Tamil Nadu Dr MGR Medical University 2009 B.Pharm II – MEDICINAL CHEMISTRY - I Q.PCode : 564237 - - Question Paper

FEBRUARY – 2009
[KU 746] Sub. Code: 4237
THIRD B.PHARM. DEGREE exam
(Regulation 2004)Candidates Admitted from 2004-05
Paper II – MEDICINAL CHEMISTRY - I
Q.P. Code : 564237
Time : 3 hours Maximum : 90 marks
I. Essay ques. : (2 X 20 = 40)
ans any 2 ques..
1. a) elaborate drug-receptor interaction? discuss various kinds of binding
forces exist in drug-receptor interaction with example. (10)
b) discuss the basic concept of prodrug with example. provide it application (10)
2. a) describe the terms sedative and hypnotic. Classify them with every one
example with chemical structure for every class. (7)
b) Brief the SAR of barbiturates. (6)
c) provide the synthesis and use of diazepam and barbital. (4+3=7)
3. a) Classify diuretics on the basis of site of action with 1 example. (5)
b) elaborate loop diuretics? discuss its mode of action. (5)
c) Brief the SAR of thiazide diuretics. (5)
d) Outline the synthesis of Acetazolamide and furosemide. (5)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. How does hydrogen bonding affect biological activity? discuss with
example.
2. Write a brief note on phase –II biotransformation pathway.
3. Classify general anaesthetics with example, outline the synthesis of
ketamine.
4. define the synthesis and clinical use of
i) Amitriptylene, ii)Imipramine
5. explain in detail the adrenergic blocking agents. Outline the synthesis of
metoprolol.
6. Write the chemical classification of local anaesthetics giving example.
define their mode of action.
7. Brief the SAR of H1 – receptor antagonist. provide the synthesis of any one
drug.
8. Classify non- steroidal anti-inflammatory agents on the basis of chemistry
with 1 every example. discuss its mode of action.
9. Write the structure and clinical use of
i) Morphine, ii) Phenytoin, iii) aspirin, iv) phenobarbitone, v) Benzocaine
10. discuss what is ISO- sterism?
III. Short Answers: ans any 5 ques.. (5X2 = 10)
1. Enumerate the physiochemical properties in relation to biological action.
2. describe drug metabolism. Mention the kinds of biotransformation pathways.
3. elaborate Hydantoins? Write the chemistry of Hydantoins.
4. Enumerate the biosynthesis of noradrenaline.
5. Write the name and structure of H1 – receptor antagonist possessing
pyridine and piperidine moieties.
6. elaborate anti-tussive agents? provide the structure and use of Benzotartate.
7. elaborate prostaglandins? Mention the biosynthetic pathways for ecosanoids.

Earning:   Approval pending.