Thapar University 2006 M.Sc Bio Chemistry Biostatics & Bioinformatics - Question Paper
Thapar Institute of Engineering & Technology
M.Sc. Biotechnology (1st Year)
Final Term exam
BH004 (Biostatics & Bioinformatics)
THAPAR INSTITUTE OF ENGINEERING & TECHNOLOGY, PATIALA (Department of Biotechnology & Environmental Sciences)
M.Sc I year Biotechnology (End semester Examination)
BH004: Biostatistics & Bioinformatics
Time: 3 hours Max. Marks: 36
Answer any six questions
1. What are the basic principles to be observed in experimental design? Explain briefly the various types of experimental designs. (6.0)
2. By using UPGMA, reconstruct a phylogenetic tree using the following distance matrix. (6.0)
|
Species |
A |
B |
C |
D |
|
B |
3 |
- |
- |
- |
|
C |
6 |
5 |
- |
- |
|
D |
9 |
9 |
10 |
- |
|
E |
12 |
11 |
13 |
9 |
3. What is Needleman and Wunsch algorithm? By using maximum-match pathway draw a complete matrix for the sequences YFLQLK.FDPELLFGVQ and YHFKLKFDPELLFNQQ. (6.0)
4. Write short notes of the following : (2x3= 6.0)
a) BLOSUMandPAM
b) Dot Plot
c) Maximum Parsimony
5. Write short notes of the following: (2 x 3= 6.0)
a) PSI- BLAST
b) Hidden Markov Model
c) BLOCKS
6. Describe multiple sequence alignment giving emphasis on ClustalW and MultAlin. (6.0)
7. An experiment was carried out to test the effect of 4 different training methods on increasing mental ability of children. Each training method was given to one group of 5 children. The four groups of children were matchcd for age and sex. Test whether the four methods of training differ significantly with each other using ANOVA. (6.0)
|
Mental ability by methods of training | |||
|
A |
B |
C |
0 |
|
15 |
12 |
10 |
14 |
|
20 |
17 |
15 |
20 |
|
16 |
11 |
12 |
16 |
|
19 |
IB |
14 |
18 |
|
19 |
16 |
14 |
13 |
8. Write short notes of the following: (1.5\4= 6.0)
a) Correlation
b) Standard Deviation
c) Probability laws
d) Dunncts test
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Attachment: |
| Earning: Approval pending. |
