Tamil Nadu Dr MGR Medical University 2009 B.Pharm II – CHEMISTRY OF SYNTHETIC DRUGS Q.PCode : 564208 - - Question Paper

FEBRUARY – 2009
[KU 720] Sub. Code: 4208
THIRD B.PHARM. DEGREE exam
(Re-Revised Regulations)Candidates Admitted upto 2003-04
Paper II – CHEMISTRY OF SYNTHETIC DRUGS
Q.P. Code : 564208
Time : 3 hours Maximum : 90 marks
I. Essay ques. : ans any 2 ques.. (2 X 20 = 40)
1. a) describe local anaelthics and provide their classification. (4)
b) discuss in detail about any 4 local anaesthtic drugs. (16)
2. a) describe cancer and provide the pharmacological classification of drugs used
as anti cancer agents. (5)
b) discuss in detail about the subsequent.
i) Cyclophosphamide
ii) Chlorambucil.
iii) 5-Fluro uracil. (15)
3. a) SAR of barbiturates . (5)
b) discuss in detail about the subsequent
i) Phenobarbitone. (5)
ii) Mepho barbitone. (5)
iii) Buto barbitone. (5)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. provide the synthesis and assay of phenytoin.
2. provide the synthesis of Diazepam.
3. provide any five structures of anti tubercular drugs.
4. Hydrogen bonding explain:
5. Partition coefficient.
6. provide the structure, use and assay of levodopa.
7. describe analgesics and provide the pharmacological classification of narcotic
analgesics.
8. provide the structure of indomethacin and Ibuprofen.
9. describe anti depressants and provide the synthesis of imipramine.
10. provide the synthesis and uses of nikethamide.
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. Synthesis of valproic acid.
2. Structure of chlorpromazine and haloperidol.
3. Structure of aspirin and paracetamol.
4. Synthesis of aspirin.
5. Synthesis of cyclopropane.
6. describe general anaesthestics and provide any 2 structures.
7. Structure of nicotinic acid and chlorpheniramine maleate.
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Earning:   Approval pending.