Punjab Technical University 2010 B.Pharm Second Semester (ember-) Pharmaceutical Chemistry-III - Question Paper

B. Pharm (PTU)
Second Semester exam (December-2010)
Pharmaceutical Chemistry-III

Time: three Hours Max. Marks: 80

Note: 1) part A is compulsory.
2) Attempt any 4 ques. from part B.
3) Attempt any 3 ques. from part C.

Section-A
(15×2=30)
Ques 1a) elaborate Lewis acids, provide 1 example.
Ques 1b) Which is stronger acid of subsequent pair and why? Hydronium ion or water.
Ques 1c) What is optical purity?
Ques 1d) provide 2 applications of Grignard reagent.
Ques 1e) Draw and specify R&S configuration of 3-bromohexane.
Ques 1f) What do you understand by racemic modification?
Ques 1g) What is dipole moment provide example?
Ques 1h) elaborate atomic orbital.
Ques 1i) describe bond dissociation energy.
Ques 1j) describe melting point
Ques 1k) describe term conformation.
Ques 1l) elaborate nuclephiles. provide 2 examples.
Ques 1m) describe diastereomers with 1 example.
Ques 1n) elaborate homolytic and heterolytic reaction.
Ques 1o) describe Metamerism.

Section-B
(4×5=20)
Ques 2) discuss the Huckel 4n + two rule with examples and draw its significance.

Ques 3) provide mechanism of reaction of various kinds of organometallic compounds with alkyl halides.

Ques 4) explain mechanism of hydroboration oxidation.

Ques 5) explain effect of solvent on SN2 versus SN1 reaction giving example.

Ques 6) Differentiate ranging from stereoselective and stereospecific reaction with example.

Section-C
(3×10=30)
Ques 7) discuss why benzene undergo electrophillic substitution whereas alkene undergoes addition reaction.

Ques 8) Write note on the following:
a) Chlorofluorocarbons and their threat to life on earth.
b) Phase transfer catalysis.

Ques 9) describe the terms – carbocation, carbonium and carbenium ion. elaborate various kind of reactions of carbocations learned by you so far. provide suitable example.

Ques 10) How do you account for the observations that aldehydes and ketones undergoes nucleophillic addition to carbonyl group whereas acyl derivatives undergoes nucleophillic substitution.

Earning:   Approval pending.