Tamil Nadu Dr MGR Medical University 2009 B.Pharm MPharm Branch I -Pharmaceutics - III – BIOPHARMACEUTICS AND PHARMACOKINETICS - Question Paper

MARCH -2009
[KU 317] Sub. Code: 2853
M.PHARM. DEGREE exam
(Regulations 2006)
Candidates admitted from 2006-2007 onwards
FIRST YEAR
Branch I – PHARMACEUTICS
Paper III – BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code : 262853
Time : 3 hours Maximum : 100 marks
ans All ques.
I. Essay ques. : (3 X 20 = 60)
1. a) discuss the significance of Bioavailability studies. Enumerate the criterias
for establishing bioequivalence requirement.
b) explain the importance of invitro,invivo correlation in the bioavailability
studies.
2. a) explain and compare the different approaches available for the
pharmacokinetic analysis of the experimental data subsequent intravenous
bolus administration in 1 compartment open model.
b) elaborate the causes of non linearity. How will you detect non-linearity.
discuss Michaelis menton formula.
3. a) explain the mechanism of drug absorption.
b) discuss in detail the physiological and physico chemical factors effecting
gastro intestinal drug absorption.
II. Write Short Notes : (8 X five = 40)
1. 2 compartment model
2. quantity of distribution
3. explain the diffusion layer theory.
4. Area and 1st movement curve
5. Renal clearance
6. Concept of loading dose and maintenance dose.
7. Enhancement of bio availability of drugs.
8. Pharmacokinetic variability factors.

Earning:   Approval pending.