Saurastra University 2006 B.Pharm Pharmaceutical Dosage Form Design - Question Paper

Fourth Year B. Pharm. exam
March / April – 2006
Pharmaceutical Dosage Form Design
Time : three Hours] [Total Marks : 80
Instructions : Attempt 4 ques. from every part.
part - I
1 (a) describe pre formulation. provide its objectives. explain 4
the pre formulation method.
(b) explain the importance of the subsequent in 6
formulation development :
(i) Particle size characterization
(ii) Salts and prodrugs.
2 (a) explain the effects of presence of organoleptic agents 5
in a formulation.
(b) provide the factors affecting flow properties of a powder. 5
How flow of a powder can be improved ?
3 (a) explain in detail basic guide lines for selection 5
of a preservative.
(b) provide the kinds of antioxidants. discuss their mode 5
of action.
4 (a) explain the different kinds of modifications that take place 5
during storage in liquid and semisolid formulations.
(b) define hydrolytic decomposition of drugs with 5
suitable examples, how such decomposition can be
minimized ?
5 (a) describe “stability of pharmaceutical products.” explain 5
briefly the factors affecting the stability of pharmaceutical
products.
(b) describe half life and self life. explain a method of 5
determining half life and self life pharmaceutical dosage
form.
SA-7667] two [ 100 ]
part - II
6 (a) explain the methods of stabilization of the disperse 5
system.
(b) Write detail note on physical stability of tablets. 5
7 (a) Comment on the subsequent statements with cause : 10
(i) Molecular modification in drug molecule during pre
formulation process is aimed to improve bioavailability.
(ii) Conversion of an anhydrous compound to hydrate
form within the dosage form may affect the extent
of drug absorption.
(iii) It is compulsory to suggest the expiry date on every
pharmaceutical product.
(iv) Drugs having precise dose titration and narrow
therapeutic index have critical performance when
incorporated into sustained release formulation.
(v) Amorphous form of a drug have higher dissolution
rate.
8 (a) Which kinds of drugs are not suitable for oral 5
sustained release form? provide examples.
(b) provide the advantages and disadvantages of sustained 5
release dosage form.
9 (a) Write a detail note on design and formulation of 5
multiple layer tablets and tablet based on osmotic
system.
(b) explain briefly methods of valuation of sustained 5
release dosage form.
10 (a) Enumerate different novel drug delivery system 5
recently reported. explain basic designing concepts
“occusert”.
(b) explain the role of aerosol and inhalation formulation 5
as a novel drug delivery system.
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Earning:   Approval pending.