Tamil Nadu Dr MGR Medical University 2009 B.Pharm V – MODERN METHODS OF PHARMACEUTICAL ANALYSIS Q.PCode : 564246 - - Question Paper

FEBRUARY – 2009
[KU 755) Sub. Code: 4246
FOURTH B.PHARM. DEGREE exam
(Regulations 2004)Candidates Admitted from 2004-05
Paper V – MODERN METHODS OF PHARMACEUTICAL ANALYSIS
Q.P. Code : 564246
Time : 3 hours Maximum : 90 marks
I. Essay ques. : ans any 2 ques.. (2 X 20 = 40)
1. Write the principles involved in different conductometric titration. discuss
different curves of them. (20)
2. a) What is thin layer chromatography. discuss in detail on the stationary
phase, mobile phase, techniques and applications of TLC.(15)
b) Write the significance of reverse phase chromatography. (5)
3. a) discuss sample preparation techniques in IR spectrophotometry. (5)
b) Write the principle and applications of counter current extraction
and gel filtration. (5)
c) Classify ion exchangers applied in chromatography with suitable
examples. (5)
d) Brief 2 laws governing absorption of radiation and mention their
limitations. (5)
II. Write Short Notes : ans any 8 ques.. (8X five = 40)
1. define the factors affecting intensity of fluorescence.
2. Mention the defectors used in ultraviolet visible spectrophotometers. discuss
any 1 of them.
3. discuss the principle, Instrumentation and working of Gas chromatography.
4. describe and brief the subsequent.
a) Residual current b) Half wave potential
5. Write a note on Radio immunoassay.
6. provide details on the a) International organization for standardization.
b) International conference on harmonization.
7. Enumerate the differences ranging from a) Paper chromatography and TLC
b) GLC and HPLC
8. Write the working principle and any 2 applications of the subsequent
a) Nuclear magnetic Resonance. b) Electron spin Resonance.
9. Advantages of potentiometric titrations.
10. Preparation techniques for preparing columns in column chromatography
III. Short Answers:Answer any 5 ques.. (5X2 = 10)
1. What is iso bestic point and bathochromic shift?
2. describe precision and errors.
3. describe basepeak and provide 1 of its importance.
4. What do you mean by retention time and retention volume?
5. List out the kinds of quenching.
6. What is color cycle?
7. Write the significance of finger print region.

Earning:   Approval pending.