Saurastra University 2006 M.Sc Computer Science Analytical Chemistry : - X (Selected Topics in Analytical Chemistry) - Question Paper

M. Sc. (Part - II) exam
April / May – 2006
Analytical Chemistry : Paper - X
(Selected Topics in Analytical Chemistry)
Time : three Hours] [Total Marks : 100
Instructions : (1) All ques. carry equal marks.
(2) Attempt 5 ques. in all.
(3) ques. one is compulsory.
(4) Attempt any 4 from Q. No two to 7.
1 ans the subsequent : (any five)
(a) How will you distinguish cis and trans isomers by x-ray
technique?
(b) describe half-life period, avg. life and radio active decay
constant. How they are interrelated?
(c) describe the terms : QC, QA, GLP and GMP.
(d) discuss 4 kinds of validation in brief.
(e) elaborate
(i) Certified reference material
(ii) Pharmacopaeal standard and
(iii) Working standard.
(f) describe the subsequent :
(i) Diffusion current
(ii) Residual current
(iii) Migration current
(iv) Limiting current.
(g) How will you analyse lead in solder wire?
(h) What is ion selective electrode? Classify and discuss the
selectivity of it.
2 ans the subsequent :
(a) discuss the terms : specificity, accuracy, precision, detection
limit, robustness with relevant reference to analytical method
validation.
(b) Write a note on ICH guidelines and their scopes of work.
3 ans the subsequent : (any three)
(a) describe SOP. What is standard format of SOP of SOP?
(b) elaborate intellectual property rights? describe patents and
requirement of patent filing.
(c) explain GLP principles and their role.
(d) Write a note on : importance of chirality or polymorphism
in pharmaceutical industry.
4 ans the subsequent : (any three)
(a) What is polarography? Derive an formula for half wave
potential and discuss the terms involve it.
(b) discuss the subsequent :
(i) Ilkovic formula
(ii) Polarographic maxima
(iii) DME.
(c) define the calibration curve method and pilot ion method
for the valuation of polarogram.
(d) In particular polarographic analysis of copper,
C = one × 10-4 M, id1 = 17.5  a and for unknown solution of
copper if id2 = 27.9  a, what would be its concentration (C2)?
5 ans the subsequent : (any three)
(a) What is bio-catalytic membrane electrode? How will you
determine blood urea nitrogen by this electrode?
(b) Write a note on liquid membrane electrode.
(c) define gas sensing electrode for CO
2
gas selective probe
system.
(d) discuss crystalline membrane electrode. Briefly explain
fluoride ion electrode.
6 ans the subsequent : (any three)
(a) Write a note on isotopic dilution method.
(b) define radiometric titration in detail. How they perform ?
(c) provide an account of various methods of radio activity
measurement. What is standard deviation? How it is
calculated?
(d) Write note on neutron activation analysis.
ST-2743] two [Contd..
7 ans the subsequent :
(a) How X-rays are generated? discuss the emission of K and
L line X-rays.
(b) define the X-ray spectrometer. provide an account of
applications of diffraction method.
(c) What is X-ray diffraction? explain any 2 X-ray diffraction
method.
______________
ST-2743] three [ 100 ]

Earning:   Approval pending.