rheology. Differentiate newtonian and non-newtonian
fluids with example. (10)
b) discuss the hydrolysis of pharmaceutical preparations with example.
How will you prevent hydrolysis? (10)
3. a) discuss the factors causing instability of emulsion. How the stability of
emulsion is evaluated? (10)
b) elaborate the different methods of determining the binding of drugs to
proteins? discuss any 2 methods. (10)
II. Write Short Notes : (8X five = 40)
ans any 8 ques..
1. Distinguish ranging from lyophobic and lyophilic colloids.
2. discuss the formation of electrical double layer around dispersed particle.
3. Write a note on : Inclusion compounds.
4. discuss the importance of wetting and flocculation in the formulation of
suspension.
5. How will you quantify flow property of powders?
6. elaborate the applications of chemical kinetics?
7. Write a Note on : Optical properties of colloids.
8. discuss the principle involved in coulter-counter method of determining particle
size?
9. discuss critical micellar concentration and phenomenon of Micelle formation.
10. What is Fick’s legal regulations of diffusion? discuss it.
III. Short Answers: (5X2 = 10)
ans any 5 ques..
1. describe Zeta potential. How is it various from nernst potential?
2. describe surface tension. What is it due to?
3. provide 1 identification test for emulsion.
4. Differentiate ranging from half life and shelf life.
5. Write 2 applications of complexation.
6. What is meant by plug flow? What is it due to?
7. describe Angle of repose.

Earning:   Approval pending.